The development of new non-invasive therapeutic strategy of dyschromatosis symmetrica hereditaria with topical agent

• Project/Area Number: 24591646
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Nagoya University
• Principal Investigator: Kono Michihiro 名古屋大学, 医学(系)研究科(研究院), 講師 (60319324)
• Co-Investigator(Kenkyū-buntansha): AKIYAMA Masashi 名古屋大学, 大学院医学系研究科, 教授 (60222551)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 遺伝性対側性色素異常症 / dyschromatosis / DSH / RNA編集 / 治療 / 遺伝子診断

Outline of Final Research Achievements

Dyschromatosis symmetrica hereditaria (DSH) is a hereditary pigmentary disorder caused by heterozygous mutations in ADAR1 encoding an RNA editing enzyme. The elucidation of pathogenesis and establishment of definitive therapy of DSH have still remained.
This study aimed for development of a novel topical treatment for DSH. At first, we planed identification of candidate compounds which upregulate the RNA editing activity by the drug library screening and, in addition, planed establishment of DSH model mice for evaluation of efficacy of the candidate drugs.
We could not identify a novel agent to up-regulate RNA editing activity within the present study period. Furthermore, we tried to develop a gene modification mouse, but the mouse mimicking the clinical manifestations of the human DSH was not established. Within the present study period, we also performed the genetic diagnosis of several DSH patients and contributed to their final diagnoses.

Research Products

• [Journal Article] Angiofibroma of soft tissue in the cheek: diagnosis confirmed by gene rearrangement in NCOA2. (2016)
  • Author(s): Jeong JW, Kono M, Hasegawa-Murakami Y, Motoi T, Yokota K, Matsumoto T, Kaibuchi-Ando K, Kato Y, Tada T, Akiyama M.
  • Journal Title: Acta Derm Venereol. Volume: -
  • Peer Reviewed / Open Access
• [Journal Article] A case of epidermolytic ichthyosis showing a very mild phenotype due to a novel tail extension mutation in KRT10. (2016)
  • Author(s): Kono M, Fukai K, Omura R, Sugawara K, Tsuruta D, K Sugiura K, Akiyama M.
  • Journal Title: J Eur Acad Dermatol Venereol. Volume: -
  • Peer Reviewed
• [Journal Article] A 45-year-old woman with Ehlers-Danlos syndrome caused by dermatan 4-O-sulfotransferase-1 deficiency: implications of dermatan sulfate depletion on early aging. (2016)
  • Author(s): Kono M, Hasegawa-Murakami Y, Sugiura K, Ono M, Toriyama K, Miyake N, Hatamochi A, Kamei Y, Kosho T, Akiyama M.
  • Journal Title: Acta Derm Venereol. Volume: - Pages: 1-2
  • DOI: 10.2340/00015555-2390
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IgE-independent pathophysiology of severe atopic dermatitis demonstrated in an IgE-deficient patient. (2016)
  • Author(s): Ogawa Y, Kono M, Tsujikawa M, Tsujiuchi H, Akiyama M.
  • Journal Title: J Dermatol Sci. Volume: - Issue: 2 Pages: 139-141
  • DOI: 10.1016/j.jdermsci.2016.01.008
  • Peer Reviewed
• [Journal Article] Hyperpigmentation over the metacarpophalangeal joints and the malleoli in a case of hyaline fibromatosis syndrome with ANTXR2 mutations. (2016)
  • Author(s): Sugiura K, Ohno A, Kono M, Kitoh H, Itomi K, Akiyama M.
  • Journal Title: J Eur Acad Dermatol Venereol. Volume: - Issue: 10 Pages: 44-46
  • DOI: 10.1111/jdv.13290
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Reticulate acropigmentation of Kitamura with a novel ADAM10 mutation: a case report. (2016)
  • Author(s): Tsutsumi M, Kono M, Akiyama M, Katoh N, Nakai N.
  • Journal Title: J Dermatol Volume: - Issue: 8 Pages: 1-2
  • DOI: 10.1111/1346-8138.13308
  • Peer Reviewed / Open Access
• [Journal Article] Hyper-IgE syndrome with a novel mutation of the STAT3 gene. (2016)
  • Author(s): Minakawa S, Tanaka H, Kaneko T, Matsuzaki Y, Kono M, Akiyama M, Minegishi Y, Sawamura D.
  • Journal Title: Clin Exp Dermatol. Volume: -
  • Peer Reviewed
• [Journal Article] Dyschromatosis symmetrica hereditaria and Aicardi-Goutires syndrome 6 are phenotypic variants caused by ADAR1 mutations. (2016)
  • Author(s): Kono M, Matsumoto F, Suzuki Y, Suganuma M, Saitsu H, Ito Y, Fujiwara S, Matsumoto K, Moriwaki S, Matsumoto N, Tomita Y, Sugiura K, Akiyama M.
  • Journal Title: J Invest Dermatol. Volume: 136 Issue: 4 Pages: 875-8
  • DOI: 10.1016/j.jid.2015.12.034
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Unilateral generalized linear porokeratosis with nail dystrophy. (2016)
  • Author(s): Kono M, Yokoyama N, Ogawa Y, Takama H, Sugiura K, Akiyama M.
  • Journal Title: J Dermatol Volume: 43 Issue: 3 Pages: 286-7
  • DOI: 10.1111/1346-8138.13204
  • Peer Reviewed
• [Journal Article] Genetic analyses of oculocutaneous albinism types 2 and 4 with eight novel mutations. (2016)
  • Author(s): Okamura K, Araki Y, Abe Y, Shigyou A, Fujiyama T, Baba A, Kanekura T, Chinen Y, Kono M, Niizeki H, Tsubota A, Konno T, Hozumi Y, Suzuki T.
  • Journal Title: J Dermatol Sci. Volume: 81 Issue: 2 Pages: 140-2
  • DOI: 10.1016/j.jdermsci.2015.10.014
  • Peer Reviewed
• [Journal Article] Porokeratotic eccrine ostial and dermal duct nevus with a somatic homozygous or monoallelic variant of connexin 26. (2015)
  • Author(s): Noda K, Sugiura K, Kono M, Akiyama M.
  • Journal Title: J Dermatol Sci Volume: 80 Issue: 1 Pages: 74-6
  • DOI: 10.1016/j.jdermsci.2015.07.003
  • Peer Reviewed
• [Journal Article] Impetigo herpetiformis with IL36RN mutations in a Chinese patient: A founder haplotype of c.115+6T>C in East Asia. (2015)
  • Author(s): Sugiura K, Nakasuka A, Kono H, Kono M, Akiyama M.
  • Journal Title: J Dermatol Sci Volume: 79 Issue: 3 Pages: 319-20
  • DOI: 10.1016/j.jdermsci.2015.06.003
  • Peer Reviewed
• [Journal Article] Buruli ulcer successfully treated with negative-pressure wound therapy. (2015)
  • Author(s): Murase C, Kono M, Nakanaga K, Ishii N, Akiyama M.
  • Journal Title: JAMA Dermatol. Volume: 151 Issue: 10 Pages: 1137-9
  • DOI: 10.1001/jamadermatol.2015.1567
  • Peer Reviewed
• [Journal Article] Dowling-Degos disease with mutations in POFUT1 is clinicopathologically distinct from reticulate acropigmentation of Kitamura. (2015)
  • Author(s): Kono M, Suganuma M, Takama H, Zarzoso I, Saritha M, Bodet D, Aboobacker S, Kaliaperumal K, Suzuki T, Tomita Y, Sugiura K, Akiyama M.
  • Journal Title: Br J Dermatol Volume: 173 Issue: 2 Pages: 584-6
  • DOI: 10.1111/bjd.13702
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Annular Elastolytic Giant Cell Granuloma Successfully Treated with Minocycline Hydrochloride. (2015)
  • Author(s): Nanbu A, Sugiura K, Kono M, Muro Y, Akiyama M.
  • Journal Title: Acta Derm Venereol. Volume: in press Issue: 6 Pages: 756-7
  • DOI: 10.2340/00015555-2056
  • Peer Reviewed / Open Access
• [Journal Article] Lymphatic flow is mostly preserved after sentinel lymph node biopsy in primary cutaneous malignant melanoma. (2015)
  • Author(s): Yokota K, Sawada M, Matsumoto T, Hasegawa Y, Kono M, Akiyama M.
  • Journal Title: J Dermatol Sci. Volume: 78 Issue: 2 Pages: 101-7
  • DOI: 10.1016/j.jdermsci.2015.02.011
  • Peer Reviewed
• [Journal Article] アトピー性皮膚炎とフィラグリン遺伝子 (2015)
  • Author(s): 河野 通浩, 秋山 真志
  • Journal Title: チャイルドヘルス Volume: 18 Pages: 660-2
• [Journal Article] 色素失調症の男児例 (2015)
  • Author(s): 清水奈美, 深井和吉, 小澤俊幸, 新宅治夫, 河野通浩, 鶴田大輔
  • Journal Title: 日本小児皮膚科学会雑誌 Volume: 34 Pages: 113-6
  • Peer Reviewed
• [Journal Article] Large epidermal cleft formation in verrucous-keratotic malignant melanoma on the heel (2015)
  • Author(s): Takaaki Matsumoto, Kenji Yokota, Masaki Sawada, Yoshie Hasegawa, Aya Takeuchi, Michihiro Kono, Masashi Akiyama
  • Journal Title: J Am Acad Dermatol. Volume: 72 Issue: 1 Pages: e37-e38
  • DOI: 10.1016/j.jaad.2014.09.044
  • Peer Reviewed
• [Journal Article] Revertant Mutation Releases Confined Lethal Mutation, Opening Pandora' s Box : A Novel Genetic Pathogenesis (2014)
  • Author(s): Ogawa Y, Takeichi T, Kono M, Hamajima N, Yamamoto T, Sugiura K, Akiyama M
  • Journal Title: PLoS Genet Volume: 10(5) Issue: 5 Pages: e1004276-e1004276
  • DOI: 10.1371/journal.pgen.1004276
  • Peer Reviewed / Open Access
• [Journal Article] Urticaria pigmentosa complicated with esophageal eosinophilia (2014)
  • Author(s): Rirei Nin-Asai, Michihiro Kono, Masashi Akiyama
  • Journal Title: J Am Acad Dermatol. Volume: 71 Issue: 5 Pages: e207-e208
  • DOI: 10.1016/j.jaad.2014.05.037
  • Peer Reviewed
• [Journal Article] Proposed classification of longitudinal melanonychia based on clinical and dermoscopic criteria. (2014)
  • Author(s): Sawada M, Yokota K, Matsumoto T, Shibata S, Yasue S, Sakakibara A, Kono M, Akiyama M
  • Journal Title: Int J Dermatol. Volume: 53 Pages: 581-5
  • Peer Reviewed
• [Journal Article] Comprehensive screening for a complete set of Japanese-population-specific filaggrin gene mutations (2014)
  • Author(s): Kono M, Nomura T, Ohguchi Y, Mizuno O, Suzuki S, Tsujiuchi H, Hamajima N, McLean WH, Shimizu H, Akiyama M.
  • Journal Title: Allergy Volume: 69(4) Issue: 4 Pages: 537-540
  • DOI: 10.1111/all.12369
  • Peer Reviewed / Open Access
• [Journal Article] Spindle cell carcinoma of the breast in a patient with neurofibromatosis type 1. (2014)
  • Author(s): Nogimori M, Yokota K, Sawada M, Matsumoto T, Kono M, Akiyama M.
  • Journal Title: Eur J Dermatol. Volume: 24 Issue: 3 Pages: 397-8
  • DOI: 10.1684/ejd.2014.2329
  • Peer Reviewed
• [Journal Article] 頭頂部のVascular Eccrine Spiradenomaの1例 (2014)
  • Author(s): 安達明子, 横田憲二, 河野 通浩, 澤田昌樹, 松本高明, 長谷川佳恵, 山中直樹, 室 慶直, 秋山 真志
  • Journal Title: 皮膚科の臨床 Volume: 56 Pages: 835-7
  • Peer Reviewed
• [Journal Article] Highly prevalent LIPH founder mutations causing autosomal recessive woolly hair/hypotrichosis in Japan and the genotype/phenotype correlations (2014)
  • Author(s): Tanahashi K, Sugiura K, Kono M, Takama H, Hamajima N, Akiyama M
  • Journal Title: PLoS ONE Volume: 9(2) Issue: 2 Pages: e89261-e89261
  • DOI: 10.1371/journal.pone.0089261
  • Peer Reviewed
• [Journal Article] Spindle cell angiosarcoma almost exclusively made up of spindle cells. (2014)
  • Author(s): Makita S, Kono M, Yamada M, Suzuki N, Karasawa T, Tanahashi C, Akiyama M.
  • Journal Title: Eur J Dermatol Volume: 24 Issue: 1 Pages: 106-7
  • DOI: 10.1684/ejd.2013.2224
  • Peer Reviewed
• [Journal Article] 【網状を呈する皮膚疾患】topics 網状肢端色素沈着症 原因遺伝子の解明. (2014)
  • Author(s): 河野通浩
  • Journal Title: 皮膚病診療 Volume: 36 Pages: 206-12
• [Journal Article] Novel ADAR1 mutations including single amino acid deletion in the deaminase domain underly dyschromatosis symmetrica hereditaria in Japanese families (2013)
  • Author(s): Kono M, Suganuma M, Ito Y, Ujiie H, Morimoto K, Akiyama M
  • Journal Title: Int J Dermatol Volume: 印刷中 Issue: 3
  • DOI: 10.1111/j.1365-4632.2012.05765.x
  • Peer Reviewed
• [Journal Article] Extraordinarily large, giant spider angioma in an alcoholic cirrhotic patient. (2013)
  • Author(s): Hane H, Yokota K, Kono M, Muro Y, Akiyama M.
  • Journal Title: Int J Dermatol Volume: 53 Issue: 2
  • DOI: 10.1111/j.1365-4632.2012.05548.x
  • Peer Reviewed
• [Journal Article] Dyschromatosis symmetrica hereditaria by ADAR1 mutations and viral encephalitis: a hidden link? (2013)
  • Author(s): Kono M, Akiyama M, Suganuma M, Sanchez-Valle A, Tomita Y.
  • Journal Title: Int J Dermatol Volume: 52 Issue: 12 Pages: 1582-4
  • DOI: 10.1111/j.1365-4632.2011.05372.x
  • Peer Reviewed
• [Journal Article] Clinico-pathologic Analysis of 66 Japanese Thin Melanomas with Metastasis of Sentinel or Regional Lymph Node. (2013)
  • Author(s): Mori M, Sugiura M, Kono M, Matsumoto T, Sawada M, Yokota K, Yasue S, Shibata S, Sakakibara A, Nakamura S, Tomita Y, Akiyama M.
  • Journal Title: J Cutan Pathol Volume: 40 Issue: 12 Pages: 1027-34
  • DOI: 10.1111/cup.12222
  • Peer Reviewed
• [Journal Article] The majority of generalized pusular psoriasis without psoriasis vulgaris is caused by deficiency of interleukin-36 receptor antagonist. (2013)
  • Author(s): Sugiura K, Takemoto A, Yamaguchi M, Takahashi H, Shoda Y, Mitsuma T, Tsuda K, Nishida E, Togawa Y, Nakajima K, Sakakibara A, Kawachi S, Shimizu M, Ito Y, Takeichi T, Kono M, Ogawa Y, Muro Y, Ishida-Yamamoto A, Sano S, Matsue H, Morita A, Mizutani H, Iizuka H, Muto M, Akiyama M.
  • Journal Title: J Invest Dermatol Volume: 133 Issue: 11 Pages: 2514-2521
  • DOI: 10.1038/jid.2013.230
  • Peer Reviewed
• [Journal Article] Whole-exome sequencing identifies ADAM10 mutations as a cause of reticulate acropigmentation of Kitamura, a clinical entity distinct from Dowling-Degos disease. (2013)
  • Author(s): Kono M, Sugiura K, Suganuma M, Hayashi M, Takama H, Suzuki T, Matsunaga K, Tomita Y, Akiyama M.
  • Journal Title: Hum Mol Genet Volume: 22 Issue: 17 Pages: 3524-3533
  • DOI: 10.1093/hmg/ddt207
  • Peer Reviewed
• [Journal Article] Sporadic VACTERL association in a Japanese family with Sjogren-Larsson syndrome. (2013)
  • Author(s): Takeichi T, Sugiura K, Arai H, Ishii K, Kono M, Akiyama M.
  • Journal Title: Acta Dermato-Venereol Volume: 93 Issue: 5 Pages: 579-580
  • DOI: 10.2340/00015555-1526
  • Peer Reviewed
• [Journal Article] 皮膚病理へのいざない(第1回) 総論および皮膚腫瘍(Part I) 表皮系良性腫瘍(疣贅を含む)と有棘細胞癌(前駆症を含む)(解説) (2013)
  • Author(s): 河野通浩
  • Journal Title: 日本皮膚科学会雑誌 Volume: 123 Pages: 2621-2624
• [Journal Article] Novel ABCA12 splice site deletion mutation and ABCA12 mRNA analysis of pulled hair samples in harlequin ichthyosis (2013)
  • Author(s): Takeichi T, Sugiura K, et al.
  • Journal Title: J Dermatol Sci Volume: 69 Issue: 3 Pages: 259-261
  • DOI: 10.1016/j.jdermsci.2012.11.004
  • Peer Reviewed
• [Journal Article] Severe chilblain lupus is associated with heterozygous missense mutations of catalytic amino acids or their adjacent in the exonuclease domains of 3'-repair exonuclease 1 (2012)
  • Author(s): Sugiura K
  • Journal Title: J Invest Dermatol Volume: 132 Issue: 12 Pages: 2855-2857
  • DOI: 10.1038/jid.2012.210
  • Peer Reviewed
• [Journal Article] Dyschromatosis symmetrica hereditaria with long hair on the forearms, hypo/hyperpigmented hair, and dental anomalies: report of a novel ADAR1 mutation. (2012)
  • Author(s): Kantaputra PN, Chinadet W, Ohazama A, Kono M.
  • Journal Title: Am J Med Genet A. Volume: 158A Issue: 9 Pages: 2258-65
  • DOI: 10.1002/ajmg.a.35488
  • Peer Reviewed
• [Journal Article] Oculocutaneous albinism 1 minimal pigment type : a case report on the analysis of genotype of an OCA1MP patient (2012)
  • Author(s): Kono, M., Kondo, T., Ito, S., Suzuki, T., Wakamatsu, K, et al
  • Journal Title: Br.J.Dermatol. Volume: 166 Issue: 4 Pages: 896-898
  • DOI: 10.1111/j.1365-2133.2011.10690.x
  • Peer Reviewed
• [Journal Article] Four novel ADAR1 gene mutations in patients with dyschromatosis symmetrica hereditaria (2012)
  • Author(s): Kono M, Akiyama M, Kondo T, Suzuki T, Suganuma M, Wataya-Kaneda M, Lam J, Shibaki A, Tomita Y
  • Journal Title: J Dermatol Volume: 39 Issue: 9 Pages: 819-21
  • DOI: 10.1111/j.1346-8138.2011.01385.x
  • Peer Reviewed
• [Journal Article] A novel IL36RN/IL1F5 homozygous nonsense mutation, p.Arg10X, in a Japanese patient with adult-onset generalized pustular psoriasis (2012)
  • Author(s): Sugiura K
  • Journal Title: Br J Dermatol Volume: 167 Issue: 3 Pages: 699-701
  • DOI: 10.1111/j.1365-2133.2012.10953.x
  • Peer Reviewed
• [Presentation] アトピー性皮膚炎（ＡＤ）と好酸球性胃腸炎患者におけるフィラグリン（FLG）遺伝子変異の検討. (2016)
  • Author(s): 皆川智子、金子高英、松﨑康司、中野 創、澤村大輔、平賀寛人、櫻庭裕丈、河野通浩、秋山真志.
  • Organizer: 第79回日本皮膚科学会東京・東部支部合同学術大会
  • Place of Presentation: 東京都新宿区（京王プラザホテル）
  • Year and Date: 2016-02-20
• [Presentation] 第15回浜名湖皮膚病理研究会「左頬部皮下結節の一例」の経過と最終診断. (2016)
  • Author(s): Jeong Jin-Wook、長谷川佳恵、河野通浩、秋山真志、加藤陽一.
  • Organizer: 第16回浜名湖皮膚病理研究会
  • Place of Presentation: 静岡県浜松市（TPK 浜松アクトタワー カンファレンスセンター）
  • Year and Date: 2016-02-13
• [Presentation] 遺伝性対側性色素異常症と Aicardi-Goutieres症候群6はADAR1遺伝子変異による表現型バリアントである. (2016)
  • Author(s): 河野通浩、松本文博、鈴木保宏、菅沼睦美、才津浩智、伊藤康友、藤原作平、森脇真一、松本和彦、松本直通、富田靖、杉浦一充、秋山真志.
  • Organizer: 第9回自己炎症疾患研究会
  • Place of Presentation: 東京都千代田区（フクラシア東京ステーション）
  • Year and Date: 2016-02-06
• [Presentation] Hyperpigmentation over the metacarpophalangeal joints and the malleoli in a case of hyaline fibromatosis syndrome with ANTXR2 mutations. (2015)
  • Author(s): Sugiura K, Ohno A, Kono M, Kitoh H, Itomi K, Akiyama M.
  • Organizer: 第40回日本研究皮膚科学会
  • Place of Presentation: 岡山県岡山市（岡山コンベンションセンター）
  • Year and Date: 2015-12-11
• [Presentation] Filaggrin gene mutations are significantly associated with food allergy in Japanese primary school children. (2015)
  • Author(s): Kono M, Akiyama M, Nomura T, McLean WHI, Shimizu H, Sugiura K, Hata A, Okamoto Y, Inoue Y, Suzuki Y, Shimojo N.
  • Organizer: 第40回日本研究皮膚科学会
  • Place of Presentation: 岡山県岡山市（岡山コンベンションセンター）
  • Year and Date: 2015-12-11
• [Presentation] NCOA2遺伝子再構成陽性の顔のangiofibroma of soft tissue. (2015)
  • Author(s): Jeong Jin-Wook、村上佳恵、河野通浩、加藤陽一、小沢広明、元井 亨、多田豊曠、秋山真志.
  • Organizer: 第274回日本皮膚科学会東海地方会
  • Place of Presentation: 愛知県名古屋市（大正製薬(株)名古屋支店）
  • Year and Date: 2015-12-06
• [Presentation] 左臀部の黒色結節の一例. (2015)
  • Author(s): 森章一郎、村上佳恵、河野通浩、大城宏治、中黒匡人、秋山真志.
  • Organizer: 第15回東海皮膚病理研究会
  • Place of Presentation: 愛知県名古屋市（エーザイ株式会社 名古屋コミュニケーションオフィス）
  • Year and Date: 2015-12-05
• [Presentation] 左第5趾足底部の腫瘤. (2015)
  • Author(s): 渡邊直樹、河野通浩、横田憲二、松本高明、村上佳恵、秋山真志、下山芳江.
  • Organizer: 第14回東海皮膚病理研究会
  • Place of Presentation: 愛知県名古屋市（ウインクあいち）
  • Year and Date: 2015-08-08
• [Presentation] Epidermolytic ichthyosisの一例. (2015)
  • Author(s): 大村玲奈, 深井和吉, 菅原弘二, 鶴田大輔, 永尾淳, 河野通浩, 秋山真志.
  • Organizer: 第39回小児皮膚科学会学術大会
  • Place of Presentation: 鹿児島県鹿児島市（かごしま県民交流センター）
  • Year and Date: 2015-07-18
• [Presentation] 網状肢端色素沈着症の1例. (2015)
  • Author(s): 堤 美穂、中井章淳、加藤則人、河野通浩.
  • Organizer: 第440回日本皮膚科学会京滋地方会
  • Place of Presentation: 京都府京都市（京都大学）
  • Year and Date: 2015-06-06
• [Presentation] 同一家系内に見られた滴状脱色素斑. (2015)
  • Author(s): 江上将平、本田治樹、横山知明、杉浦丹、河野通浩、秋山真志.
  • Organizer: 第114回日本皮膚科学会総会
  • Place of Presentation: 神奈川県横浜市（パシフィコ横浜）
  • Year and Date: 2015-05-29
• [Presentation] 日本におけるブルーリ潰瘍の疫学と新規治療法の提唱. (2015)
  • Author(s): 村瀬千晶、河野通浩、松本高明、横田憲二、長谷川佳恵、中永和枝、石井則久、秋山真志.
  • Organizer: 第114回日本皮膚科学会総会
  • Place of Presentation: 神奈川県横浜市（パシフィコ横浜）
  • Year and Date: 2015-05-29
• [Presentation] 左頬皮下結節の1例. (2015)
  • Author(s): Jeong Jin-Wook、長谷川佳恵、河野通浩、加藤陽一、秋山真志.
  • Organizer: 第13回東海皮膚病理研究会
  • Place of Presentation: 愛知県名古屋市（名古屋ルーセントタワー）
  • Year and Date: 2015-04-02
• [Presentation] Dowling-Degos disease is genetically and clinico-pathologically distinct from reticulate acropigmentation of Kitamura, further confirmation. (2014)
  • Author(s): Michihiro Kono, Mutsumi Suganuma, Kazumitsu Sugiura, Hiromichi Takama, Tamio Suzuki, Kayoko Matsunaga, Yasushi Tomita and Masashi Akiyama
  • Organizer: 第39回日本研究皮膚科学会
  • Place of Presentation: ホテル阪急エキスポパーク（大阪府吹田市）
  • Year and Date: 2014-12-12 – 2014-12-14
• [Presentation] Reticulate acropigmentation of Kitamura and Dowling-Degos disease are genetically independent disorders distinct from each other; further confirmation (2014)
  • Author(s): Michihiro Kono, Kazumitsu Sugiura, Mutsumi Suganuma, Hiromichi Takama, Tamio Suzuki, Kayoko Matsunaga, Yasushi Tomita and Masashi Akiyama
  • Organizer: XXII International Pigment Cell Conference
  • Place of Presentation: Singapore, Singapore
  • Year and Date: 2014-09-04 – 2014-09-07
• [Presentation] Whole-exome sequencing identifies ADAM10 mutations as a cause of reticulate acropigmentation of Kitamura, a clinical entity distinct from Dowling-Degos disease. (2014)
  • Author(s): 河野通浩
  • Organizer: 第113回日本皮膚科学会総会
  • Place of Presentation: 京都国際会議場（京都府京都市）
  • Year and Date: 2014-05-30 – 2014-06-01
  • Invited
• [Presentation] [教育講演] 皮膚病理へのいざない(第1回) 総論および皮膚腫瘍(Part I) 表皮系良性腫瘍(疣贅を含む)と有棘細胞癌(前駆症を含む) (2013)
  • Author(s): 河野通浩
  • Organizer: 第112回 日本皮膚科学会総会
  • Place of Presentation: パシフィコ横浜、横浜市
  • Invited
• [Presentation] 右臀部の腫瘤 (2013)
  • Author(s): 長谷川佳恵、横田憲二、河野通浩、澤田昌樹、秋山真志
  • Organizer: 第29回 日本皮膚病理組織学会
  • Place of Presentation: 石垣記念ホール、東京都港区
• [Presentation] 臀部粉瘤より発生した有棘細胞癌の一例 (2013)
  • Author(s): 長谷川 佳恵, 横田 憲二, 河野 通浩, 澤田 昌樹, 松本 高明, 秋山 真志
  • Organizer: 第29回 日本皮膚悪性腫瘍学会学術大会
  • Place of Presentation: 甲府富士屋ホテル、甲府市
• [Presentation] 尋常性乾癬を伴わない汎発性膿疱性乾癬の大半はIL-36RN欠損症(DITRA)である (2013)
  • Author(s): 杉浦 一充, 武市 拓也, 河野 通浩, 小川 靖, 室 慶直, 秋山 真志, 武藤 正彦
  • Organizer: 第77回 日本皮膚科学会東部支部学術総会
  • Place of Presentation: 大宮ソニックシティ、大宮市
• [Presentation] 網状肢端色素沈着症はADAM10の遺伝子変異によって発症する (2013)
  • Author(s): 河野 通浩, 杉浦 一充, 富田 靖, 秋山 真志, 林 昌浩, 鈴木 民夫, 高間 弘道, 松永 佳世子
  • Organizer: 第77回 日本皮膚科学会東部支部学術総会
  • Place of Presentation: 大宮ソニックシティ、大宮市
• [Presentation] 常性乾癬を伴わない汎発性膿疱性乾癬の大半はIL-36RN欠損症(DITRA)である (2013)
  • Author(s): 杉浦 一充, 武市 拓也, 河野 通浩, 小川 靖, 室 慶直, 武藤 正彦, 秋山 真志
  • Organizer: 第64回 日本皮膚科学会中部支部学術総会
  • Place of Presentation: 名古屋国際会議場、名古屋市
• [Presentation] 網状肢端色素沈着症はADAM10の遺伝子変異によって発症する (2013)
  • Author(s): 河野 通浩, 杉浦 一充, 林 昌浩, 高間 弘道, 鈴木 民夫, 松永 佳世子, 富田 靖, 秋山 真志
  • Organizer: 第64回 日本皮膚科学会中部支部学術総会
  • Place of Presentation: 名古屋国際会議場、名古屋市
• [Presentation] 免疫抑制状態にある子宮頚癌術後患者に発症したBowen様丘疹症の一例 (2013)
  • Author(s): 澤田昌樹、河野 通浩, 秋山 真志
  • Organizer: 第64回 日本皮膚科学会中部支部学術総会
  • Place of Presentation: 名古屋国際会議場、名古屋市
• [Presentation] 網状肢端色素沈着症はADAM10の遺伝子変異によって発症する (2013)
  • Author(s): 河野 通浩, 杉浦 一充, 林 昌浩, 高間 弘道, 鈴木 民夫, 松永 佳世子, 富田 靖, 秋山 真志
  • Organizer: 第25回 日本色素細胞学会学術大会
  • Place of Presentation: 大阪大学銀杏会館、吹田市
• [Presentation] Novel ADAR1 mutations including single amino acid deletion in the deaminase domain underly dyschromatosis symmetrica hereditaria (2012)
  • Author(s): Michihiro Kono, Yasutomo Ito, Hideyuki Ujiie, Kenichi Morimoto, Masashi Akiyama
  • Organizer: The 36th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 那覇
• [Presentation] 教育講演 皮膚病理へのいざない「上皮系腫瘍」 (2012)
  • Author(s): 河野通浩
  • Organizer: 第111回 日本皮膚科学会総会
  • Place of Presentation: 京都
• [Presentation] 頭部腫瘍の一例 (2012)
  • Author(s): 牧田澄子、山田元人、鈴木教之、唐沢卓生、前田松喜、河野通浩、秋山真志
  • Organizer: 第28回 日本皮膚病理組織学会
  • Place of Presentation: 東京
• [Book] 今日の治療指針2014年度版「酒さ様皮膚炎・口囲皮膚炎」 (2014)
  • Author(s): 河野通浩、戸倉新樹、新谷陽一、天野正宏、川田暁、海老原全、高山かおる、浅野善英、神戸直智、片桐一元、村田哲、佐伯秀久、三原祥嗣、室田浩之、佐藤貴浩、石黒直子、末木博彦、相原道子、赤坂江美子、照井正、他
  • Total Pages: 2052
  • Publisher: 医学書院
• [Book] Dyschromatosis symmetrica hereditaria and RNA editing enzyme. in the book "Current Genetics in Dermatology" (2013)
  • Author(s): Michihiro Kono, Masashi Akiyama.
  • Total Pages: 213
  • Publisher: InTech
• [Remarks] The dyschromatoses. In: UpToDate
  • URL: http://www.uptodate.com/contents/the-dyschromatoses