Investigation of the mechanism and therapy for Japanese cedar pollen dermatitis
Project/Area Number |
24591647
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Dermatology
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Research Institution | Mie University |
Principal Investigator |
MIZUTANI Hitoshi 三重大学, 医学(系)研究科(研究院), 教授 (30115737)
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Co-Investigator(Kenkyū-buntansha) |
YAMANAKA Keiichi 三重大学, 大学院医学系研究科, 准教授 (70314135)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 花粉皮膚炎 / スギ花粉症 / アレルギー / アトピー性皮膚炎 / アレルギー性鼻炎 / IL-10 / Treg / モデルマウス / Th2サイトカイン |
Outline of Final Research Achievements |
We tried development of a mouse model for the Japanese cedar pollen dermatitis (CPD). Immunization with combination of the percutaneous and non-percutaneous application with Japanese cedar pollen antigens successfully sensitized some mice. FACS analysis of the lymphocytes and the skin cytokine mRNA profile of the immunized mouse revealed sensitization in some mouse. However, we have to change the strategy because of the very low sensitization efficiency of this model. Following to human Japanese cedar pollinosis (JCP), we developed a mouse model for JCP by repeated trans-nasal immunization, and successfully developed a Th2 type JCP mouse model. We are analyzing the immunological profile of the JCP model and are developing the CPD model by additional immunization.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Olopatadine, a non-sedating H1 antihistamine, decreases the nocturnal scratching without affecting sleep quality in atopic dermatitis.2015
Author(s)
Yamanaka K, Motomura E, Noro Y, Umeda K, Morikawa T, Umeda-Togami K, Omoto Y, Isoda K, Kondo M, Tsuda K, Okuda M, Gabazza EC, Mizutani H.
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Journal Title
Exp Dermatol.
Volume: 24
Issue: 3
Pages: 227-229
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Persistent release of IL-1s from skin is associated with systemic cardio-vascular disease, emaciation and systemic amyloidosis: the potential of anti-IL-1 therapy for systemic inflammatory diseases.2014
Author(s)
Yamanaka K, Nakanishi T, Saito H, Maruyama J, Isoda K, Yokochi A, Imanaka-Yoshida K, Tsuda K, Kakeda M, Okamoto R, Fujita S, Iwakura Y, Suzuki N, Ito M, Maruyama K, Gabazza EC, Yoshida T, Shimaoka M, Mizutani H.
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Journal Title
PLoS One.
Volume: 9
Issue: 8
Pages: 104479-104479
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Novel acoustic evaluation system for scratching behavior in itching dermatitis: Rapid and accurate analysis for nocturnal scratching of atopic dermatitis patients.2014
Author(s)
Noro Y, Omoto Y, Umeda K, Tanaka F, Shiratsuka Y, Yamada T, Isoda K, Matsubara K, Yamanaka K, Gabazza EC, Nishikawa M, Mizutani H.
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Journal Title
J Dermatol.
Volume: 41
Issue: 3
Pages: 233-238
DOI
Related Report
Peer Reviewed
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[Journal Article] Intranasally administered antigen 85B gene vaccine in non-replicating human Parainfluenza type 2 virus vector ameliorates mouse atopic dermatitis.2013
Author(s)
Kitagawa H, Kawano M, Yamanaka K, Kakeda M, Tsuda K, Inada H, Yoneda M, Sakaguchi T, Nigi A, Nishimura K, Komada H, Tsurudome M, Yasutomi Y, Nosaka T, Mizutani H.
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Journal Title
PLoS One.
Volume: 8
Issue: 7
Pages: 66614-66614
DOI
Related Report
Peer Reviewed
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[Presentation] A new sensitive scratch recorder for human dermatitis: evaluation of nocturnal scratching sound of AD patients2013
Author(s)
Y. Omoto, Y. Noro, K. Matsubara, K. Isoda, K. Umeda, M. Naka, A. Yamagiwa, M. Kondo, T. Akeda, K. Yamanaka, H. Mizutani
Organizer
International Investigative Dermatology 2013
Place of Presentation
Edinburgh
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