Molecular mechanism of fibrosis : involvement of autocrine TGF-beta signaling.

• Project/Area Number: 24591658
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kumamoto University
• Principal Investigator: IHN Hironobu 熊本大学, 生命科学研究部, 教授 (20282634)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 遺伝子 / 細胞・組織 / シグナル伝達

Outline of Final Research Achievements

We identified up-regulated or down-regulated genes using DNA microaary analysis and identified up-regulated or down-regulated microRNAs using microRNA array analysis in fibrosis. We made integrin αVβ5 stable transfectants using normal dermal fibroblasts and confirmed overexpression of extracellular matrix genes and down-regulation of proteases, such as MMP-1. We examined the phenotype of fibroblast-specific integrin αV transgenic mice.

Research Products

• [Journal Article] Fascia lata onlay patch for repairing infected incisional hernias. (2015)
  • Author(s): Miyamoto Y, Watanabe M, Ishimoto T, Baba Y, Iwagami S, Sakamoto Y, Yoshida N, Masuguchi S, Ihn H, Baba H.
  • Journal Title: Surg Today Volume: 45 Pages: 121-124
  • Peer Reviewed
• [Journal Article] Hair shaft microRNA-221 levels as a new tumor marker of malignant melanoma. (2015)
  • Author(s): Inada T, Fukushima S, Murai M, Jinnin M, Miyashita A, Nakahara S, Yamashita J, Aoi J, Msuguchi S, Ihn H.
  • Journal Title: J Dermatol Volume: 42 Pages: 198-201
  • Peer Reviewed
• [Journal Article] Analysis of expression pattern of serum microRNA levels in patients with psoriasis (2014)
  • Author(s): Yusaku Koga; Masatoshi Jinnin; Asako Ichihara; Akihiko Fujisawa; Chikako Moriya; Keisuke Sakai; Satoshi Fukushima; Yuji Inoue; Hironobu Ihn
  • Journal Title: Journal of Dermatological Science Volume: 27 Pages: 170-171
  • Peer Reviewed
• [Journal Article] Association of linear IgA bullous disease with ulcerative colitis: A case of successful treatment with infliximab (2014)
  • Author(s): S. Yamada; T. Makino; M. Jinnin; K. Sakai; S. Fukushima; Y. Inoue; H. Ihn
  • Journal Title: Dermatology Volume: 4 Pages: 295-298
  • Peer Reviewed
• [Journal Article] Dots/globules on dermoscopy in nail-apparatus melanoma (2014)
  • Author(s): Yuji Inoue; Scott W. Menzies; Satoshi Fukushima; Hazuki Nishi-Kogushi; Azusa Miyashita; Shinichi Masukuchi; Faith Muchemwa; Toshiro Kageshita; Hironobu Ihn
  • Journal Title: International Journal of Dermatology Volume: 53 Pages: 88-92
  • Peer Reviewed
• [Journal Article] miR-205 down-regulation promotes proliferation of dermatofibrosarcoma protuberans tumor cells by regulating LRP-1 and ERK phosphorylation (2014)
  • Author(s): Ikko Kajihara; Masatoshi Jinnin; Miho Harada; Katsunari Makino; Noritoshi Honda; Takamitsu Makino; Toshikatsu Igata; Shinichi Masuguchi; Satoshi Fukushima; Hironobu Ihn
  • Journal Title: Archives of Dermatological Research Pages: 1-8
  • Peer Reviewed
• [Journal Article] Phase II study of i.v. interferon-gamma in Japanese patients with mycosis fungoides (2014)
  • Author(s): Makoto Sugaya; Yoshiki Tokura; Toshihisa Hamada; Ryoji Tsuboi; Yoichi Moroi; Takeshi Nakahara; Masahiro Amano; Syuichi Ishida; Daisuke Watanabe; Mamori Tani; Hironobu Ihn; Jun Aoi; Keiji
  • Journal Title: Journal of Dermatology Volume: 41 Pages: 50-56
  • Peer Reviewed
• [Journal Article] MIRSNP rs2910164 of miR-146a is associated with the muscle involvement in polymyositis/dermatomyositis (2014)
  • Author(s): Yoshifumi Okada; Masatoshi Jinnin; Takamitsu Makino; Ikko Kajihara; Katsunari Makino; Noritoshi Honda; Wakana Nakayama; Kuniko Inoue; Satoshi Fukushima; Hironobu Ihn
  • Journal Title: International Journal of Dermatology Volume: 53 Pages: 300-304
  • Peer Reviewed
• [Journal Article] Successful treatment of skin fistulas in systemic sclerosis patients with the combination of topical negative pressure therapy and split-thickness skin grafting (2014)
  • Author(s): Ikko Kajihara; Masatoshi Jinnin; Saori Yamada; Asako Ichihara; Takamitsu Makino; Toshikatsu Igata; Shinichi Masuguchi; Satoshi Fukushima; Hironobu Ihn
  • Journal Title: Modern Rheumatology Volume: 24 Pages: 374-376
  • Peer Reviewed
• [Journal Article] Clinical evaluation of moisturizers with physiological analysis of stratum corneum TARC and TSLP. (2014)
  • Author(s): Fukushima S, Morita E, Tanioka M, Miyachi Y, Murakami Y, Matsunaka H, Ihn H.
  • Journal Title: J Cosmetics, Dermatological Sciences and Applications Volume: 4 Pages: 37-43
  • Peer Reviewed
• [Journal Article] Serum adhesion molecule levels as prognostic markers in patients with early systemic sclerosis: a multicenter, prospective, observational study. (2014)
  • Author(s): Hasegawa M, Asano Y, Endo H, Fujimoto M, Goto D, Ihn H, Inoue K, Ishikawa O, Kawaguchi Y, Kuwana M, Ogawa F, Takahashi H, Tanaka S, Sato S, Takehara K.
  • Journal Title: PLoS One Volume: 9
  • Peer Reviewed
• [Journal Article] Angiopoietin-like protein 2 accelerates carcinogenesis by activating chronic inflammation and oxidative stress. (2014)
  • Author(s): Aoi J, Endo M, Kadomatsu T, Miyata K, Ogata A, Horiguchi H, Odagiri H, Matsuda T, Fukushima S, Jinnin M, Hirakawa S, Sawa T, Akaike T, Ihn H, Oike Y.
  • Journal Title: Mol Cancer Res Volume: 12 Pages: 239-247
  • Peer Reviewed
• [Journal Article] A case of psoriasis accompanied by arthritis after delivery. (2014)
  • Author(s): Kanemaru H, Jinnin M, Asao A, Ichihara A, Makino K, Kajihara I, Fujisawa A, Fukushima S, Ihn H.
  • Journal Title: BioScience Trends Volume: 8 Pages: 64-67
  • Peer Reviewed
• [Journal Article] Case of Fusarium paronychia successfully treated with occulisive dressing of antifungal cream. (2014)
  • Author(s): Ikeda I, Ohno T, Ohno H, Miyazaki Y, Nishimoto K, Makino T, Ihn H.
  • Journal Title: J Dermatol Volume: 41 Pages: 340-342
  • Peer Reviewed
• [Journal Article] Up-regulation of miR-18a contributes to the epidermal necrolysis in severe drug eruptions. (2014)
  • Author(s): Ichihara A, Wang Z, Jinnin M, Izono Y, Shimozono N, Yamane K, Fujisawa A, Moriya C, Fukushima S, Inoue Y, Ihn H.
  • Journal Title: J Allergy Clin Immunol Volume: 133 Pages: 1065-1074
  • Peer Reviewed
• [Journal Article] Effects of the immunosuppressant rapamycin on the expression of human α2(I) collagen and matrix metalloproteinase 1 genes in scleroderma dermal fibroblasts. (2014)
  • Author(s): Tamaki Z, Asano Y, Kubo M, Ihn H, Tada Y, Sugaya M, Kadono T, Sato S.
  • Journal Title: J Dermatol Sci Volume: 74 Pages: 251-259
  • Peer Reviewed
• [Journal Article] miR-424 levels in hair shaft are increased in psoriasis patients. (2014)
  • Author(s): Tsuru Y, Jinnin M, Ichihara A, Fujisawa A, Moriya C, Sakai K, Fukushima S, Ihn H
  • Journal Title: J Dermatol Volume: 41 Pages: 382-385
  • Peer Reviewed
• [Journal Article] Case of disseminated cutaneous Mycobacterium chelonae infection mimicking cutaneous vasculitis. (2014)
  • Author(s): Ichihara A, Jinnin M, Fukushima S, Inoue Y, Ihn H.
  • Journal Title: J Dermatol Volume: 41 Pages: 414-417
  • Peer Reviewed
• [Journal Article] Knockout of endothelial cell-derived endothelin-1 attenuates skin fibrosis but accelerate cutaneous wound healing. (2014)
  • Author(s): Makino K, Jinnin M, Aoi J, Kajihara I, Makino T, Fukushima S, Sakai K, Nakayama K, Emoto N, Yanagisawa M, Ihn H.
  • Journal Title: PLoS One Volume: 9
  • Peer Reviewed
• [Journal Article] Decreased IL-20 expression in scleroderma skin contributes to cutaneous fibrosis. (2014)
  • Author(s): Kudo H, Jinnin M, Asano Y, Trojanowska M, Nakayama W, Inoue K, Honda N, Kajihara I, Makino K, Fukushima S, Ihn H.
  • Journal Title: Arthritis Rheumatol Volume: 65 Pages: 1636-1647
  • Peer Reviewed
• [Journal Article] Evaluation of sentinel node biopsy for cutaneous squamous cell carcinoma. (2014)
  • Author(s): Fukushima S, Masuguchi S, Igata T, Harada M, Aoi J, Miyashita A, Nakahara S, Inoue Y, Jinnin M, Shiraishi S, Yamashita Y, Ishihara T, Ihn H.
  • Journal Title: J Dermatol Volume: 41 Pages: 539-541
  • Peer Reviewed
• [Journal Article] Immunoglobulin G4-related disease in a psoriasis vulgaris patient treated with ustekinumab. (2014)
  • Author(s): Kajihara I, Makino K, Ichihara A, Fukushima S, Jinnin M, Hirooka S, Kojima K, Kourogi H, Ihn H.
  • Journal Title: J Dermatol Volume: 41 Pages: 670-671
  • Peer Reviewed
• [Journal Article] Serum levels of soluble carbonic anhydrase IX are decreased in patients with diffuse cutaneous systemic sclerosis compared to those with limited cutaneous systemic sclerosis. (2014)
  • Author(s): Makino K, Jinnin M, Makino T, Kajihara I, Fukushima S, Inoue Y, Ihn H.
  • Journal Title: Biosci Trends Volume: 8 Pages: 144-148
  • Peer Reviewed
• [Journal Article] Clincal significance of serum vascular endothelial-cadherin levels in inflammatory skin diseases. (2014)
  • Author(s): Kuriyama H, Jinnin M, Kanemaru H, Ichihara A, Fujisawa A, Moriya C, Fukushima S, Ihn H.
  • Journal Title: Ann Dermatol Volume: 26 Pages: 536-538
  • Peer Reviewed
• [Journal Article] Serum levels of matrix metalloproteinase-13 in patients with eosinophilic fasciitis. (2014)
  • Author(s): Asano Y, Ihn H, Jinnin M, Tamaki Z, Tamaki K, Sato S.
  • Journal Title: J Dermatol Volume: 41 Pages: 746-748
  • Peer Reviewed
• [Journal Article] The proportion of lymphocytic inflammation with CD123-positive cells in lupus erythematosus profundus predict a clinical response to treatment. (2014)
  • Author(s): Miyashita A, Fukushima S, Makino T, Yoshino Y, Yamashita J, Honda N, Aoi J, ,Ichihara A, Jinnin M, Inoue Y, Ihn H.
  • Journal Title: Acta Derm Venereol Volume: 94 Pages: 563-567
  • Peer Reviewed
• [Journal Article] Transcriptionally controlled tumor protein is a novel biologic target for neurofibromatosis type I (NF-1) -associated tumors. (2014)
  • Author(s): Kobayashi D, Hirayama M, Komohara Y, Mizuguchi S, Wilson Morifuji M, Ihn H, Takeya M, Kuramochi A, Araki N.
  • Journal Title: J Biol Chem Volume: 289 Pages: 26314-26326
  • Peer Reviewed
• [Journal Article] Down-regulation of microRNA-196a in the sera and involved skin of localized scleroderma patients. (2014)
  • Author(s): Makino T, Jinnin M, Etoh M, Yamane K, Kajihara I, Makino K, Ichihara A, Igata T, Sakai K, Fukushima S, Ihn H.
  • Journal Title: Eur J Dermatol Volume: 24 Pages: 470-476
  • Peer Reviewed
• [Journal Article] Serum levels of leptin receptor in patients with systemic sclerosis. (2014)
  • Author(s): Ohyoshi Y, Makino T, Jinnin M, Nakayama W, Fukushima S, Inoue Y, Ihn H.
  • Journal Title: Intractable Rare Dis Res Volume: 2 Pages: 55-58
  • Peer Reviewed
• [Journal Article] A simple and effective reconstructive technique for repairing defects of the upper lip using a hatchet flap. (2014)
  • Author(s): Aoi J, Nagatomo E, Masuguchi S, Fukushima S, Jinnin M, Ihn H.
  • Journal Title: J Dermatol Volume: 41 Pages: 1025-1026
  • Peer Reviewed
• [Journal Article] A case of anaplastic large cell lymphoma of skeletal muscle. (2014)
  • Author(s): Kubo Y, Jono T, Makino T, Sakai K, Masuguchi S, Fukushima S, Jinnin, Inoue Y, Ihn H.
  • Journal Title: J Dermatol Volume: 41 Pages: 999-1002
  • Peer Reviewed
• [Journal Article] Aesthethic reconstruction of defects in the lateral side wall of the nose using a local V-Y flap. (2014)
  • Author(s): Aoi J, Masuguchi S, Fukushima S, Jinnin M, Ihn H.
  • Journal Title: J Dermatol Volume: 41 Pages: 1026-1028
  • Peer Reviewed
• [Journal Article] Increased CCL22 expression in psoriatic skin predicts a good response to infliximab therapy. (2014)
  • Author(s): Kusumoto S, Kajihara I, Nagatomo E, Makino K, Ichihara A, Aoi J, Johno T, Makino T, Fukushima S, Jinnin M, Ihn H.
  • Journal Title: Br J Dermatol Volume: 171 Pages: 1259-1261
  • Peer Reviewed
• [Journal Article] The expression profile of the toll-like receptor family in scleroderma dermal fibroblasts. (2014)
  • Author(s): Sakoguchi A, Nakayama W, Jinnin M, Wang Z, Yamane K, Aoi J, Makino K, Kajihara I, Ichihara A, Makino T, Fukushima S, Sakai K, Inoue Y, Ihn H.
  • Journal Title: Clin Exp Rheumatol Volume: 32
• [Journal Article] Tsukushi is involved in the wound healing by regulating the expression of cytokines and growth factors. (2014)
  • Author(s): Niimori D, Kawano R, Niimori-Kita K, Ihn H, Ohta K.
  • Journal Title: J Cell Commun Signal Volume: 8 Pages: 173-177
  • Peer Reviewed
• [Journal Article] Clinical features of 80 cases with tinea faciei treated at a rural clinic in Japana. (2014)
  • Author(s): Noguchi H, Jinnin M, Miyata K, Hiruma M, Ihn H.
  • Journal Title: Drug Discov Ther Volume: 8 Pages: 245-248
  • Peer Reviewed
• [Journal Article] Clinical evaluation of moisturizers with physiological analysis of stratum corneum TARC and TSLP. (2014)
  • Author(s): Fukushima S, Morita E, Tanioka M, Miyachi Y, Murakami Y, Matsunaka H, Ihn H.
  • Journal Title: J Cosmetics, Dermatological Sciences and Applications, Volume: 4 Pages: 37-43
  • Peer Reviewed
• [Journal Article] Phase II study of i.v. interferon- gamma in Japanese patient s with mycosis fungoides. (2014)
  • Author(s): Sugaya M, Tokura Y, Hamada T, Tsuboi R, Moroi Y, Nakahara T, Amano M, Ishida S, Watanabe D, Tani M, Ihn H, Aoi J, Iwatsuki K.
  • Journal Title: J Dermatol, Volume: 41 Pages: 50-56
  • Peer Reviewed
• [Journal Article] Dots/ globules on dermoscopy in nail-apparatus melanoma. (2014)
  • Author(s): Inoue Y, Menzies SW, Fukushima S, Nishi-Kogushi H, Miyashita A, Masuguchi S, Muchemwa F, Kageshita T, Ihn H.
  • Journal Title: Int J Dermatol Volume: 53 Pages: 88-92
  • Peer Reviewed
• [Journal Article] Successful treatment of skin fistulas in systemic sclerosis patients with the combination of topical negative pressure therapy and split-thickness skin grafting. (2014)
  • Author(s): Kajihara I, Jinnin M, Yamada S, Ichihara A, Makino T, Igata T, Masuguchi S, Fukushima S, Ihn H.
  • Journal Title: Mod Rheumatol, Volume: 24 Pages: 374-376
  • Peer Reviewed
• [Journal Article] Angiopoietin-like protein 2 accelerates carcinogenesis by activating chronic inflammation and oxidative stress. (2014)
  • Author(s): Aoi J, Endo M, Kadomatsu T, Miyata K, Ogata A, Horiguchi H, Odagiri H, Matsuda T, Fukushima S, Jinnin M, Hirakawa S, Sawa T, Akaike T, Ihn H, Oike Y.
  • Journal Title: Mol Cancer Res, Volume: 12 Pages: 239-249
  • Peer Reviewed
• [Journal Article] MIRSNP rs2910164 of miR-146a is associated with the muscle involvement in polymyositis/ dermatomyositis. (2014)
  • Author(s): Okada Y, Jinnin M, Makino T, Kajihara I, Makino K, Honda N, Nakayama W, Inoue K, Fukushima S, Ihn H.
  • Journal Title: Int J Dermatol, Volume: 53 Pages: 300-304
  • Peer Reviewed
• [Journal Article] Case of Fusarium paronychia successfully treated with occulisive dressing of antifungal cream. (2014)
  • Author(s): Ikeda I, Ohno T, Ohno H, Miyazaki Y, Nishimoto K, Makino T, Ihn H.
  • Journal Title: J Dermatol, Volume: 41 Pages: 340-342
  • Peer Reviewed
• [Journal Article] Analysis of expression pattern of serum microRNA levels in each patient with psoriasis. (2014)
  • Author(s): Koga Y, Jinnin M, Ichihara A, Fujisawa A, Moriya C, Sakai K, Fukushima S, Inoue Y, Ihn H.
  • Journal Title: J Dermatol Sci, Volume: in press
  • Peer Reviewed
• [Journal Article] Serum levels of leptin receptor in patients with systemic sclerosis. (2014)
  • Author(s): Ohyoshi Y, Makino T, Nakayama W, Fukushima S, Inoue Y, Jinnin M, Ihn H.
  • Journal Title: Rheumatol Int, Volume: in press
  • Peer Reviewed
• [Journal Article] Up-regulation of miR-18a contributes to the epidermal necrolysis in severe drug eruptions. (2014)
  • Author(s): Ichihara A, Wang Z, Jinnin M, Izono Y, Shimozono N, Yamane K, Fujisawa A, Moriya C, Fukushima S, Inoue Y, Ihn H.
  • Journal Title: J Allergy Clin Immunol, Volume: in press
  • Peer Reviewed
• [Journal Article] Sensitive detection of melanoma metastasis utilizing circulating microRNA expression profiles. (2014)
  • Author(s): Shiiyama R, Fukushima S, Jinnin M, Yamashita J, Miyashita A, Nakahara S, Kogi A, Aoi J, Masuguchi S, Inoue Y, Ihn H.
  • Journal Title: Melanoma Res, Volume: in press
  • Peer Reviewed
• [Journal Article] Proportion of lymphocytic inflammation with CD123 positive cells in lupus erythematosus profundus predict a clinical response to treatment. (2014)
  • Author(s): Miyashita A, Fukushima S, Makino T, Yoshino Y, Yamashita J, Honda N, Aoi J, ,Ichihara A, Jinnin M, Ihn H
  • Journal Title: Acta Derm Venereol, Volume: in press
  • Peer Reviewed
• [Journal Article] miR-205 down-regulation promotes proliferation of dermatofibrosarcoma protuberans tumor cells by regulating LRP-1 and ERK phosphorylation. (2014)
  • Author(s): Kajihara I, Jinnin M, Harada M, Makino K, Honda N, Makino T, Igata T, Masuguchi S, Fukushima S, Ihn H.
  • Journal Title: Arch Dermatol Res, Volume: in press
  • Peer Reviewed
• [Journal Article] Decreased IL-20 expression in scleroderma skin contributes to cutaneous fibrosis. (2014)
  • Author(s): Kudo H, Jinnin M, Asano Y, Trojanowska M, Nakayama W, Inoue K, Honda N, Kajihara I, Makino K, Fukushima S, Ihn H.
  • Journal Title: Arthritis Rheumatol, Volume: in press
  • Peer Reviewed
• [Journal Article] Effects of the immunosuppressant rapamycin on the expression of human α2(I) collagen and matrix metalloproteinase 1 genes in scleroderma dermal fibroblasts. (2014)
  • Author(s): Tamaki Z, Asano Y, Kubo M, Ihn H, Tada Y, Sugaya M, Kadono T, Sato S.
  • Journal Title: J Dermatol Sci, Volume: in press
  • Peer Reviewed
• [Journal Article] miR-424 levels in hair shaft are increased in psoriasis patients. (2014)
  • Author(s): Tsuru Y, Jinnin M, Ichihara A, Fujisawa A, Moriya C, Sakai K, Fukushima S, Ihn H.
  • Journal Title: J Dermatol, Volume: in press
  • Peer Reviewed
• [Journal Article] Clinical significance of serum VE-cadherin concentrations in inflammatory skin diseases. (2014)
  • Author(s): Kuriyama H, Jinnin M, Kanemaru H, Ichihara A, Fujisawa A, Moriya C, Fukushima S, Ihn H.
  • Journal Title: Ann Dermatol, Volume: in press
  • Peer Reviewed
• [Journal Article] miR-150 down-regulation contributes to the constitutive type I collagen overexpression in scleroderma dermal fibroblasts via the induction of integrin β3. (2013)
  • Author(s): Honda N, Jinnin M, Kira-Etoh T, Makino K, Kajihara I, Makino T, Fukushima S, Inoue Y, Okamoto Y, Hasegawa M, Fujimoto M, Ihn H.
  • Journal Title: Am J Pathol, Volume: 182 Pages: 206-216
  • Peer Reviewed
• [Journal Article] The rs2910164 G>C polymorphism in microRNA-146a is associated with the incidence of malignant melanoma. (2013)
  • Author(s): Yamashita J, Iwakiri T, Fukushima S, Jinnin M, Miyashita A, Hamasaki T, Makino T, Aoi J, Masuguchi S, Inoue Y, Ihn H.
  • Journal Title: Melanoma Res, Volume: 23 Pages: 13-20
  • Peer Reviewed
• [Journal Article] The miR-146a rs2910164G/C polymorphism is associated with telangiectasia in systemic sclerosis. (2013)
  • Author(s): Sakoguchi A, Jinnin M, Makino T, Kajihara I, Makino K, Honda N, Nakayama W, Inoue K, Fukushima S, Ihn H.
  • Journal Title: Clin Exp Dermatol, Volume: 38 Pages: 99-100
  • Peer Reviewed
• [Journal Article] microRNA-7 down-regulation mediates excess collagen expression in localized scleroderma. (2013)
  • Author(s): Etoh M, Jinnin M, Makino K, Yamane K, Nakayama W, Aoi J, Honda N, Kajihara I, Makino T, Fukushima S, Ihn H.
  • Journal Title: Arch Dermatol Res, Volume: 305 Pages: 9-15
  • Peer Reviewed
• [Journal Article] Down-regulation of miR-124/ -214 in cutaneous squamous cell carcinoma mediates abnormal cell proliferation via the induction of ERK. (2013)
  • Author(s): Yamane K, Jinnin M, Etoh T, Kobayashi Y, Shimozono N, Fukushima S, Masuguchi S, Maruo K, Inoue Y, Ishihara T, Aoi J, Oike Y, Ihn H.
  • Journal Title: J Mol Med, Volume: 91 Pages: 69-81
  • Peer Reviewed
• [Journal Article] Intravenous immunoglobulin treatment recovers the down-regulatied levels of Th1 cytokines in the sera and skin of scleroderma patients. (2013)
  • Author(s): Kudo H, Jinnin M, Yamane K, Makino T, Kajihara I, Makino K, Honda N, Nakayama W, Fukushima S, Ihn H.
  • Journal Title: J Dermatol Sci, Volume: 69 Pages: 77-80
  • Peer Reviewed
• [Journal Article] Diccoidin domain receptor 2-micro RNA 196a -mediated negative feedback against excess type I collagen expression is impaired in scleroderma dermal fibroblasts. (2013)
  • Author(s): Makino K, Jinnin M, Aoi J, Hirano A, Kajihara I, Makino T, Sakai K, Fukushima S, Inoue Y, Ihn H.
  • Journal Title: J Invest Dermatol, Volume: 133 Pages: 110-119
  • Peer Reviewed
• [Journal Article] Serum epidermal growth factor receptor levels in patients with malignant melanoma. (2013)
  • Author(s): Kanemura H, Fukushima S, Yamashita J, Jinnin M, Sakai K, Masuguchi M, Aoi J, Makino T, Inoue Y, Ihn H.
  • Journal Title: Clin Exp Dermatol, Volume: 38 Pages: 172-177
  • Peer Reviewed
• [Journal Article] Serum miR-21 levels in patients with dermatomyositis. (2013)
  • Author(s): Shimada S, Jinnin M, Ogata A, Makino T, Kajihara I, Makino K, Honda N, Nakayama W, Inoue K, Fukushima S, Ihn H.
  • Journal Title: Clin Exp Rheumatol, Volume: 31 Pages: 161-162
  • Peer Reviewed
• [Journal Article] Serum levels of interleukin-1α in patients with systemic sclerosis. (2013)
  • Author(s): Maekawa T, Jinnin M, Ohtsuki M, Ihn H.
  • Journal Title: J Dermatol, Volume: 40 Pages: 98-101
  • Peer Reviewed
• [Journal Article] Suppresion of UV-induced wrinkle formation by induction of HSP70 expression in mice. (2013)
  • Author(s): Matsuda M, Hoshino T, Yamakawa N, Tahara K, Adachi H, Sobue G, Maji D, Ihn H, Mizushima T.
  • Journal Title: J Invest Dermatol, Volume: 133 Pages: 919-928
  • Peer Reviewed
• [Journal Article] Hidradenocarcinoma showing prominent mucinous and squamous differentiation and associated with pgetoid cells. (2013)
  • Author(s): Honda Y, Tanigawa H, Harada M, Fukushima S, Masuguchi S, Ishihara T, Ihn H, Iyama K.
  • Journal Title: J Cutan Pathol, Volume: 40 Pages: 503-506
  • Peer Reviewed
• [Journal Article] Case of paraneoplastic pemphigus with follicular lymphoma treated with rituximab. (2013)
  • Author(s): Aoi J, Makino K, Sakai K, Masuguchi S, Fukushima S, Jinnin M, Inoue Y, Koga H, Hashimoto T, Ihn H
  • Journal Title: J Dermatol, Volume: 40 Pages: 285-256
  • Peer Reviewed
• [Journal Article] The down-regulation of microRNA let-7a contributes to the excessive expression of type I collagen in systemic and localized scleroderma. (2013)
  • Author(s): Makino K, Jinnin M, Hirano A, Yamane K, Eto M, Kusano T, Honda N, Kajihara K, Makino T, Sakai K, Masuguchi S, Fukushima S, Ihn H.
  • Journal Title: J Immunol, Volume: 190 Pages: 3905-3915
  • Peer Reviewed
• [Journal Article] Down-regulation of miR-223 contributes to the formation of Gottron’s eruption in dermatomyositis via the induction of PKCε (2013)
  • Author(s): Inoue K, Jinnin M, Yamane K, Makino T, Kajihara I, Makino K, Honda N, Nakayama W, Fukushima S, Ihn H.
  • Journal Title: Eur J Dermatol, Volume: 23 Pages: 160-167
  • Peer Reviewed
• [Journal Article] Pyodermatitis vegetans associated with multiple myeloma. (2013)
  • Author(s): Kajihara I, Ichihara A, Higo J, Kidou M, Ihn H.
  • Journal Title: J Dermatol, Volume: 40 Pages: 222-223
  • Peer Reviewed
• [Journal Article] Decreased miR-7 expression in the skin and sera of patients with dermatomyositis. (2013)
  • Author(s): Oshikawa Y, Jinnin M, Makino T, Kajihara I, Makino K,Honda N, Nakayama W, Inoue K, Fukushima S, Ihn H.
  • Journal Title: Acta Derm Venereol, Volume: 93 Pages: 273-276
  • Peer Reviewed
• [Journal Article] Expression analysis of multiple microRNAs in each patient with scleroderma (2013)
  • Author(s): Koba S, Jinnin M, Inoue K, Nakayama W, Honda N, Makino K, Kajihara I, Makino T, Fukushima S, Ihn H.
  • Journal Title: Exp Dermatol, Volume: 22 Pages: 489-491
  • Peer Reviewed
• [Journal Article] Scleroderma dermal fibroblasts overexpress vascular endothelial growth factor due to autocrine transforming growth factor βsignaling. (2013)
  • Author(s): Kajihara I, Jinnin M, Honda N, Makino K, Makino T, Masuguchi S, Sakai K, Fukushima S, Inoue Y, Ihn H.
  • Journal Title: Mod Rheumatol, Volume: 23 Pages: 516-524
  • Peer Reviewed
• [Journal Article] Geographical flushing of the children’s face: A new clinical entity. (2013)
  • Author(s): Jinnin M, Fukushima S, Inoue Y, Ihn H.
  • Journal Title: Case Rep Dermatol Med, Volume: - Pages: 802130-802130
  • Peer Reviewed
• [Journal Article] A randomized, double-blind, placebo-controlled trial: intravenous immunoglobulin treatment in patients with diffuse cutaneous systemic sclerosis. (2013)
  • Author(s): Takehara K, Ihn H, Sato S.
  • Journal Title: Clin Exp Rheum, Volume: 31 Pages: 151-156
  • Peer Reviewed
• [Journal Article] Serum levels of tenascin-C in collagen diseases. (2013)
  • Author(s): Inoue K, Jinnin M, Hara Y, Makino K, Kajihara I, Makino T, Sakai K, Fukushima S, Inoue Y, Ihn H.
  • Journal Title: J Dermatol, Volume: 40 Pages: 715-719
  • Peer Reviewed
• [Journal Article] Case of neuro-Behcet’s disease successfully maintained a remission using infliximab for 2 years. (2013)
  • Author(s): Kanemaru H, Makino T, Jinnin M, Yonemitsu A, Makino K, Ihn H.
  • Journal Title: J Dermatol, Volume: 40 Pages: 632-4
  • Peer Reviewed
• [Journal Article] Role of c-Jun N-termainal kinase isoforms in the cellular activity of melanoma cell lines. (2013)
  • Author(s): Kogushi-Nishi M, Jinnin M, Kobayashi Y, Muchemwa FC, Hirano A, Makino T, Fukushima S, Masuguchi S, Ihsihara T, Ihn H.
  • Journal Title: Clin Exp Dermatol, Volume: 38 Pages: 890-896
  • Peer Reviewed
• [Journal Article] Association of linear IgA bullous disease with ulcerative colitis: A case of successful treatment with infliximab. (2013)
  • Author(s): Yamada S, Makino T, Jinnin M, Sakai K, Fukushima S, Inoue Y, Ihn H.
  • Journal Title: Dermatology, Volume: 227 Pages: 295-298
  • Peer Reviewed
• [Journal Article] Detection of hair root miR-19a as a novel diagnostic marker for psoriasis. (2013)
  • Author(s): Hirao H, Jinnin M, Ichihara A, Fujisawa A, Makino K, Kajihara I, Sakai K, Fukushima S, Inoue Y, Ihn H.
  • Journal Title: Eur J Dermatol Volume: 23 Pages: 807-811
  • Peer Reviewed
• [Journal Article] Hair miR-29a levels are decreased in patients with scleroderma. (2013)
  • Author(s): Takemoto R, Jinnin M, Wang Z, Kudo H, Inoue K, Nakayama W, Ichihara A, Igata T, Kajihara I, Fukushima S, Ihn H.
  • Journal Title: Exp Dermatol, Volume: 22 Pages: 832-849
  • Peer Reviewed
• [Journal Article] Detection of hair-microRNAs as the novel potent biomarker: Evaluation of the usefulness for the diagnosis of scleroderma. (2013)
  • Author(s): Wang Z, Jinnin M, Kudo H, Inoue K, Nakayama W, Honda N, Makino K, Kajihara I, Fukushima S, Inoue Y, Ihn H.
  • Journal Title: Detection of hair-microRNAs as the novel potent biomarker: Evaluation of the usefulness for the diagnosis of scleroderma. Volume: 72 Pages: 134-141
  • Peer Reviewed
• [Journal Article] Serum chemokine levels as prognostic markers in patients with early systemic sclerosis: a multicentre, prospective, observational study. (2013)
  • Author(s): Hasegawa M, Asano Y, Endo H, Fujimoto M, Goto D, Ihn H, Inoue K, Ishikawa O, Kawaguchi Y, Kuwana M, Ogawa F, Takahashi H, Tanaka S, Sato S, Takehara K.
  • Journal Title: Mod Rheumatol, Volume: 23 Pages: 1076-1084
  • Peer Reviewed
• [Journal Article] CEA (carcinoembryonic antigen) and CEACAM6 (CEA-related cell adhesion molecule 6) are expressed in psoriasis vulgaris. (2013)
  • Author(s): Fujisawa A, Egawa K, Honda Y, Kuroki M, Jinnin M, Ihn H.
  • Journal Title: The Open Dermatol J Volume: 7 Pages: 47-52
  • Peer Reviewed
• [Journal Article] Serum levels of leptin receptor in patients with malignant melanoma as a new tumor marker. (2013)
  • Author(s): Mizutani H, Fukushima S, Masuguchi S, Yamashita J, Miyashita A, Nakahara S, Aoi J, Inoue Y, Jinnin M, Ihn H.
  • Journal Title: Exp Dermatol, Volume: 22 Pages: 748-749
  • Peer Reviewed
• [Journal Article] 創傷・熱傷ガイドライン (2013)
  • Author(s): 尹 浩信
  • Journal Title: Asahi Medical Volume: 42 Pages: 71-73
• [Journal Article] 乾癬治療における生物学的製剤の適応と使い方 (2013)
  • Author(s): 尹 浩信
  • Journal Title: 日経CME Volume: 1 Pages: 1-6
• [Journal Article] 実地医科のための強皮症早期診断とガイドラインの考え方 (2013)
  • Author(s): 尹 浩信、藤本 学、佐藤伸一
  • Journal Title: マルホ皮膚科セミナー Volume: 224 Pages: 4-12
• [Journal Article] 関節症性乾癬へのアプローチ (2013)
  • Author(s): 尹 浩信
  • Journal Title: 日経CME Volume: 2 Pages: 1-6
• [Journal Article] 褥瘡治療の最近の進歩 褥瘡ガイドラインをどう生かすか？ (2013)
  • Author(s): 尹 浩信
  • Journal Title: Geriat. Med. Volume: 51 Pages: 1273-1279
• [Journal Article] Diccoidin domain receptor 2 -micro RNA 196a -mediated negative feedback against excess type I collagen expression is impaired in scleroderma dermal fibroblasts. (2013)
  • Author(s): Makino K, Jinnin M, Aoi J, Hirano A, Kajihara I, Makino T, Sakai K, Fukushima S, Inoue Y, Ihn H.
  • Journal Title: J Invest Dermatol, Volume: 133 Pages: 110-119
  • Peer Reviewed
• [Journal Article] Decreased miR-7 expression in the skin and sera of patients with dermatomyositis. (2013)
  • Author(s): Oshikawa Y, JInnin M, Makino T, Kajihara I, Makino K,Honda N, Nakayama W, Inoue K, Fukushima S, Ihn H.
  • Journal Title: Acta Derm Venereol Volume: 4
  • Peer Reviewed
• [Journal Article] Hidradenocarcinoma showing prominent mucinous and squamous differentiation and associated with pgetoid cells. (2013)
  • Author(s): Honda Y, Tanigawa H, Harada M, Fukushima S, Masuguchi S, Ishihara T, Ihn H, Iyama KI.
  • Journal Title: J Cutan Pathol, Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Dots/ globules on dermoscopy in nail-apparatus melanoma. (2013)
  • Author(s): Inoue Y, Menzies SW, Fukushima S, Nishi-Kogushi H, Miyashita A, Masuguchi S, Muchemwa F, Kageshita T, Ihn H.
  • Journal Title: Int J Dermatol, Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Scleroderma dermal fibroblasts overexpress vascular endothelial growth factor due to autocrine transforming growth factor  signaling. (2013)
  • Author(s): Kajihara I, Jinnin M, Honda N, Makino K, Makino T, Masuguchi S, Sakai K, Fukushima S, Inoue Y, Ihn H.
  • Journal Title: Mod Rheumatol, Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Serum chemokine levels as prognostic markers in patients with early systemic sclerosis: a multicentre, prospective, observational study. (2013)
  • Author(s): Hasegawa M, Asano M, Endo H, Fujimoto M, Goto D, Ihn H, Inoue K, Ishikawa O, Kawaguchi Y, Kuwana M, Ogawa F, Takahashi H, Tanaka S, Sato S, Takehara K.
  • Journal Title: Mod Rheumatol, Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Case of paraneoplastic pemphigus with follicular lymphoma treated with rituximab. (2013)
  • Author(s): Aoi J, Makino K, Sakai k, Masuguchi S, Fukushima S, Jinnin M, Inoue Y, Koga H, Hashimoto T, Ihn H.
  • Journal Title: J Dermatol, Volume: 40 Pages: 285-286
  • Peer Reviewed
• [Journal Article] The down-regulation of microRNA let-7a contributes to excessive expression of type I collagen in systemic and localized scleroderma. (2013)
  • Author(s): Makino K, Jinnin M, Hirano A, Yamane K, Eto M, Kusano T, Honda N, Kajihara K, Makino T, Sakai K, Masuguchi S, Fukushima S, Ihn H.
  • Journal Title: J Immunol, Volume: 190 Pages: 3905-3915
  • Peer Reviewed
• [Journal Article] Clinical significance of cobble stone appearance on the skin of patients with systemic sclerosis. (2012)
  • Author(s): Kajihara I, Jinnin M, Makino T, Toihata-Yonemitsu A, Sakai K, Masuguchi S, Fukushima S, Ihn H.
  • Journal Title: J Eur Acad Dermatol Venereol, Volume: 26 Pages: 123-125
  • Peer Reviewed
• [Journal Article] Investigation of prognostic factors for skin sclerosis and lung function in Japanese patients with systemic sclerosis: a multicenter prospective observational study. (2012)
  • Author(s): Hasegawa M, Asano Y, Endo H, Fujimoto M, Goto D, Ihn H, Inoue K, Ishikawa O, Kawaguchi Y, Kuwana M, Muro Y, Ogawa F, Sasaki T, Takahashi H, Tanaka S, Takehara K, Sato S.
  • Journal Title: Rheumatology, Volume: 51 Pages: 129-133
  • Peer Reviewed
• [Journal Article] Prediction of additional lymph node positivity and clinical outcome of micrometastases in sentinel lymph nodes in cutaneous melanoma: A multi-institutional study of 450 patients in Japan. (2012)
  • Author(s): Namikawa K, Yamazaki N, Nakai Y, Ihn H, Tomita Y, Uhara H, Takenouchi T, Kiyohara Y, Moroi Y, Yamamoto Y, Otsuka F, Kamiya H, Iizuka H, Hatta N, Kadono T.
  • Journal Title: J Dermatol, Volume: 39 Pages: 130-137
  • Peer Reviewed
• [Journal Article] Serum levels of soluble CD21 in patients with sclerosis. (2012)
  • Author(s): Tomita M, Kadono T, Yazawa N, Kawashima T, Tamaki Z, Ashida R, Ohmatsu H, Asano Y, Sugaya M, Kubo M, Ihn H, Tamaki K, Sato S.
  • Journal Title: Rheumatol Int, Volume: 32 Pages: 317-321
  • Peer Reviewed
• [Journal Article] Serum levels of soluble CD163 in patients with systemic sclerosis. (2012)
  • Author(s): Nakayama W, Jinnin M, Makino K, Kajihara I, Makino T, Fukushima S, Inoue Y, Ihn H.
  • Journal Title: Rheumatol Int, Volume: 32 Pages: 403-407
  • Peer Reviewed
• [Journal Article] Increased accumulation of thrombospondin-2 due to low degradation activity stimulates type I collagen expression in scleroderma fibroblasts. (2012)
  • Author(s): Kajihara I, Jinnin M, Yamane K, Makino T, Honda N, Igata T, Masuguchi S, Fukushima S, Okamoto Y, Hasegawa M, Fujimoto M, Ihn H.
  • Journal Title: Am J Pathol, Volume: 180 Pages: 703-714
  • Peer Reviewed
• [Journal Article] Cutaneous type adult T-cell leukemia/lymphoma successfully treated with narrow-band ultraviolet B phototherapy. (2012)
  • Author(s): Kudo K, Fukushima S, Masuguchi S, Sakai K, Jinnin M, Ihn H.
  • Journal Title: Clin Exp Dermatol, Volume: 37 Pages: 183-184
  • Peer Reviewed
• [Journal Article] The role of angiopoietin-like protein 2 in pathogenesis of dermatomyositis. (2012)
  • Author(s): Ogata A, Endo M, Aoi J, Takahashi O, Kadomatsu T, Miyata K, Tian Z, Jinnin M, Fukushima S, Ihn H, Oike Y.
  • Journal Title: Biochem Biophys Res Commun, Volume: 418 Pages: 494-499
  • Peer Reviewed
• [Journal Article] Circulating miR-142-3p levels in patients with systemic sclerosis. (2012)
  • Author(s): Makino K, Jinnin M, Kajihara I, Honda N, Sakai K, Masuguchi S, Fukushima S, Inoue Y, Ihn H.
  • Journal Title: Clin Exp Dermatol, Volume: 37 Pages: 34-39
  • Peer Reviewed
• [Journal Article] TGF-β-mediated down-regulation of microRNA-196a contributes to the constitutive up-regulated type I collagen expression in scleroderma dermal fibroblasts. (2012)
  • Author(s): Honda N, Jinnin M, Kajiwara I, Makino T, Makino K, Masuguchi S, Fukushima S, Okamoto Y, Hasegawa M, Fujimoto M, Ihn H.
  • Journal Title: J Immunol, Volume: 188 Pages: 3323-3331
  • Peer Reviewed
• [Journal Article] Increased serum levels of miR-1266 in patients with psoriasis vulgaris. (2012)
  • Author(s): Ichihara A, Jinnin M, Oyama R, Yamane K, Fujisawa A, Sakai K, Masuguchi S, Fukushima S, Maruo K, Ihn H.
  • Journal Title: Eur J Dermatol, Volume: 22 Pages: 68-71
  • Peer Reviewed
• [Journal Article] Impaired IL-17 signaling pathway contributes to the increased collagen expression in scleroderma fibroblasts. (2012)
  • Author(s): Nakajima T, Jinnin M, Honda N, Kajihara I, Makino T, Masuguchi S, Fukushima S, Okamoto Y, Hasegawa M, Fujimoto M, Ihn H.
  • Journal Title: J Immunol, Volume: 188 Pages: 3573-3583
  • Peer Reviewed
• [Journal Article] Photosensitivity and acute liver insufficiency in late-onset erythropoietic protoporphyria with a chromosome 18q abnormality. (2012)
  • Author(s): Oshikawa Y, Fukushima S, Miyake T, Kawaguchi T, Motomura K, Nakashima Y, Nakamura K, Jinnin M, Ihn H.
  • Journal Title: Case Rep Dermatol Volume: ４ Pages: 14-149
  • Peer Reviewed
• [Journal Article] Overexpression of hepatocyte growth factor receptor in scleroderma dermal fibroblasts is caused by autocrine transforming growth factor βsignaling. (2012)
  • Author(s): Kajihara I, Jinnin M, Makino T, Masuguchi S, Sakai K, Fukushima S, Maruo K, Inoue Y, Ihn H.
  • Journal Title: BioScience Trends, Volume: 6 Pages: 136-142
  • Peer Reviewed
• [Journal Article] microR-92a expression in the sera and dermal fibroblasts increases in patients with scleroderma. (2012)
  • Author(s): Sing T, Jinnin M, Yamane K, Honda N, Makino K, Kajihara I, Makino T, Sakai K, Mashuguchi S, Fukushima S, Ihn H.
  • Journal Title: Rheumatology, Volume: 51 Pages: 1550-1556
  • Peer Reviewed
• [Journal Article] Kinase family member 20A as is a novel melanoma-associated antigen. (2012)
  • Author(s): Yamashita J, Fukushima S, Jinnin M, Honda N, Makino K, Sakai K, Masuguchi S, Inoue Y, Ihn H.
  • Journal Title: Acta Derm Venereol, Volume: 92 Pages: 593-597
  • Peer Reviewed
• [Journal Article] CD163 expression is increased in the involved skin and sera of patients with systemic lupus erythematosus. (2012)
  • Author(s): Nakayama W, Jinnin M, Makino K, Kajihara I, Makino T, Fukushima S, Sakai k, Inoue Y, Ihn H.
  • Journal Title: Eur J Dermatol, Volume: 22 Pages: 512-517
  • Peer Reviewed
• [Journal Article] Serum angiopoietin-like protein 3 concentrations in rheumatic diserases. (2012)
  • Author(s): Hayashi Y, Jinnin M, Makino T, Kajihara I, Makino K, Honda N, Nakayama W, Inoue K, Fukushima S, Ihn H.
  • Journal Title: Eur J Dermatol, Volume: 22 Pages: 500-504
  • Peer Reviewed
• [Journal Article] Diagnostic and prognostic value of subcutaneous tissue biopsy in patients with cardiac amyloidosis. (2012)
  • Author(s): Takashio S, Izumiya Y, Jinnin M, Yamamuro M, Kojima S, Ihn H, Ogawa H.
  • Journal Title: Am J Cardiol, Volume: 110 Pages: 1507-1511
  • Peer Reviewed
• [Journal Article] Tsukushi controls the hair cycle by regulating TGF-β1 signaling. (2012)
  • Author(s): Niimori D, Kawano R, Felemban A, Niimori-Kita K, Tanaka H, Ihn H, Ohta K.
  • Journal Title: Dev Biol, Volume: 372 Pages: 81-87
  • Peer Reviewed
• [Journal Article] Case of blastic plasmaytoid dendritic cell neoplasm. (2012)
  • Author(s): Aoi J, Ogata A, Makino T, Sakai K, Masuguchi S, Fukushima S, Jinnin M, Inoue Y, Ihn H.
  • Journal Title: J Dermatol, Volume: 39 Pages: 1066-1067
  • Peer Reviewed
• [Journal Article] Serum concentration of angiogenin in patients with rheumatic diseases. (2012)
  • Author(s): Kuwahara A, Jinnin M, Makino T, Kajihara I, Makino K, Honda N, Nakayama W, Inoue K, Fukushima S, Ihn H.
  • Journal Title: BioScience Trends, Volume: 6 Pages: 229-233
  • Peer Reviewed
• [Presentation] Identification of disease-specific molecules in the skin of dermatomyositis and lupus erythematosus by proteomics analysis using LC-MS/MS. (2014)
  • Author(s): Nakamura K, Jinnin M, Fukushima S, Ihn H.
  • Organizer: 39 th Annual Meting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Osaka
  • Year and Date: 2014-12-12 – 2014-12-14
• [Presentation] Serum leptin receptor as a tumor marker of melanoma. (2014)
  • Author(s): Fukushima S, Mizutani H, Miyashita A, Yamashita J, Nakahara S, Jinnin M, Ihn H.
  • Organizer: 39 th Annual Meting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Osaka
  • Year and Date: 2014-12-12 – 2014-12-14
• [Presentation] Decreased IL-20 expression in scleroderma skin contributes to cutaneous fibrosis. (2014)
  • Author(s): Kudo H, Jinnin M, Ihn H.
  • Organizer: 39 th Annual Meting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Osaka
  • Year and Date: 2014-12-12 – 2014-12-14
• [Presentation] Search for the skin constancy maintenance factor using the proteomics method. . (2014)
  • Author(s): Niimori D, Niimori K, Ihn H.
  • Organizer: 39 th Annual Meting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: Osaka
  • Year and Date: 2014-12-12 – 2014-12-14
• [Presentation] Down-regulation of microRNA-196a in the sera and involved skin of localized scleroderma patients. (2014)
  • Author(s): Makino T, Jinnin M, Etoh M, Yamane K, Kajihara I, Makino K, Ichihara A, Igata T, Sakai K, Fukushima S, Ihn H.
  • Organizer: ACR
  • Place of Presentation: Boston
  • Year and Date: 2014-11-14 – 2014-11-19
• [Presentation] Potential use of polysaccharide as a skin care material for atopic dermatitis. (2014)
  • Author(s): Tanaka T, Tanida Y, Hayashi T, Motoyama K, Higashi T, Kaneko S, Ishitsuka Y, Irie T, Kaneko T, Okajima M, Ihn H, Arima H.
  • Organizer: International Federation of Societies of Cosmetic Chemists in Paris
  • Place of Presentation: Paris
  • Year and Date: 2014-10-27 – 2014-10-30
• [Presentation] Decreased IL-20 expression in scleroderma skin contributes to cutaneous fibrosis. (2014)
  • Author(s): Kudo H, Jinnin M, Ihn H.
  • Organizer: 2014 Montaguna Symposium on the biology of skin
  • Place of Presentation: Oregon U.S.A.
  • Year and Date: 2014-10-09 – 2014-10-13
• [Presentation] Immunothrapy with human iPS-cell derived myeloid cell lines producing type I interferons against metastatic melanoma. (2014)
  • Author(s): Miyashita A, Fukushima S, Nakahara S, Yamashita J, Senju S, Nishimura Y, Jinnin M, Ihn H.
  • Organizer: 44 th ESDR
  • Place of Presentation: Copenhagen
  • Year and Date: 2014-09-10 – 2014-09-13
• [Presentation] Serum levels of leptin receptor as a new tumor marker of malignant melanoma. (2014)
  • Author(s): Fukushima S, Mizutani H, Miyashita A, Yamashita J, Nakahara S, Jinnin M, Ihn H.
  • Organizer: 44 th ESDR
  • Place of Presentation: Copenhagen
  • Year and Date: 2014-09-10 – 2014-09-13
• [Presentation] Tsukushi controls the hair cycle by regulating TGF-β1 signaling. (2014)
  • Author(s): Niimori D, Fukushima S, Miyashita A, Ihn H.
  • Organizer: 44 th ESDR
  • Place of Presentation: Copenhagen
  • Year and Date: 2014-09-10 – 2014-09-13
• [Presentation] Sentinel node biopsy for non-melanoma skin cancers: A review of 88 cases at one institution. (2014)
  • Author(s): Fukushima S, Ihn H.
  • Organizer: 第11回日独皮膚科学会
  • Place of Presentation: ハイデルベルグ
  • Year and Date: 2014-06-11 – 2014-06-14
• [Presentation] Clinical significance of cobble stone appearance on the skin of patients with systemic sclerosis. (2014)
  • Author(s): Sawamura S, Kajihara I, Fukushima S, Ihn H.
  • Organizer: 第11回日独皮膚科学会
  • Place of Presentation: ハイデルベルグ
  • Year and Date: 2014-06-11 – 2014-06-14
• [Presentation] Successful treatment of skin fistulas in systemic sclerosis patients with the combination of topical negative pressure therapy and split-thickness skin grafting. (2014)
  • Author(s): Watanabe C, Kajihara I, Fukushima S, Ihn H.
  • Organizer: 第11回日独皮膚科学会
  • Place of Presentation: ハイデルベルグ
  • Year and Date: 2014-06-11 – 2014-06-14
• [Presentation] Clinical signaificance of CD169-positive lymph node macrophages in human malignant tumors. (2014)
  • Author(s): Ohnishi K, Saito Y, Komohara Y, Miyamoto Y, Fukushima S, Yamaguchi M, Baba H, Ihn H, Katabuchi H, Takeya M.
  • Organizer: 第50回米国癌治療学会議（ASCO2014）
  • Place of Presentation: シカゴ
  • Year and Date: 2014-05-30 – 2014-06-03
• [Presentation] 色素レーザーが有効であった毛細血管拡張症をを伴った全身性強皮症の1例 (2014)
  • Author(s): 牧野貴充、梶原一亨、神人正寿、尹 浩信
  • Organizer: 第37回皮膚脈管・膠原病研究会
  • Place of Presentation: 東京医科歯科大学M&Dタワー
• [Presentation] Effects of sarpogrelate for Raynaud’s phenomenon secondary to systemic sclerosis. (2014)
  • Author(s): Makino T, Jinnin M, Kajihara I, Makino K, Ihn H.
  • Organizer: 3 rd Systemic Sclerosis World Congress
  • Place of Presentation: Rome
• [Presentation] Scleroderma dermal fibroblasts overexpress vascular endothelial growth factor due to autocrine transforming growth factor-β signaling. (2014)
  • Author(s): Kajihara I, Jinnin M, Ihn H.
  • Organizer: 3 rd Systemic Sclerosis World Congress
  • Place of Presentation: Rome
• [Presentation] The effect of IL-17 on the extracellular matrix expression in dermal fibroblasts. (2013)
  • Author(s): Jinnin M, Ihn H.
  • Organizer: The American Society for Biochemistry and Molecular Biology
  • Place of Presentation: Boston (アメリカ）
• [Presentation] V beamが有効であった全身性強皮症に伴う毛細血管拡張症の1例 (2013)
  • Author(s): 牧野貴充、神人正寿、尹 浩信
  • Organizer: 第31回日本美容皮膚科学会
  • Place of Presentation: 神戸国際会議場（神戸）
• [Presentation] The levels of adiponectin are decreased in the skin and sera of diffuse cutaneous systemic sclerosis patients. (2012)
  • Author(s): Kubo Y, Fukushima S, Jinnin M, Makino T, Kajihara I, Ichihara A, Makino K, Ihn H.
  • Organizer: Annual European Congress of Rheumatology
  • Place of Presentation: Berlin(ドイツ）
• [Presentation] microRNA-150 down-regulation contributes to the constitutive type I collagen overexpression in scleroderma dermal fibroblasts via the induction of integrin β3. (2012)
  • Author(s): Honda N, JInnin M, Makino K, Makino T, Fukushima S, Inoue Y, Okamoto Y, Hasegawa M, Fujimoto M, Ihn H.
  • Organizer: 42 nd annual ESDR Meeting
  • Place of Presentation: Venice（イタリア）
• [Presentation] Dysregulated discoidin domain receptor 2-microRNA196a ‐mediated negative feedback against excess type I collagen expression in scleroderma dermal fibroblasts. (2012)
  • Author(s): Makino K, Jinnin M, Aoi J, Kajihara I, Makino T, Sakai K, Fukushima S, Inoue Y, Ihn H.
  • Organizer: American College of Rheumatology
  • Place of Presentation: Washington D.C.（アメリカ）
• [Presentation] Interleukin-23 signaling contributes to the increased collagen production in scleroderma fibroblasts. (2012)
  • Author(s): Nakayama W, Jinnin M, Fukushima S, Ihn H.
  • Organizer: The 37 th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: ロワジールホテル＆スパタワー那覇（Okinawa）
• [Presentation] microRNA-150 down-regulation contributes to the constitutive type I collagen overexpression in scleroderma dermal fibroblasts via the induction of integrinβ3. (2012)
  • Author(s): Honda N, Jinnin M, Makino K, Makino T, Fukushima S, Inoue Y, Okamoto Y, Hasegawa M, Fujimoto M, Ihn H.
  • Organizer: The 37 th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: ロワジールホテル＆スパタワー那覇（Okinawa）
• [Presentation] Excessive expression of type I collagen in systemic and localized scleroderma is caused by the down-regulation of microRNA let-7a. (2012)
  • Author(s): Makino K, Jinnin M, Yamane K, Eto M, Kusano T, Honda N, Kajihara I, Makino T, Sakai K, Masuguchi S, Fukushima S, Ihn H.
  • Organizer: The 37 th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: ロワジールホテル＆スパタワー那覇（Okinawa）
• [Presentation] Intravenous immunoglobulin treatment recovers the down-regulated levels of Th1 cytokines in the sera and skin of scleroderma patients. (2012)
  • Author(s): Kudo H, Jinnin M, Yamane K, Makino T, Kajihara I, Makino K, Honda N, Nakayama W, Fukushima S, Ihn H.
  • Organizer: The 37 th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: ロワジールホテル＆スパタワー那覇（Okinawa）
• [Presentation] Decreased adiponectin levels in the patients with diffuse cutaneous systemic sclerosis. (2012)
  • Author(s): Fukushima S, Jinnin M, Arakawa H, Makino T, Kajihara I, Makino K, Honda N, Inoue Y, Ihn H.
  • Organizer: The 37 th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: ロワジールホテル＆スパタワー那覇（Okinawa）
• [Book] 看護学大辞典 (2013)
  • Author(s): 尹 浩信
  • Total Pages: 2480
  • Publisher: メジカルフレンド社
• [Book] Monthly Book Derma No.202治りにくい皮膚病変 治療の実際 (2013)
  • Author(s): 尹 浩信
  • Total Pages: 80
  • Publisher: 全日本病院出版会
• [Book] 皮膚科臨床アセット12 新しい創傷治療のすべて 褥瘡、熱傷、皮膚潰瘍 (2013)
  • Author(s): 尹 浩信
  • Total Pages: 368
  • Publisher: 中山書店
• [Book] 創傷と痛み (2013)
  • Author(s): 尹 浩信
  • Total Pages: 168
  • Publisher: 金原出版
• [Book] 皮膚疾患最近の話題 (2013)
  • Author(s): 尹 浩信
  • Total Pages: 304
  • Publisher: 南江堂
• [Book] 一冊で分かる最新皮膚科治療 (2013)
  • Author(s): 尹 浩信
  • Total Pages: 328
  • Publisher: 文光堂