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Why the occurrence of eczema herpeticum caused by an extensive disseminated cutaneous infection with HSV-1 is associated with the exacerbation of atopic dermatitis lesion?

Research Project

Project/Area Number 24591664
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionKyorin University

Principal Investigator

TAKAHASHI RYO  杏林大学, 医学部, 助教 (00317091)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsアトピー性皮膚炎 / ヘルペスウィルス / カポジ水痘様発疹症 / 単球 / 制御性T細胞 / Treg / proinflammatory monocyte / Eczema Herpeticum / PILRα / CD16+単球
Outline of Final Research Achievements

It remains unknown why the occurrence of eczema herpeticum (EH) caused by an extensive disseminated cutaneous infection with HSV-1 is associated with the exacerbation of atopic dermatitis lesions. We investigated the frequencies, phenotype, and function of Tregs in the peripheral blood of atopic dermatitis with EH (ADEH) patients at onset and after clinical resolution. Tregs with the skin-homing phenotype and the activated/induced phenotype were expanded at onset and contracted upon resolution. Treg-suppressive capacity was retained in ADEH patients and, the expanded Tregs suppressed IFN-γ production from HSV-1-specific CD8+ T cells. The increased frequency of CD14dimCD16+ proinflammatory monocytes (pMOs) was also observed in the blood and EH skin lesions. Our co-culture study using Tregs and pMOs showed that the pMOs can promote the expansion of inducible Tregs. Tregs were detected frequently in the vicinity of HSV-expressing CD16+ monocytes in the EH lesions.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2014 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (5 results)

  • [Journal Article] Regulatory T Cells in Severe Drug Eruptions2014

    • Author(s)
      Shiohara T, Takahashi R, Ushigome Y, and Kano Y
    • Journal Title

      Current Immunology Reviews

      Volume: 10 Issue: 1 Pages: 41-50

    • DOI

      10.2174/1573395510666140616234723

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Crucial role of viral reactivation in the development of severe drug eruptions: a comprehensive review.2014

    • Author(s)
      Shiohara T, Ushigome Y, Kano Y, Takahashi R.
    • Journal Title

      Clin Rev Allergy Immunol

      Volume: - Issue: 2 Pages: 1-11

    • DOI

      10.1007/s12016-014-8421-3

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pathological role of regulatory T cells in the initiation and maintenance of eczema herpeticum lesions.2014

    • Author(s)
      Takahashi R, Sato Y, Kurata M, Yamazaki Y, Kimishima M, Shiohara T.
    • Journal Title

      J Immunol

      Volume: 192 Issue: 3 Pages: 969-978

    • DOI

      10.4049/jimmunol.1300102

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Patrolling monocytes sensing herpes simplex virus in severe drug eruption2014

    • Author(s)
      Yukiko Ushigome, Ryo Takahashi, Testuo Shiohara
    • Organizer
      The 6th drug hypersensitivity meeting (DHM6)
    • Place of Presentation
      Bern, Switzerland
    • Year and Date
      2014-04-09 – 2014-04-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Monocytes control Treg in severe drug eruption2014

    • Author(s)
      Tetsuo Shiohara, Ryo Takahashi, Yoko Kano, Yukiko Ushigome
    • Organizer
      The 6th drug hypersensitivity meeting (DHM6)
    • Place of Presentation
      Bern, Switzerland
    • Year and Date
      2014-04-09 – 2014-04-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] アトピー性皮膚炎患者におけるヘルペスウィルスの再活性化と制御性 T 細胞の動態2013

    • Author(s)
      高橋 良
    • Organizer
      第23回日本サイトメトリー学会 シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Suppressive CD14dimCD16+ monocytes contribute defective anti-viral immune responses in eczema herpeticum.2013

    • Author(s)
      Takahashi R and Shiohara T
    • Organizer
      International Investigative Dermatology 2013 meeting
    • Place of Presentation
      Edinburgh, Scotland
    • Related Report
      2013 Research-status Report 2012 Research-status Report
  • [Presentation] Increased expression of PILRα on patrolling monocytes sensing HSV is the mechanism by which HSV evades immune attack2012

    • Author(s)
      Takahashi R and Shiohara T
    • Organizer
      The International Investigative Dermatology 2012
    • Place of Presentation
      OKINAWA
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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