Conprehensive identification of important genes related to growing and maintaining the hair using knock down mice.

• Project/Area Number: 24591666
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Keio University
• Principal Investigator: KAZUNORI SHIBUYA 慶應義塾大学, 医学部, 助教 (90296723)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 毛髪 / 成長期 / ノックダウンマウス / miRNA

Outline of Final Research Achievements

Many people hold a trouble of hair becoming thin with aging.
Then, the experiment which searches for the gene which maintains and grows up hair using a genetically engineered mouse (knockdown-mouse) was conducted. As a result, the expected phenotype which has change in hair was not observed, although it succeeded in producing a genetically engineered mouse.