Contribution of mast cell functions to the pathogenesis of allergic inflammatory diseases and role of Notch signaling in regulating mast cell functions
Project/Area Number |
24591667
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Dermatology
|
Research Institution | Juntendo University |
Principal Investigator |
NAKANO Nobuhiro 順天堂大学, 医学(系)研究科(研究院), 助教 (30420839)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | アレルギー / マスト細胞 / Notchシグナル / サイトカイン / Notch |
Outline of Final Research Achievements |
Cytokines produced by mast cells play an important role in the pathogenesis and exacerbation of allergic inflammatory diseases. This study revealed that signaling through cell surface Notch receptors enhances the production of Th2 and inflammatory cytokines by mast cells through direct and indirect mechanisms. Furthermore, results from this study suggest that Notch signaling contributes to the maturation of mucosal-type mast cells, and thus I have analyzed the molecular mechanisms of Notch-induced mast cell maturation.
|
Report
(4 results)
Research Products
(17 results)
-
[Journal Article] Notch signaling enhances FceRI-mediated cytokine production by mast cells through direct and indirect mechanisms2015
Author(s)
Nakano, N., Nishiyama, C., Yagita, H., Hara, M., Motomura, Y., Kubo, M., Okumura, K., and Ogawa, H
-
Journal Title
J. Immunol
Volume: 194(9)
Issue: 9
Pages: 4535-44
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Critical Roles for PU.1, GATA1, and GATA2 in the Expression of Human FcεRI on Mast Cells: PU.1 and GATA1 Transactivate FCER1A, and GATA2 Transactivates FCER1A and MS4A22014
Author(s)
Inage E, Kasakura K, Yashiro T, Suzuki R, Baba Y, Nakano N, Hara M, Tanabe A, Oboki K, Matsumoto K, Saito H, Niyonsaba F, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T, and Nishiyama C
-
Journal Title
Journal of Immunology
Volume: 192
Issue: 8
Pages: 3936-46
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Circadian regulation of allergic reactions by the mast cell clock in mice.2014
Author(s)
Nakamura Y, Nakano N, Ishimaru K, Hara M, Ikegami T, Tahara Y, Katoh R, Ogawa H, Okumura K, Shibata S, Nishiyama C, Nakao A
-
Journal Title
J Allergy Clin Immunol
Volume: 133(2)
Issue: 2
Pages: 568-575
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-