| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Schizophrenia is a severe mental disorder of which molecular mechanisms must be clarified. Previously, altered mRNA expression of adrenomedullin (ADM) was suggested to contribute to the pathophysiology by some studies including that of monozygotic twins discordant for the illness. In this study, all of the coding regions of ADM gene in 474 cases and 475 controls were re-sequenced, and I assessed the contribution of the rare variants to the illness. I further examined the difference of DNA methylation status in two pairs of the monozygotic discordant twins by using Human Methylation450 array. The rare variants was observed in only one control but not in patients, which did not show the contribution of the rare coding variants of ADM to the illness. The differences of the DNA methylation status for the 19 sites on the array among the twins were not observed. Further studies are needed to clarify the mechanism affecting the altered mRNA expression of ADM in schizophrenia.
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