| Project/Area Number |
24591678
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Katsuaki 浜松医科大学, 医学部, 准教授 (00285040)
SAKAHARA Haruumi 浜松医科大学, 医学部, 教授 (10187031)
IWATA Yasuhide 浜松医科大学, 医学部附属病院, 講師 (10285025)
OUHI Yasuomi 浜松医科大学, メディカルフォトニクス研究センター, 教授 (40436978)
NAKAMURA Kazuhiko 弘前大学, 医学(系)研究科(研究院), 教授 (80263911)
山下 修平 浜松医科大学, 医学部附属病院, 講師 (90402312)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ADHD / PET / dopamine / microglia / D1 / ミクログリア |
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| Outline of Final Research Achievements |
Age and IQ are matched between ADHD group and healthy comparison group. PET ROI analysis revealed no significant differences of BPs of SCH23390 (DA1 receptor density) and PK11195 (microglial activation) in the brain areas examined; midbrain, cerebellum, thalamus, caudate nucleus, nucleus accumbens, orbitofrontal cortex, medialfrontal cortex, dorsolateral prefrontal cortex, and occipital cortex, between two groups. Eight subscales of CAARS are higher in ADHD group compared to healthy comparison group. RVP-A' in CANTAB-ADHD is lower in ADHD group compared to healthy comparison group, indicating lower ability of sustained attention in ADHD group. No other differences of outcome measures in CANTAB-ADHD between two groups were found.
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