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Integrated research on brain network dysfunctions and pathogenic factors of panic disorder

Research Project

Project/Area Number 24591679
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionMie University

Principal Investigator

Tanii Hisashi  三重大学, 医学系研究科, 准教授 (40346200)

Co-Investigator(Kenkyū-buntansha) 城山 隆  三重大学, 医学部附属病院, 講師 (00252354)
Research Collaborator Konishi Yoshiaki  
Tanahashi Shunsuke  
Takase Shinichi  
Project Period (FY) 2012-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsパニック症 / 遺伝子多型 / 拡散テンソル画像 / ライフイベント / パニック障害
Outline of Final Research Achievements

Using the 3T MRI apparatus, we carried out diffusion tensor imaging of panic disorder patients and healthy control subjects. We will focus on the thalamus radiation, the uncinate fasciculus, the inferior fronto-occipital fasciculus, the left anterior cingulate gyrus and right posterior cingulate gyrus, which comprise the input/output system of the frontal lobe. We examined representative genetic polymorphisms (COMT Val158Met polymorphism, BDNFval66met polymorphism, Sigma 1 receptor related gene etc), Secondly, factor analysis and principal component analysis were conducted on the results of NEO - PI - R, TCI, STAI and GHQ 12 on the state of anxiety for healthy control volunteers and panic disorder patients. I studied the involvement of genetic factors upon life events and symptoms at panic attack.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (40 results)

All 2017 2016 2015 2014 2013 2012 Other

All Journal Article (23 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 21 results,  Open Access: 5 results,  Acknowledgement Compliant: 6 results) Presentation (11 results) (of which Invited: 4 results) Book (6 results)

  • [Journal Article] A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder2017

    • Author(s)
      Ikeda M, Shimasaki A, Takahashi A,et al.
    • Journal Title

      Mol Psychiatry

      Volume: 23 Issue: 3 Pages: 639

    • DOI

      10.1038/mp.2016.259

    • NAID

      120006980540

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Epigenome-wide association study of DNA methylation in panic disorder2017

    • Author(s)
      Shimada-Sugimoto, M., T. Otowa, T. Miyagawa, T. Umekage, Y. Kawamura, M. Bundo, K. Iwamoto, M. Tochigi, K. Kasai, H. Kaiya, H. Tanii, Y. Okazaki, K. Tokunaga and T. Sasaki
    • Journal Title

      Clinical Epigenetics

      Volume: 9 Issue: 1 Pages: 6-6

    • DOI

      10.1186/s13148-016-0307-1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of polygenic risks for narcolepsy and essential hypersomnia2016

    • Author(s)
      Yamasaki M, Miyagawa T, Toyoda H, Khor SS, Liu X, Kuwabara H, Kano Y, Shimada T, Sugiyama T, Nishida H, Sugaya N, Tochigi M, Otowa T, Okazaki Y, Kaiya H, Kawamura Y, Miyashita A, Kuwano R, Kasai K, Tanii H, Sasaki T, Honda Y, Honda M, Tokunaga K
    • Journal Title

      Journal of Human Genetics

      Volume: 61(10) Issue: 10 Pages: 873-878

    • DOI

      10.1038/jhg.2016.65

    • NAID

      40020966185

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population.2016

    • Author(s)
      Shimada-Sugimoto M, Otowa T, Miyagawa T, Khor S-S, Omae Y, Toyo-oka L, Sugaya N, Kawamura Y, Umekage T, Miyashita A, Kuwano R, Kaiya H, Kasai K, Tanii H, Okazaki Y, Tokunaga K, Sasaki T
    • Journal Title

      Human Genome Variation

      Volume: 3 Issue: 1 Pages: 16001-16001

    • DOI

      10.1038/hgv.2016.1

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Auditory change-related cerebral responses and personality traits2016

    • Author(s)
      Tanahashi M., Motomura E., Inui K. et al.
    • Journal Title

      Neuroscience Research

      Volume: 103 Pages: 34-39

    • DOI

      10.1016/j.neures.2015.08.005

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Candidate Genes in Panic Disorder: Meta-Analyses of 23 Common Variants in Major Anxiogenic Pathways.2015

    • Author(s)
      Howe AS, Buttenschon H, Bani-Fatemi A, Maron E, Otowa T, Erhardt A, Binder EB, Gregersen N, Domschke K, Reif A, Shlik J, Koks S, Kawamura Y, Miyashita A, Kuwano R, Tokunaga K, Tanii H, Sasaki T, Smoller JW, De Luca1 V
    • Journal Title

      Molecular Psychiatry

      Volume: 20 Issue: 5 Pages: 1-15

    • DOI

      10.1038/mp.2015.138

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Immune-related pathways including HLA-DRB1(*)13:02 are associated with panic disorder.2015

    • Author(s)
      Shimada-Sugimoto M ほか
    • Journal Title

      Brain Behav Immun

      Volume: Epub Pages: 96-103

    • DOI

      10.1016/j.bbi.2015.01.002

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anger tendency may be associated with duration of illness in panic disorder.2015

    • Author(s)
      Sugaya N, Yoshida E, Yasuda S, Tochigi M, Takei K, Otowa T, Umekage T, Konishi Y, Sakano Y, Nomura S, Okazaki Y, Kaiya H, Tanii H, Sasaki T,
    • Journal Title

      BioPsychoSocial Medicine

      Volume: 9 Issue: 1 Pages: 1-6

    • DOI

      10.1186/s13030-015-0035-3

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dysfunction of ventrolateral prefrontal cortex underlying social anxiety disorder: a multi-channel NIRS study2015

    • Author(s)
      Yokoyama C, Kaiya H, Kumano H, Kinou M, Umekage T, Yasuda S, Takei K, Nishikawa, M, Sasaki T, Nishimura Y, Hara N, Inoue K, Kaneko Y, Suzuki S, Tanii H, Okada M, Okazaki Y
    • Journal Title

      NeuroImage: Clinical

      Volume: 8 Pages: 455-461

    • DOI

      10.1016/j.nicl.2015.05.011

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] パニック症(パニック障害)における脳画像研究-NIRSを中心に-. 第14回日本認知療法学会シンポジウム「脳画像研究によるうつ、不安、心身症の病態解明」2015

    • Author(s)
      谷井久志
    • Journal Title

      認知療法研究

      Volume: 8(2) Pages: 149-152

    • Related Report
      2015 Research-status Report
  • [Journal Article] 社交不安症の脳機能イメージング研究2015

    • Author(s)
      横山知加, 貝谷久宣, 谷井久志, 熊野宏昭
    • Journal Title

      不安症研究

      Volume: 7(1) Pages: 52-63

    • Related Report
      2015 Research-status Report
  • [Journal Article] Gender-specific association between the COMT Val158Met polymorphism and openness to experience in panic disorder patients.2014

    • Author(s)
      Konishi Y, Tanii H, Otowa T, Sasaki T, Motomura E, Fujita A, Umekage T, Tochigi M, Kaiya H, Okazaki Y, Okada M
    • Journal Title

      Neuropsychobiology

      Volume: 69 Issue: 3 Pages: 165-174

    • DOI

      10.1159/000360737

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] he association of BDNF Val66Met polymorphism with trait anxiety in panic disorder.2014

    • Author(s)
      Konishi Y, Tanii H, Otowa T, Sasaki T, Kaiya H, Okada M, Okazaki Y
    • Journal Title

      The Journal of Neuropsychiatry and Clinical Neurosciences

      Volume: 26 Pages: 344-351

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] パニック障害における発症年齢と人格特性の関連性についての検討2014

    • Author(s)
      小西喜昭, 谷井久志
    • Journal Title

      不安症研究

      Volume: 6 Pages: 25-33

    • NAID

      130004700822

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Genexgenexgender interaction of BDNF and COMT genotypes associated with panic disorder2014

    • Author(s)
      Konishi, Y., Tanii, H., Otowa, T., Sasaki, T., Tochigi, M., Umekage, T., Motomura, E., Shiroyama, T., Kaiya, H., Okazaki, Y., Okada, M.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 51C Pages: 119-125

    • DOI

      10.1016/j.pnpbp.2014.01.020

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prevalence of bipolar disorder in panic disorder patients in the Japanese population.2013

    • Author(s)
      Sugaya N,Otowa T 7/18, Umekage T 9/18, Sasaki T17/18
    • Journal Title

      J Affect Disord.

      Volume: 147(1-3) Issue: 1-3 Pages: 411-5

    • DOI

      10.1016/j.jad.2012.10.014

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia.2013

    • Author(s)
      Khor SS, Miyagawa T, Toyoda H, Yamasaki M, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Lin L, Faraco J, Rico T, Honda Y, Honda M, Mignot E, Tokunaga K.
    • Journal Title

      PeerJ

      Volume: 1 Pages: 66-80

    • DOI

      10.7717/peerj.66

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] .Effects of acute nicotine on prepulse inhibition of auditory change-related cortical responses.2013

    • Author(s)
      Kodaira M, Tsuruhara A, Motomura E, Tanii H, Inui K, Kakigi R.
    • Journal Title

      Behav Brain Res.

      Volume: 256 Pages: 27-35

    • DOI

      10.1016/j.bbr.2013.07.045

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Irritable bowel syndrome, its cognition, anxiety sensitivity, and anticipatory anxiety in panic disorder patients.2013

    • Author(s)
      Sugaya N, Yoshida E, Yasuda S, Tochigi M, Takei K, Ohtani T, Otowa T, Minato T, Umekage T, Sakano Y, Chen J, Shimada H, Nomura S, Okazaki Y, Kaiya H, Tanii H, Sasaki T
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 67(6) Issue: 6 Pages: 397-404

    • DOI

      10.1111/pcn.12069

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The development of agoraphobia is associated with the symptoms and location of a patient's first panic attack.2012

    • Author(s)
      Hara N, Nishimura Y, Yokoyama C, Inoue K, Nishida A, Tanii H, Okada M, Kaiya H, Okazaki Y
    • Journal Title

      BioPsychoSocial Medicine

      Volume: 6(1) Pages: 12-12

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population2012

    • Author(s)
      Okada Y, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Kawaguchi T, Stahl EA, Kurreeman FA, Nishida N, Ohmiya H, Myouzen K, Takahashi M, Sawada T, Nishioka Y, Yukioka M, Matsubara T, Wakitani S, Teshima R, Tohma S, Takasugi K, Shimada K, Murasawa A, Honjo S, Matsuo K, Tanaka H, Tajima K, Suzuki T, Iwamoto T, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Gregersen PK, Padyukov L, Worthington J, Siminovitch KA, Lathrop M, Taniguchi A, Takahashi A, Tokunaga K, Kubo M, Nakamura Y, Kamatani N, Mimori T, Plenge RM, Yamanaka H, Momohara S, Yamada R, Matsuda F, Yamamoto K.
    • Journal Title

      Nat Genet.

      Volume: (in press) Issue: 5 Pages: 511-6

    • DOI

      10.1038/ng.2231

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Meta-analysis of genome-wide association studies for panic disorder in Japanese population.2012

    • Author(s)
      Otowa T 1/32, Umekage T 17/32, Sasaki T 32/32
    • Journal Title

      Translational Psychiatry

      Volume: 13;2 Issue: 11 Pages: 1-8

    • DOI

      10.1038/tp.2012.89

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Replication and meta-analysis of TMEM132D gene variants in panic disorder,2012

    • Author(s)
      Erhardt A, Akula N, Schumacher J, et al.
    • Journal Title

      Translational Psychiatry

      Volume: 2 Issue: 9 Pages: e156-e156

    • DOI

      10.1038/tp.2012.85

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] パニック症における併存症とセロトニントランスポーター遺伝子多型の関連について2016

    • Author(s)
      棚橋俊介、谷井久志、林隆昌、小西喜昭、岡田元宏、貝谷久宣、音羽健司、佐々木司、岡崎祐士
    • Organizer
      第38回日本生物学的精神医学会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 嚥下障害患者におけるITCZ内用液の粘度調節により服薬アドヒアランスを高めた一症例2015

    • Author(s)
      小西喜昭、谷井久志、森章哉、黒川公恵 、下地康雄、中谷理恵 、森川静香 、山川卓哉
    • Organizer
      第25回日本医療薬学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Research-status Report
  • [Presentation] パニック症におけるライフイベントとSigma1遺伝子多型の関与についての検討2015

    • Author(s)
      谷井久志、前田和輝、小西喜昭、棚橋俊介、岡田元宏、貝谷久宣、音羽健司、佐々木司、岡崎祐士
    • Organizer
      第37回日本生物学的精神医学会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Research-status Report
  • [Presentation] パニック症(パニック障害)とNIRSをはじめとした脳画像研究2014

    • Author(s)
      谷井久志
    • Organizer
      日本認知療法学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-09-14
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] The association between brain-derived neurotrophic factor gene polymorphism and anxiety-related traits in women with panic disorder

    • Author(s)
      小西喜昭、谷井久志、岡田元宏 城山隆 元村英史、音羽健司、佐々木司、貝谷久宣、岡崎祐士 栃木衛、梅影正
    • Organizer
      第11回世界生物学的精神医学会国際会議・第35回日本生物学的精神医学会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] 不安障害や精神疾患の遺伝子解析研究の発展性や限界

    • Author(s)
      谷井久志
    • Organizer
      第6回日本不安障害学会学術大会
    • Place of Presentation
      東京大学 山上会館・伊藤謝恩ホール
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] パニック障害のBDNFとCOMTと性別における遺伝子性別相互作用に関する検討

    • Author(s)
      小西喜昭、谷井久志、岡田元宏 城山隆 元村英史、音羽健司、佐々木司、貝谷久宣、岡崎祐士 栃木衛、梅影正
    • Organizer
      第6回日本不安障害学会学術大会
    • Place of Presentation
      東京大学 山上会館・伊藤謝恩ホール
    • Related Report
      2013 Research-status Report
  • [Presentation] パニック障害のCOMTVal158Met遺伝子多型と性差の相互作用と開放性について

    • Author(s)
      谷井久志、小西喜昭、岡田元宏 城山隆 元村英史、音羽健司、佐々木司、貝谷久宣、岡崎祐士 栃木衛、梅影正
    • Organizer
      第6回日本不安障害学会学術大会
    • Place of Presentation
      東京大学 山上会館・伊藤謝恩ホール
    • Related Report
      2013 Research-status Report
  • [Presentation] パニック障害と双極性障害の併存について Clinical and Epidemiological Study on Panic Disorder and Bipolar Disorders

    • Author(s)
      谷井久志
    • Organizer
      第14回八ケ岳シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] パニック障害の遺伝子研究

    • Author(s)
      谷井久志
    • Organizer
      第15回和風会研究会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] パニック障害の女性における脳由来神経栄養因子(BDNF)遺伝子多型と不安感受性についての検討

    • Author(s)
      小西喜昭、谷井久志、岡田元宏他
    • Organizer
      第4回日本不安障害学会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Book] 日本臨床75巻6月号 別冊精神科症候群II(第2版)2017

    • Author(s)
      谷井久志
    • Publisher
      日本臨床社
    • Related Report
      2016 Annual Research Report
  • [Book] 精神科研修ノート第2版2016

    • Author(s)
      谷井久志
    • Total Pages
      640
    • Publisher
      診断と治療社
    • Related Report
      2016 Annual Research Report
  • [Book] パニック症. 「こころの科学増刊 不安症の事典」(貝谷久宣・佐々木司・清水栄司編著)2015

    • Author(s)
      谷井久志
    • Total Pages
      168
    • Publisher
      日本評論社
    • Related Report
      2015 Research-status Report
  • [Book] 女性のうつ病に併存する精神疾患 - 不安症を中心に. 「女性のうつ病―ライフステージからみた理解と対応」 (松島英介・仙波純一編著)2015

    • Author(s)
      谷井久志
    • Total Pages
      300
    • Publisher
      メディカル・サイエンス・インターナショナル
    • Related Report
      2015 Research-status Report
  • [Book] 『こころの科学増刊 不安症の事典』 PART 2 不安症の診断・治療 第2章 パニック症2014

    • Author(s)
      谷井久志
    • Total Pages
      4
    • Publisher
      日本評論社
    • Related Report
      2014 Research-status Report
  • [Book] 「パニック障害における双極性障害」 『不安障害と双極性障害』(共著)2013

    • Author(s)
      谷井久志
    • Total Pages
      13
    • Publisher
      日本評論社
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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