| Project/Area Number |
24591683
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nagasaki University |
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Principal Investigator |
OZAWA Hiroki 長崎大学, 医歯薬学総合研究科(医学系), 教授 (50260766)
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| Co-Investigator(Kenkyū-buntansha) |
KINOSHITA Hirohisa 長崎大学, 病院(医学系), 講師 (10380883)
KUROTAKI Naohiro 長崎大学, 医歯薬学総合研究科(医学系), 講師 (20423634)
IMAMURA Akira 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (40325642)
TATSUMI Rie 長崎大学, 医歯薬学総合研究科(医学系), 助教 (40584727)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 神経幹細胞 / 気分障害 / 培養細胞 / 神経新生 / 変性疾患 / メチルフェデート / ADHD / オメガ３脂肪酸 / 変成疾患 / ＥＰＡ / ＤＨＡ / オメガ3脂肪酸 / 難治化 / 抗うつ薬 |
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| Outline of Final Research Achievements |
The psychostimulant methylphenidate (MPH) is the first choice of drug treatment in Attention-Deficit/Hyperactivity Disorder (ADHD) including depression state. We examined the influences of an acute treatment with MPH on the differentiation and proliferation of murine neural stem cells (mNSC).We found that MPH enhanced neuronal differentiation and inhibited neural proliferation. Moreover, ADHDs with depressive state were lower in ω3 fatty acid and modified electroconvulsive therapy for the treatment of refractory schizophrenia-like psychosis associated with Huntington’s disease. Taken together, these results suggest NSC is a key element for a pathophysiology of neuropsychiatric disorders including mood disorders.
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