| Project/Area Number |
24591684
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Ryuichiro 宮崎大学, 安全衛生保健センター, 教授 (90336298)
ABE Hiroshi 宮崎大学, 医学部, 講師 (20344848)
NISHIMORI Toshikazu 宮崎大学, 医学部, 研究員 (20112211)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | パーキンソン病 / 神経移植 / 転写調節因子 / ドパミン / 行動薬理学 |
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| Outline of Final Research Achievements |
A study was carried out to examine the effects of repeated L-DOPA treatment on the distribution of the immediate-early gene (IEG) proteins (FosB, c-Fos, and Zif268) in forebrain regions in a unilateral 6-hydroxydopamine (6-OHDA) rat model of Parkinson’s disease with or without intrastriatal grafts of fetal ventral mesencephalon. During a course of repeated L-DOPA treatment, rats with a 6-OHDA lesion developed abnormal involuntary movements. In summary, differential expression of three IEG proteins was observed in the forebrain regions during a course of repeated L-DOPA treatment of 6-OHDA-treated hemiparkinsonian rats.
The other goal of this study was to investigate the effect of intrastriatal grafts of fetal ventral mesencephalon (VM) on the withdrawal response in 6-OHDA rats. The present results suggest that the intrastriatal grafts of fetal VM may relieve pain sensation induced by mechanical stimulation in 6-OHDA rats.
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