Differential and early diagnosis of dementia using distinct plasma biomarkers
| Project/Area Number |
24591686
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
SOHMA Hitoshi 札幌医科大学, 医療人育成センター, 教授 (70226702)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 血漿バイオマーカー、 / アネキシンA5 / MFG-E8 / アルツハイマー病 / レビー小体型認知症 / 軽度認知障害 / バイオマーカー / 認知症 / 高齢者鬱 / 血漿バイオマーカー / 血液 / モデル動物 |
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| Outline of Final Research Achievements |
We investigated plasma biomarker for subsidiary role on diagnosis of dementia. Plasma samples were obtained from 150 AD patients, 50 DLB patients, 14 mild cognitive impairment (MCI) patients and 279 community-dwelling healthy elderly individuals (control). We have previously identified annexin A5 and MFG-E8 as potential plasma biomarkers. The plasma level of MFG-E8 tended to be elevated in AD patients than in control. The plasma level of annexin A5 was significantly higher in both AD and DLB patients than in control. This suggests that annexin A5 is a common marker for both AD and DLB, which implies the probability of a pathological aspect of overlapping of AD and DLB. Interestingly, the level of plasma annexin A5 was also significantly higher in MCI patients than in control. This suggests that annexin A5 was elevated an early stage of the onset of AD and/or DLB and might contribute to early diagnosis of the disease.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Effects of atelocollagen on neural stem cell function and its migrating capacity into brain in psychiatric disease model2013
Author(s)
Yoshinaga T, Hashimoto E, Ukai W, Ishii T, Shirasaka T, Kigawa Y, Tateno M, Kaneta H, Watanabe K, Igarashi T, obayashi S, Sohma H, Kato T, Saito T.
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Journal Title
Journal of Neural Transmission
Volume: 120
Pages: 1491-1498
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of atelocollagen on neural stem cell function and its migrating capacity into brain in psychiatric disease model.2013
Author(s)
Yoshinaga T, Hashimoto E, Ukai W, Ishii T, Shirasaka T, Kigawa Y, Tateno M, Kaneta H, Watanabe K, Igarashi T, Kobayashi S, Sohma H, Kato T, Saito T
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Journal Title
J. Neural Transm.
Volume: 120
Related Report
Peer Reviewed
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[Presentation] Sohma H, Imai S, Matsuki K, Takei N, Honda H, Utsumi K, Hashimoto E, Saito T, Kokai Y. Investigation of annexin A5 as a biomarker for Alzheimer's disease and Dementia with Lewy bodies.2012
Author(s)
Sohma H, Imai S, Matsuki K, Takei N, Honda H, Utsumi K, Hashimoto E, Saito T, Kokai Y
Organizer
3rd International Conference on Biomarkers & Clinical Research
Place of Presentation
Las Vegas, U.S.A.
Related Report
Invited
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