To realize an etiology of schizophrenia and develop preventable methods of schizophrenia through the mechanism of QT interval prolongation

• Project/Area Number: 24591688
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Dokkyo Medical University
• Principal Investigator: FUJII Kumiko 獨協医科大学, 医学部, 講師 (70314151)
• Co-Investigator(Kenkyū-buntansha): OZEKI Yuji 獨協医科大学, 精神神経医学講座, 准教授 (90303768)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 統合失調症 / QT間隔

Outline of Final Research Achievements

The patients with schizophrenia not receiving antipsychotic treatment had longer QT intervals than the healthy volunteers. The result was published in PLOS ONE. Because KCNH2, NRG1,AKAP9977 and AKAP9978 are the genes which could have relationship with both etiology and QT interval of schizophrenia, mRNA expressions of the genes are measured in patients with schizophrenia and normal controls and the mRNA expressions were compared with QT intervals in patients with schizophrenia. The results were that AKAP9977 mRNA expression was decreased but NRG1 mRNA expression was increased in patients with schizophrenia. There was a relationship between NRG1 and heart rates but no other relationships were found between mRNA expression levels and QT intervals or heart rates.

Research Products

• [Journal Article] QT is longer in drug-free patients with schizophrenia compared with age-matched healthy subjects (2014)
  • Author(s): Kumiko Fujii, Yuji Ozeki, Hiroaki Okayasu, Yumiko Takano, Takahiro Shinozaki, Hiroaki Hori, Masami Orui, Minoru Horie, Hiroshi Kunugi, Kazutaka Shimoda
  • Journal Title: PLOS ONE Volume: 9 Issue: 6 Pages: e98555-e98555
  • DOI: 10.1371/journal.pone.0098555
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Simultaneous determination of NG-monomethyl-L-arginine, NG,NG-dimethyl- L-arginine, and NG,NG’-dimethyl- L-arginine , and L-arginine using monolithic silica disk-packed spin columns and a monolithic silica column (2014)
  • Author(s): S. Nonaka, M. Sekine, M. Tsunoda, Y. Ozeki, K. Fujii, K. Akiyama, K. Shimoda, T. Furuchi, M. Katane, Y. Saitoh, and H. Homma:
  • Journal Title: J. Sep. Sci. Volume: 37 Issue: 16 Pages: 2087-2094
  • DOI: 10.1002/jssc.201400240
  • Peer Reviewed / Open Access
• [Journal Article] QT is Longer in Drug-Free Patients with Schizophrenia Compared with Age-Matched Healthy Subjects (2014)
  • Author(s): Kumiko Fujii, Yuji Ozeki, Hiroaki Okayasu, Yumiko Takano, Takahiro Shinozaki, Hiroaki Hori, Masami Orui, Minoru Horie, Hiroshi Kunugi, Kazutaka Shimoda
  • Journal Title: PLOS ONE Volume: in press
  • Peer Reviewed
• [Presentation] 統合失調症とQT間隔の両方に関連する可能性のある遺伝子の血液中mRNA発現量の検討とQT間隔との比較 (2014)
  • Author(s): 藤井 久彌子、尾関 祐二、岡安 寛明、髙野 有美子、篠崎隆央、秋山一文、下田 和孝
  • Organizer: 第36回日本生物学的精神医学会
  • Place of Presentation: 奈良、日本
  • Year and Date: 2014-09-29 – 2014-10-01
• [Presentation] Evaluation of QTc intervals in drug- naïve patients with schizophrenia (2013)
  • Author(s): Kumiko Fujii, Yuji Ozeki, Hiroaki Okayasu, Yumiko Okuri, Hiroaki Hori, Masami Orui, Minoru Horie, Hiroshi Kunugi, Kazutaka Shimoda
  • Organizer: 14th International Congress on Schizophrenia Research
  • Place of Presentation: Florida, USA
• [Presentation] Evaluation of QTc intervals in drug- naive patients with schizophrenia (2013)
  • Author(s): Kumiko Fujii, Yuji Ozeki, Hiroaki Okayasu, Yumiko Takano, Hiroaki Hori, Masami Orui, Minoru Horie, Hiroshi Kunugi, Kazutaka Shimoda
  • Organizer: International Congress on Schizophrenia Research
  • Place of Presentation: Orlando, USA