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Generation of iPS cells from dental pulp of autism patients

Research Project

Project/Area Number 24591693
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionInstitute for Developmental Research, Aichi Human Service Center

Principal Investigator

Nakayama Atsuo  愛知県心身障害者コロニー発達障害研究所, 発生障害学部, 部長 (50227964)

Co-Investigator(Kenkyū-buntansha) FUKADA Masahide  愛知県心身障害者コロニー発達障害研究所, 発生障害学部, 研究員 (80414019)
Research Collaborator IIO Akio  
MATSUKI Tohru  
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords自閉症 / iPS細胞 / 神経細胞 / 研究リソース / 歯髄細胞 / 神経細胞分化 / ニューロリギン4X / 発達障害 / 歯髄幹細胞 / 自閉症スペクトラム障害
Outline of Final Research Achievements

In order to establish research materials useful for revealing neuronal abnormalities in autistic patient, we have introduced re-programing agents into dental pulp stem cells obtained from 10 autistic patients. During the period, we could established two induced pluripotent stem (iPS) cell clones derived from autistic patients. These iPS cell clones can differentiate into the neuronal lineage expressing several markers for neuronal precursor cells. At this differentiated stage, however, we could not find clear abnormalities in morphology and proliferative potential compared with neuronal precursor cells differentiated from control iPS cells. In spite of the results, we emphasize that these iPS clones derived from autistic patients are useful materials to reveal detailed neuronal abnormalities of autism in future in vitro studies.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (11 results)

All 2016 2015 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 2 results) Presentation (5 results) (of which Invited: 1 results)

  • [Journal Article] Characterisation of novel RUNX2 mutation with alanine tract expansion from Japanese cleidocranial dysplasia patient2016

    • Author(s)
      Shibata A., Machida J., Yamaguchi S., Kimura M., Tatematsu T., Miyachi H, Matsushita M., Kitoho H., Ishiguro N., Nakayama A., Higashi Y., Shimozato K., Tokita Y
    • Journal Title

      Mutagenesis

      Volume: 31 Pages: 61-67

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An aberrant splice acceptor site due to a novel intronic nucleotide substitution in MSX1 gene is the cause of congenital tooth agenesis in a Japanese family2015

    • Author(s)
      Tatematsu T., Kimura M., Nakashima M., Machida J., Yamaguchi S., Shibata A., Goto H., Nakayama A., Higashi Y., Miyachi H., Shimozato K., Matsumoto N., Tokita Y
    • Journal Title

      PLoS One

      Volume: 10 Pages: 1-6

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel nonsense mutation in MSX1 in familial nonsyndromic oligodentia: subcellular loalization and role of homeodomain/MH4.2014

    • Author(s)
      Kimura M., Machida J., Yamaguchi S., Shibata A., Tatematsu T., Miyachi H., Jezewski PA., Nakayama A., Higashi Y., Shimozato K., Tokita Y.
    • Journal Title

      Eur J Oral Sci

      Volume: 122(1) Issue: 1 Pages: 15-20

    • DOI

      10.1111/eos.12105

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] DDX6 post-transcriptionally down-regulates miR-143/145 expression through host gene NCR143/145 in cancer cells.2013

    • Author(s)
      Iio A.,Takagi T., Miki K., Naoe T., Nakayama A., and Akao Y.
    • Journal Title

      Biochim Biophys Acta

      Volume: 1829(10) Pages: 1102-10

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identical sets of methylated and nonmethylated genes in Ciona intestinalis sperm and muscle cells.2013

    • Author(s)
      Suzuki MM., YOshinari A., Obara M., Takuno S., Shigenobu S., Sasakura Y., Kerr AR., Webb S., Bird A., Nakayama A.
    • Journal Title

      Epigenetics Chromatin

      Volume: 6(1) Pages: 38-44

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Loss of deacetylation activity of hdac6 affects emotional behavior in mice2012

    • Author(s)
      Masahide Fukada
    • Journal Title

      PLoS One

      Volume: 7 Issue: 2 Pages: e30924-e30924

    • DOI

      10.1371/journal.pone.0030924

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 自閉症の生物学的研究の潮流と限界2015

    • Author(s)
      中山敦雄
    • Organizer
      胎児・新生児神経研究会
    • Place of Presentation
      浜松市
    • Year and Date
      2015-12-06
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 発達障害研究のための歯髄幹細胞バンクの構築2015

    • Author(s)
      松木亨、深田斉秀、中山敦雄
    • Organizer
      日本組織培養学会
    • Place of Presentation
      広島
    • Year and Date
      2015-05-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 自閉症感受性遺伝子NLGN4Xの発現解析とその制御機構2015

    • Author(s)
      中山敦雄, 深田斉秀, 飯尾明生, 青木英子
    • Organizer
      日本病理学会総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2015-05-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] 自閉症感受性遺伝子NLGN4Xの発現解析とその制御機構2015

    • Author(s)
      中山敦雄、深田斉秀、飯尾明生、青木英子
    • Organizer
      日本病理学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-05-02
    • Related Report
      2014 Research-status Report
  • [Presentation] An Investigation for epigenetic regulation of the expression of the autism-susceptibility gene, Neuroligin 4X (NLGN4X)2013

    • Author(s)
      Akio Iio, Eiko Aoki, Masahide Fukada, Atsuo Nakayama
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸国際展示場
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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