Evaluation of anti-NMDAR antibodies in the patients with psychiatric and sleep disorders.
| Project/Area Number |
24591696
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | Akita University |
|---|
Principal Investigator |
SHIMIZU Tetsuo 秋田大学, 医学(系)研究科(研究院), 教授 (90170977)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 抗NMDA受容体抗体 / パーキンソン症候群 / ヒスタミン / オレキシン / NMDA受容体抗体 / ナルコレプシー / 緊張病 / 非定型精神病 / 抗NMDA受容体 / てんかん / 難治例の統合失調症 / 多系統萎縮症 / 進行性核上性麻痺 |
|---|
| Outline of Final Research Achievements |
The catatonic symptoms can occur in young females with ovarian teratomas and are associated with autoantibodies to the NMDA receptor (NMDAR). The study included a total of 180 patients. 25 cases were NMDAR antibody positive, including, catatonia cases (n=7), sleep disorders (n=6), atypical psychosis (n=8). Further research of NMDAR antibody and this encephalitis would be important clues for the investigation of schizophrenia and catatonia.
The CSF histamine levels in progressive supra nuclear palsy (PSP:351 pg/ml) and corticobasal degeneration (CBD:306 pg/ml) were lower compared to multiple system atrophy (MSA:2651 pg/ml). The levels of orexin were within normal range in all subjects. Since PSP and CBD are classified tauopathy, and MSA is classified synucleinopathy. Although the differential diagnosis of parkinsonian syndromes is considered one of the most challenging in clinical neurology, the histamine levels could be used for the diagnosis.
|
Report
(4 results)
Research Products
(69 results)
-
-
[Journal Article] Symptomatic narcolepsy or hypersomnia, with and without hypocretin (orexin) deficiency2015
Author(s)
Kanbayashi T, Imanishi A, Ohmori Y, Sagawa Y, Takahashi Y, Omokawa M, Sato M, Hishikawa Y, Shimizu T, Nishino S
-
Journal Title
Narcolepsy, 2nd Edition: A Clinical Guide
Volume: in press
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Association between heart rate variability, blood pressure and autonomic activity in cyclic alternating pattern during sleep .2014
Author(s)
Kondo H, Ozone M, Ohki N, Sagawa Y, Yamamichi K, Fukuju M, Yoshida T, Nishi C, Kawasaki A, Mori K, Kanbayashi T, Izumi M, Hi shikawa Y, Nishino S, Shimizu T.
-
Journal Title
Sleep.
Volume: 37(1)
Pages: 187-194
Related Report
Peer Reviewed
-
-
[Journal Article] Efficacy and safety of rotigotine in Japanese patients with restless legs syndrome: a phase 3, multicenter, randomized, placebo-controlled, double -blind, parallel-group study.2013
Author(s)
Inoue Y, Shimizu T, Hirata K, Uchimura N, Ishigooka J, Oka Y, Ikeda J, Tomida T, Hattori N.
-
Journal Title
Sleep Med.
Volume: 14(11)
Pages: 1085-1091
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Anti-NMDA-receptor antibody detected in encephalitis, schizophrenia, and narcolepsy with psychotic features2012
Author(s)
K Tsutsui, T Kanbayashi, K Tanaka, S Boku, W Ito, J Tokunaga, A Mori, Y Hishikawa, T Shimizu, S Nishino
-
Journal Title
BMC Psychiatry
Volume: 12
Issue: 1
Pages: 37-37
DOI
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] PNEA SOUND ANALYSIS BY ACOUSTIC SPECTROGRAPHY AND FAST FOURIER TRANSFORM (FFT) WITH HIGH-RESOLUTION APNEA SOUND DETECTED BY A PIEZOELECTRIC SENSOR.2013
Author(s)
Sato, S., Kanbayashi, T., Sagawa, Y., Tokunaga, J., Sato, M., Sakai, N., Shimizu, T., Nishino, S.
Organizer
The 27th Annual Meeting of the Associated Professional Sleep Societies
Place of Presentation
Baltimore, USA.
Related Report
-
[Presentation] SLEEP FACILITATION BY ARTIFICIAL CARBONATED BATHING; EEG, CORE, PROXIMAL, AND DISTAL TEMPERATURE EVALUATIONS.2013
Author(s)
Ito, S., Kanbayashi, T., Wakasa, M., Ito, W., Yoshida, M., Shimizu, K., Echizenya, M., Shimizu, T., Nishino, S
Organizer
The 27th Annual Meeting of the Associated Professional Sleep Societies
Place of Presentation
Baltimore, USA.
Related Report
-
[Presentation] CSF QRFP CONCENTRATIONS IN NARCOLEPSY, NEUROLOGICAL AND PSYCHIATRIC DISORDERS.2013
Author(s)
Kanbayashi, T., Sagawa, Y., Imanishi, A., Takahashi, Y., Suda, H., Takahashi, J., Tokunaga, J., Sato, M., Sato, S., Shimizu, T.
Organizer
The 27th Annual Meeting of the Associated Professional Sleep Societies
Place of Presentation
Baltimore, USA.
Related Report
-
[Presentation] SF HYPOCRETIN LEVEL IN PATIENTS WITH MYOTONIC DYSTROPHY.2013
Author(s)
Imanishi, A., Kubota, H., Narita, E., Ishikawa, H., Tsutsui, K., Omori, Y., Sasaki, T., Ataka, K., Kanbayashi, T., Shimizu, T.
Organizer
The 27th Annual Meeting of the Associated Professional Sleep Societies
Place of Presentation
Baltimore, USA.
Related Report
-
[Presentation] CSF QRFP Concentrations in Narcolepsy, Neurological and Psychiatric Disorders.2013
Author(s)
Kanbayashi, T., Sagawa, Y., Imanishi, A., Takahashi, Y., Suda, H., Takahashi, J., Tokunaga, J., Sato, M., Sato, S., Shimizu, T.
Organizer
The 27th Annual Meeting of the Associated Professional Sleep Societies
Place of Presentation
Baltimore, USA.
Related Report
-
[Presentation] SYMPTOMATIC NARCOLEPSY AMONG INHERITED DISORDERS, SUCH AS NIEMANN-PICK TYPE C AND MYOTONIC DYSTROPHY TYPE 1.2013
Author(s)
Kanbayashi, T., Imanishi, A., Tokunaga, J., Sagawa, Y., Takahashi, Y., Suda, H., Takahashi, J., Kikuchi, Y., Shimizu, T
Organizer
Asian narcolepsy symposium
Place of Presentation
Seoul, Korea.
Related Report
-
-
-
-
-
[Presentation] 非定型精神病や精神症状をともなうナルコレプシーにおけるNMDA受容体抗体陽性の症例群.2013
Author(s)
神林 崇, 筒井 幸, 田中恵子, 朴 秀賢, 今西 彩, 吉田 祥, 佐川洋平, 須田秀可, 佐藤紳一, 徳永 純, 上村佐知子, 湯浅稚子, 森 朱音, 佐々木倫子, 清水徹男
Organizer
第38回日本睡眠学会定期学術集会
Place of Presentation
秋田キャッスルホテル
Related Report
-
-
[Presentation] 筋強直性ジストロフィー患者における髄液中オレキシン濃度.2013
Author(s)
今西 彩, 久保田弘樹, 佐川洋平, 徳永 純, 筒井 幸, 石川勇仁, 大森佑貴, 佐々木倫子, 安宅慶一郎, 成田恵理子, 高橋 淳, 須田秀可, 高橋裕也, 神林 崇, 清水徹男
Organizer
第38回日本睡眠学会定期学術集会
Place of Presentation
秋田キャッスルホテル
Related Report
-
[Presentation] 過眠症状を認めるパーキンソン病と進行性核上性麻痺におけるオレキシン神経系の関与についての検討.2013
Author(s)
高橋裕哉, 徳永 純, 今西 彩, 佐川洋平, 筒井 幸, 伊東若子, 若井正一, 服部優子, 高梨雅史, 油川陽子, 神林 崇, 清水徹男
Organizer
第38回日本睡眠学会定期学術集会
Place of Presentation
秋田キャッスルホテル
Related Report
-
-
-
-
-
-
-
-
-
[Presentation] SECONDARY NARCOLEPSY DUE TO NEUROMYELITIS OPTICA, SEVEN CASE SERIES2012
Author(s)
Kanbayashi T, Sagawa Y, Kikuchi Y, Tokunaga J, Ito W, Sato M, Hayashi Y, Takemura T, Aizawa R, Shimizu T
Organizer
SLEEP2012
Place of Presentation
The Hynes Convention Center
Related Report
