Comprehensive research on the pain-relieving effects of duloxetine in BMS patients
Project/Area Number |
24591703
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Nagoya University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
栗田 賢一 愛知学院大学, 歯学部, 教授 (40133483)
伊藤 幹子 愛知学院大学, 歯学部, 非常勤講師 (50469003)
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Co-Investigator(Renkei-kenkyūsha) |
OZAKI Norio 名古屋大学, 医学系研究科, 教授 (40281480)
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Research Collaborator |
YOSHIDA Keizo 株式会社デンソー, 健康推進部, 課長格主任部員
TOKURA Tatsuya 名古屋大学, 医学系研究科, 助教
NAGASHIMA Wataru 名古屋大学, 医学系研究科, 助教
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Project Period (FY) |
2012-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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Keywords | 疼痛性障害 / 口腔内灼熱症候群 / リエゾン精神医学 / 抗うつ剤 |
Outline of Final Research Achievements |
We examine the relationship between the pain-relieving effects of duloxetine, its plasma concentrations and neuroinflammation-related substances (cytokine, chemokine, BDNF, NGF) in patients with chronic nonorganic pain in the orofacial region. Duloxetine significantly relieved pain in patients with chronic nonorganic pain. However, no relationship was observed between its pain-relieving effects and plasma concentrations. Neuroinflammation-related substances is currently under consideration. Additionally we investigated the personality traits of Burning mouth syndrome (BMS) patients. The novelty seeking score was low in BMS patients. They also had high harm avoidance and low self-directedness tendencies. This research was conducted in collaboration with Department of Psychiatry Nagoya University Graduate School of Medicine and Department of Oral and Maxillofacial Surgery School of Dentistry Aichi Gakuin University.
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Report
(7 results)
Research Products
(84 results)
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[Journal Article] Risk of alcohol use relapse after liver transplantation for alcoholic liver disease2017
Author(s)
Yasuharu Onishi, Hiroyuki Kimura, Tomohide Hori, Shinichi Kishi, Hideya Kamei, Nobuhiko Kurata, Chisato Tsuboi, Naoko Yamaguchi, Mayu Takahashi, Saki Sunada, Mitsuaki Hirano, Hiroshige Fujishiro, Takashi Okada, Masatoshi Ishigami, Hidemi Goto, Norio Ozaki, Yasuhiro Ogura
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Journal Title
World Journal of Gastroenterology
Volume: 23
Issue: 5
Pages: 869-875
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Successful Post-Transplant Psychiatric Interventions During Long-Term Follow-Up of Patients Receiving Liver Transplants for Alcoholic Liver Disease2017
Author(s)
Hiroyuki Kimura, Yasuharu Onishi, Shinichi Kishi, Nobuhiko Kurata, Satoshi Ogiso, Hideya Kamei, Chisato Tsuboi, Naoko Yamaguchi, Azusa Shiga, Mai Kondo, Yushun Yokoyama, Fumika Takasato, Hiroshige Fujishiro, Kanako Ishizuka, Takashi Okada, Yasuhiro Ogura, Norio Ozaki
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Journal Title
Am J Case Rep
Volume: 16
Pages: 1215-1219
Related Report
Peer Reviewed
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[Journal Article] Duloxetine Plasma Concentrations and Its Effectiveness in the Treatment of Nonorganic Chronic Pain in the Orofacial Region.2017
Author(s)
Yuka Kobayashi, Wataru Nagashima, Tatsuya Tokura, Keizo Yoshida, Eri Umemura, Tomoya Miyauchi, Munetaka Arao, Mikiko Ito, Hiroyuki Kimura, Kenichi Kurita, Norio Ozaki
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Journal Title
Clin Neuropharmacol
Volume: 40
Pages: 163-168
Related Report
Peer Reviewed
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[Journal Article] Duloxetine Plasma Concentrations and its Effectiveness in the Treatment of Nonorganic Chronic Pain in the Orofacial Region2017
Author(s)
Yuka Kobayashi, Wataru Nagashima, Tatsuya Tokura, Keizo Yoshida, Eri Umemura, Tomoya Miyauchi, Munetaka Arao, Mikiko ito, Hiroyuki Kimura, Kenichi Kurita, Norio Ozaki
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Journal Title
Clinical Neuropharmacology
Volume: 印刷中
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Practices for supporting and confirming decision-making involved in kidney and liver donation by related living donors in Japan: A nationwide survey2016
Author(s)
Katsuji Nishimura, Sayaka Kobayashi, Junko Tsutsui, Hiroaki Kawasaki, Shuichi Katsuragawa, Shun'ichi Noma, Hiroyuki Kimura, Hiroto Egawa, Kenji Yuzawa, Koji Umeshita, Atsushi Aikawa, Shinji Uemoto, Shiro Takahara, Jun Ishigooka
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Journal Title
Am J Transplantation
Volume: 16
Issue: 3
Pages: 860-868
DOI
Related Report
Peer Reviewed
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[Journal Article] The prognostic factors and trajectory of HRQOL in patients with pancreatic cancer who received psychiatric intervention.2016
Author(s)
Hiroyuki Sugimoto, Hiroki Kawashima, Eizaburou Ohno, Daijiro Hayashi, Tomoaki Takeyama, Takeshi Yamamura, Kohei Funasaka, Masanao Nakamura, Ryoj Miyahara, Osamu Watanabe, Masatoshi Ishigami, Miho Suzuki, Hiroyuki Kimura, Norio Ozaki, Senju Hashimoto, Hidemi Goto, Yoshiaki Hirooka et al
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Journal Title
J Gastroenterol Hepatol
Volume: 31
Issue: 3
Pages: 685-690
DOI
Related Report
Peer Reviewed
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[Journal Article] Postoperative psychiatric complications in living liver donors2015
Author(s)
Hiroyuki Kimura、Yasuharu Onishi、Saki Sunada、Shinichi Kishi、Nobuyuki Suzuki、Chisato Tsuboi、Naoko Yamaguchi、Hisashi Imai、 Hideya Kamei、Satoshi Fujisiro、Takashi Okada、Masatoshi Ishigami、Yasuhiro Ogura、Tetsuya Kiuchi、Norio Ozaki
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Journal Title
Transplant Proc
Volume: 47
Issue: 6
Pages: 1860-1865
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Reliability and Validity of the Japanese Version of BEMIB Modified for Patients With Bipolar Disorder: a Self-rating Scale for Medication Adherence2012
Author(s)
Tatsuya Tokura, Hiroyuki Kimura, Akira Yoshimi, Mitsuki Ohashi, Mie Masuda, Koji Senzaki, Keizo Yoshida, Branko Aleksic, Yukihiro Noda, Kiyofumi Yamada, Norio Ozaki
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Journal Title
Clin Neuropsychopharmacol Ther.
Volume: 3
Pages: 26-32
NAID
Related Report
Peer Reviewed
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[Presentation] 口腔顔面領域における疼痛性障害に対するDuloxetineの疼痛軽減効果と血中濃度の関連について.2014
Author(s)
小林由佳, 長島渉, 徳倉達也, 木村宏之, 伊藤幹子, 荒尾宗孝, 宮内倫也, 梅村恵理, 立花昌子, 栗田賢一, 尾崎紀夫.
Organizer
第24回日本臨床精神神経薬理学会・第44回日本神経精神薬理学会 合同年会.
Place of Presentation
名古屋国際会議場(愛知県名古屋市)
Year and Date
2014-11-20 – 2014-11-22
Related Report
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[Presentation] 血小板におけるユビキチン化セロトニントランスポーターの発現とパーソナリティとの関連性.2014
Author(s)
横山美里, 毛利彰宏, 木村真理, 椿井朋, 肥田裕丈, 木村宏之, 徳倉達也, 吉見陽, 河野直子, 國本正子, 尾崎紀夫, 鍋島俊隆, 野田幸裕.
Organizer
第24回日本臨床精神神経薬理学会・第44回日本神経精神薬理学会 合同年会.
Place of Presentation
名古屋国際会議場(愛知県名古屋市)
Year and Date
2014-11-20 – 2014-11-22
Related Report
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[Presentation] Psychiatric profiles of patients with oral psychosomatic disorders 16-year study in Japan.2014
Author(s)
Umemura E, Ito M, Nagashima W, Tokura Tatsuya, Kimura Hiroyuki, Arao Munetaka, Kobayashi Yuka, Miyauchi T, Ozaki Norio, Kurita Kenichi
Organizer
AAOMS 96th Annual Meeting, Scientific Sessions & Exhibition in conjunction with the Japanese Society and Korean Association of Oral and Maxillofacial Surgeons
Place of Presentation
Hawaii Convention Center (Hawaii, USA)
Year and Date
2014-09-08 – 2014-09-13
Related Report
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[Presentation] 末梢血におけるセロトニントランスポーターの代謝調節と情動性の関連解析.2014
Author(s)
・毛利彰宏, 横山美里, 木村真理, 椿井 朋, 肥田裕丈, 木村宏之, 徳倉達也, 吉見陽, 河野直子, 國本正子, 尾崎紀夫, 鍋島俊隆, 野田幸裕
Organizer
次世代を担う創薬・医療薬理シンポジウム2014
Place of Presentation
近畿大学東大阪キャンパス(大阪府東大阪市)
Year and Date
2014-08-30
Related Report
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