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Exploring neural substrates of heterogeneity of schizophrenia with a data-driven approach

Research Project

Project/Area Number 24591706
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionKyoto University

Principal Investigator

SUGIHARA Genichi  京都大学, 医学(系)研究科(研究院), 助教 (70402261)

Co-Investigator(Kenkyū-buntansha) OISHI Naoya  京都大学, 医学研究科, 助教 (40526878)
MIYATA Jun  京都大学, 医学研究科, 助教 (90549099)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords統合失調症 / 脳画像解析 / 神経画像 / 自己組織化マップ / 異種性
Outline of Final Research Achievements

Schizophrenia is a syndrome with with multiple etiologies and symptoms, that is, heterogeneous. Although recent neuroimaging studies have revealed alterations of brain structure and function in the disorder, the majorities of the studies have not paid attention to the heterogeneity of schizophrenia. We explored neural substrates of the heterogeneity with a neuroimaging data-driven approach, i.e., the self-organizing map analysis. With this approach using data of patterns of cortical thickness, we identified several clusters in schizophrenia patients. In addition, some clusters were linked to clinical characteristics, such as medication and symptoms. Our findings suggest that the approach using the self-organizing map enables us to address the heterogeneity of schizophrenia.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (5 results)

All 2015 2014 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 2 results) Presentation (2 results)

  • [Journal Article] Impaired empathic abilities and reduced white matter integrity in schizophrenia.2014

    • Author(s)
      Fujino, J., Takahashi, H., Miyata, J., Sugihara, G., Kubota, M., Sasamoto, A., Fujiwara, H., Aso, T., Fukuyama, H., & Murai, T.
    • Journal Title

      Progress in Neuropsychopharmacology & Biological Psychiatry

      Volume: 48 Pages: 117-123

    • DOI

      10.1016/j.pnpbp.2013.09.018

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Global association between cortical thinning and white matter integrity reduction in schizophrenia.2014

    • Author(s)
      Sasamoto, A., Miyata, J., Kubota, M., Hirao, K., Kawada, R., Fujimoto, S., Tanaka, Y., Hazama, M., Sugihara, G., Sawamoto, N., Fukuyama, H., Takahashi, H., & Murai, T.
    • Journal Title

      Schizophrenia Bulletin

      Volume: 40 Issue: 2 Pages: 420-427

    • DOI

      10.1093/schbul/sbt030

    • NAID

      120005619771

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Renaming schizophrenia coupled with proper public education is an optimal way to overcome stigma2013

    • Author(s)
      Sugihara G, Takei N
    • Journal Title

      Psychol Med

      Volume: 43 Issue: 7 Pages: 1557-8

    • DOI

      10.1017/s0033291713000901

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 大脳皮質厚減少のパターンによる統合失調症における亜型の解明:自己組織化マップによる新規脳画像解 析2015

    • Author(s)
      杉原玄一、大石直也、孫樹洛、佐々木仁、村井俊哉
    • Organizer
      第10回日本統合失調症学会
    • Place of Presentation
      東京
    • Year and Date
      2015-03-27 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Self Organizing Map Analysis of Regional Brain Volume Revealed Subgroups in Schizophrenia2012

    • Author(s)
      Genichi Sugihara, Naoya Oishi, Shinsuke Fujimoto, Jun Miyata, Toshiya Murai
    • Organizer
      3rd Biennial Schizophrenia International Research Conference
    • Place of Presentation
      Florence, Italy
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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