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Study about the neurological bases of impulsivity on eating disorders with binge eating

Research Project

Project/Area Number 24591707
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionKyoto University

Principal Investigator

NOMA Shun'ichi  京都大学, 医学(系)研究科(研究院), 講師 (40314190)

Co-Investigator(Kenkyū-buntansha) UWATOKO Teruhisa  京都大学, 保健管理センター, 助教 (20447973)
SUGIHARA Genichi  京都大学, 医学(系)研究科(研究院), 助教 (70402261)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords摂食障害 / 衝動性 / 脳機能画像 / 報酬系 / 自閉症傾向 / 神経基盤 / 報酬系課題 / 反応抑制系課題 / 機能的MRI
Outline of Final Research Achievements

The participants of this study were tha female patients who were diagnosed as eating disorders by DSM-IV and the female healthy control group. They were tested by psychological examinations and fuctional magnetic resonance imaging (fMRI). The activities of the left orbitofrontal cortex, that was pointed out to be related to the sensitivity of punishment, of the subjects of the patients group were significantly higher than those of the control group. Moreover, the results of the Autism-Spectrum Quotient (AQ) of the subjects of the patients group were significantly higher than those of the control group, and the volumes of the dorsal anterior cingulate cortex of the subjects of the eating disorder group significantly reducted more than those of the control group. Consequently, the patients with eating disorders might have the tendency to autism and hypersensitivity of prospect of reward and punishment, and these tendency might be influenced by brain structure related to sociality.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2015

All Presentation (2 results)

  • [Presentation] 摂食障害患者における脳構造変化と自閉症傾向2015

    • Author(s)
      村尾英真、磯部昌憲、川端美智子、野田智美、松河理子、孫樹洛、鶴身孝介、川田良作、杉原玄一、上床輝久、高橋英彦、村井俊哉、野間俊一
    • Organizer
      第56回日本心身医学会総会ならびに学術集会
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      2015-06-26 – 2015-06-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] fMRIを用いた摂食障害患者における脳内報酬系の脳活動に関する研究2015

    • Author(s)
      村尾英真、磯部昌憲、川端美智子、野田智美、松河理子、孫樹洛、鶴身孝介、川田良作、杉原玄一、上床輝久、高橋英彦、村井俊哉、野間俊一
    • Organizer
      第111回日本精神神経学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2015-06-04 – 2015-06-06
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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