neuroanatomical basis of memory complaints in individuals with subjective cognitive impairment

• Project/Area Number: 24591708
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Osaka University
• Principal Investigator: KAZUI Hiroaki 大阪大学, 医学(系)研究科(研究院), 講師 (30346217)
• Co-Investigator(Kenkyū-buntansha): TANAKA Toshihisa 大阪大学, 医学(系)研究科(研究院), 准教授 (10294068) ; YASUNO Fumihiko 奈良県立医科大学, 医学部, 准教授 (60373388)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 主観的認知機能障害 / 記憶 / 認知症 / 機能的MRI / 拡散テンソル画像 / アミロイドPET / 神経心理学 / 神経画像 / 記憶障害 / 脳内基盤 / SCI / SMI

Outline of Final Research Achievements

Subjective cognitive impairment (SCI) is a clinical state characterized by subjective cognitive deficits without cognitive impairment. To test the hypothesis that this state might involve dysfunction of self referential processing mediated by cortical midline structures, we performed functional connectivity analysis using resting-state functional magnetic resonance imaging　for 23 individuals with SCI and 30 individuals without SCI. Individuals with SCI showed reduced functional connectivity in cortical midline structures. Changes in white matter connections, which were measured using magnetic resonance-diffusion tensor imaging, was related to reduced functional connectivity, but we found no correlations between amyloid deposition and functional connectivity. The results imply that reduced functional connectivity in cortical midline structures contributes to overestimation of the experience of forgetfulness.

Research Products

• [Journal Article] Resting-state synchrony between the retrosplenial cortex and anterior medial cortical structures relates to memory complaints in subjective cognitive impairment (2015)
  • Author(s): Fumihiko Yasuno, Hiroaki Kazui, Akihide Yamamoto, Naomi Morita, Katsufumi Kajimoto, Masafumi Ihara, Akihiko Taguchi, Kiwamu Matsuoka, Jun Kosaka, Toshihisa Tanaka, Takashi Kudo, Masatoshi Takeda, Kazuyuki Nagatsuka, Hidehiro Iida, Toshifumi Kishimoto
  • Journal Title: Neurobiology of Aging Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 初期症状としての記憶障害の捉え方 (2015)
  • Author(s): 数井裕光、武田雅俊
  • Journal Title: 老年精神医学雑誌 Volume: 26 Pages: 33-9
• [Journal Article] Delayed atrophy in posterior cingulate cortex and apathy after stroke. (2015)
  • Author(s): MatsuokaMatsuoka K, Yasuno F, Taguchi A, Yamamoto A, Kajimoto K, Kazui H, Kudo T, Sekiyama A, Kitamura S, Kiuchi K, Kosaka J, Kishimoto T, Iida H, Nagatsuka K
  • Journal Title: Int J Geriatr Psychiatry Volume: 30 Issue: 6 Pages: 566-572
  • DOI: 10.1002/gps.4185
  • Peer Reviewed
• [Journal Article] Microstructural abnormality in white matter, regulatory T lymphocytes, and depressive symptoms after stroke. (2014)
  • Author(s): Yasuno F, Taguchi A, Yamamoto A, Kajimoto K, Kazui H, Kudo T, Kikuchi-Taura A, Sekiyama A, Kishimoto T, Iida H, Nagatsuka K.
  • Journal Title: Psychogeriatrics Volume: 14 Issue: 9 Pages: 213-21
  • DOI: 10.1002/gps.4235
  • Peer Reviewed
• [Journal Article] Microstructural abnormalities in white matter and their effect on depressive symptoms after stroke. (2014)
  • Author(s): Yasuno F, Taguchi A, Yamamoto A Kajimoto K, Kazui H, Sekiyama A, Matsuoka K, Kitamura S, Kiuchi K, Kosaka J, Kishimoto T, Iida H, Nagatsuka K
  • Journal Title: Psychiatry Res Volume: 223 Issue: 1 Pages: 9-14
  • DOI: 10.1016/j.pscychresns.2014.04.009
  • Peer Reviewed
• [Journal Article] Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as as amyloid beta accumulation modifier (2014)
  • Author(s): Morihara, T., Hayashi, N., Yokokoji, M., Akatsu, H., Silverman, MA., Kimura, N., Saito, Y., Suzuki, T., Yanagida, K., Tanaka, T., Kazui, H., Kudo, T., Kodama, TS., Sato, M., Hashimoto, R., Tagami, S., Okochi, M., Ytoh, N., Nishitomi, K., Takamura, H., Katayama, T., Hashizumi, Y., Kimura, R., Kamino, K., Takeda, M
  • Journal Title: Proc. Acad. Natl. Sci. USA Volume: 111 Issue: 7 Pages: 2638-2643
  • DOI: 10.1073/pnas.1307345111
  • Peer Reviewed / Open Access
• [Journal Article] Relation between remission status and attention in patients withn schizophrenia. (2014)
  • Author(s): Fukumoto M, et al.
  • Journal Title: Psychiatry and Clinical Neurosciences, Volume: 68(3) Issue: 3 Pages: 234-41
  • DOI: 10.1111/pcn.12119
  • Peer Reviewed
• [Journal Article] アルツハイマー病における扁桃体萎縮と症候 (2014)
  • Author(s): 数井裕光、吉山顕次、武田雅俊
  • Journal Title: Clinical Neuroscience Volume: 32 Pages: 662-4
• [Journal Article] アルツハイマー病の早期診断における臨床診断基準と神経心理検査の有用性 (2013)
  • Author(s): 数井裕光、田中稔久、安野史彦、武田雅俊
  • Journal Title: Dementia Japan Volume: 27 Pages: 316-323
• [Journal Article] Predictors of the disappearance of triad symptoms in patients with idiopathic normal pressure hydrocephalus after shunt surgery. (2013)
  • Author(s): Kazui H, Mori E, Ohkawa S, Okada T, Kondo T, Sakakibara R, Ueki O, Nishio Y, Ishii K, Kawaguchi T, Ishikawa M, Takeda M.
  • Journal Title: J Neurol Sci Volume: 328 Issue: 1-2 Pages: 64-9
  • DOI: 10.1016/j.jns.2013.02.020
  • Peer Reviewed
• [Journal Article] Predictors of prolonged hospital stay for the treatment of severe neuropsychiatric symptoms in patients with dementia: a cohort study in multiple hospitals (2013)
  • Author(s): Sugiyama H, Kazui H(CA), Shigenobu K, Masaki Y, Hatta N, Yamamoto D, Wada T, Nomura K, Yoshiyama K, Tabushi K, Takeda M
  • Journal Title: Int Psychogeriatr Volume: 23 Issue: 8 Pages: 1-9
  • DOI: 10.1017/s1041610213000483
  • Peer Reviewed
• [Journal Article] Association between milder brain deformation before a shunt operation and improvement in cognition and gait in idiopathic normal pressure hydrocephalus (2013)
  • Author(s): Yamamoto D, Kazui H(CA), Wada T, Nomura K, Sugiyama H, Shimizu Y, Yoshiyama K, Yoshida T, Kishima H, Yamashita F, Yoshimine T, Takeda M
  • Journal Title: Dement Geriatr Cogn Disord Volume: 35 Issue: 3-4 Pages: 197-207
  • DOI: 10.1159/000347147
  • Peer Reviewed
• [Journal Article] Possible roles of the dominant uncinate fasciculus in naming objects: a case report of intraoperative electrical stimulation on a patient with a brain tumour (2013)
  • Author(s): Nomura K, Kazui H, Tokunaga H, Hirata M, Goto T, Goto Y, Hashimoto N, Yoshimine T, Takeda M.
  • Journal Title: Behav Neurol Volume: 27 Pages: 229-34
  • Peer Reviewed
• [Journal Article] EEG and Neuronal Activity Topography analysis can predict effectiveness of shunt operation in idiopathic normal pressure hydrocephalus patients. (2013)
  • Author(s): Aoki Y, Kazui H, Tanaka T, Ishii R, Wada T, Ikeda S, Hata M, Canuet L, Musha T, Matsuzaki H, Imajo K, Yoshiyama K, Yoshida T, Shimizu Y, Nomura K, Iwase M, Takeda M
  • Journal Title: Neuroimage Clin Volume: 3 Pages: 522-530
  • DOI: 10.1016/j.nicl.2013.10.009
  • Peer Reviewed
• [Journal Article] The impact of the genome-wide supported variant in the cyclin M2 gene on gray matter morphology in schizophrenia. (2013)
  • Author(s): Ohi K, et al.
  • Journal Title: Behavioral and Brain Functions, Volume: 9(1) Issue: 1 Pages: 40-40
  • DOI: 10.1186/1744-9081-9-40
  • Peer Reviewed
• [Journal Article] Influence of the NRGN gene on intellectual ability in schizophrenia. (2013)
  • Author(s): Ohi K, et al.
  • Journal Title: Journal of Human Genetics, Volume: 58(10) Issue: 10 Pages: 700-5
  • DOI: 10.1038/jhg.2013.82
  • Peer Reviewed
• [Journal Article] Genome-wide association study of cognitive decline in schizophrenia. (2013)
  • Author(s): Hashimoto R, et al.
  • Journal Title: Am J Psychiatry Volume: 170(6) Issue: 6 Pages: 683-4
  • DOI: 10.1176/appi.ajp.2013.12091228
  • Peer Reviewed
• [Journal Article] Behavioral and Psychological Symptoms of Dementia (BPSD)の治療目的で精神科救急を受診する高齢患者の実態調査 (2013)
  • Author(s): 清水芳郎、数井裕光、澤 温、武田雅俊
  • Journal Title: 精神神経学雑誌 Volume: 115 Pages: 1113-21
  • NAID: 40019880175
  • Peer Reviewed
• [Journal Article] Reversibility of brain morphology after shunt operations and preoperative clinical symptoms in patients with idiopathic normal pressure hydrocephalus. (2012)
  • Author(s): Wada T
  • Journal Title: Psychogeriatrics Volume: 13(1) Issue: 1 Pages: 41-48
  • DOI: 10.1111/psyg.12001
  • Peer Reviewed
• [Journal Article] Classification of delusions in Alzheimer's disease and their neural correlates (2012)
  • Author(s): Nomura K, Kazui H(CA), Wada T, Sugiyama H, Yamamoto D, Yoshiyama K, Shimosegawa E, Hatazawa J, Takeda M..
  • Journal Title: Psychogeriatrics Volume: 12 Issue: 3 Pages: 200-10
  • DOI: 10.1111/j.1479-8301.2012.00427.x
  • Peer Reviewed
• [Journal Article] Distribution of Cortical Benzodiazepine Receptor Binding in Right-Handed Healthy Humans : A voxel-Based statistical Analysis of Iodine 123 Iomazenil SPECT with Partial Volume Correction (2012)
  • Author(s): Kato H, Shimosegawa E, Isohashi K, Kimura N, Kazui H, Hatazawa J
  • Journal Title: AJNR Am J Neuroradiol Volume: (Epub ahead of print) Issue: 8 Pages: 1458-63
  • DOI: 10.3174/ajnr.a3005
  • Peer Reviewed
• [Journal Article] Personality traits and schizophrenia : evidence from a case-control study and meta-analysis (2012)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Iwase M, Kazui H, Takeda M
  • Journal Title: Psychiatry Res Volume: (Epub ahead of print) Issue: 1 Pages: 7-11
  • DOI: 10.1016/j.psychres.2011.12.018
  • Peer Reviewed
• [Journal Article] A promoter variant in the chitinase 3-like 1 gene is associated with serum YKL-40 level and personality trait (2012)
  • Author(s): Yamamori H, Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Kasahara E, Sekiyama A, Umeda-Yano S, Okada T, Iwase M, Kazui H, Ito A, Takeda M
  • Journal Title: Neurosci Lett Volume: (Epub ahead of print) Issue: 2 Pages: 204-208
  • DOI: 10.1016/j.neulet.2012.02.039
  • Peer Reviewed
• [Journal Article] Impact of the genome wide supported NRGN gene on anterior cingulate morphology in schizophrenia (2012)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Nemoto K, Ohnishi T, Fukumoto M, Yamaniori H, Umeda-Yano S, Okada T, Iwase M, Kazui H, Takeda M
  • Journal Title: PLoS One Volume: 7(1) Issue: 1 Pages: e29780-e29780
  • DOI: 10.1371/journal.pone.0029780
  • Peer Reviewed
• [Presentation] 連携ノートを利用した地域連携・教育システムの有用性 (2014)
  • Author(s): 数井裕光
  • Organizer: 第33回日本認知症学会学術総会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-11-29 – 2014-12-01
  • Invited
• [Presentation] これからの認知症診療 (2014)
  • Author(s): 数井裕光
  • Organizer: 第38回日本高次脳機能障害学会学術総会
  • Place of Presentation: 仙台市
  • Year and Date: 2014-11-28 – 2014-11-29
  • Invited
• [Presentation] 認知症と生きる ～認知症になっても安心して暮らすために～ (2014)
  • Author(s): 数井裕光
  • Organizer: 第２９回大阪府作業療法学会 特別講演
  • Place of Presentation: 大阪市
  • Year and Date: 2014-11-09
  • Invited
• [Presentation] 変性性認知症剖検例の症候と診断 (2014)
  • Author(s): 数井裕光
  • Organizer: 第38回日本神経心理学会学術集会 ケースカンファレンス
  • Place of Presentation: 山形市
  • Year and Date: 2014-09-26 – 2014-09-27
  • Invited
• [Presentation] 記憶障害とその対応 (2014)
  • Author(s): 数井裕光
  • Organizer: 2014年夏期教育研修講座Bコース
  • Place of Presentation: 名古屋市
  • Year and Date: 2014-07-21
  • Invited
• [Presentation] 認知障害の初期症状 (2014)
  • Author(s): 数井裕光
  • Organizer: アルツハイマー病研究会第15回学術シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2014-04-19
  • Invited
• [Presentation] Association between milder brain deformation before a shunt operation and improvement in cognition and gait in idiopathic normal pressure hydrocephalus. (2013)
  • Author(s): Hiroaki Kazui, Daisuke Yamamoto, Tamiki Wada, Keiko Nomura, Hiromichi Sugiyama, Yoshiro Shimizu, Kenji Yoshiyama, Haruhiko Kishima, Fumio Yamashita, Masatoshi Takeda
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto
• [Presentation] Impacts of the genome-wide association mega-analysis supported variants on brain morphology in schizophrenia; a comprehensive VBM analysis. (2013)
  • Author(s): Kazutaka Ohi, Ryota Hashimoto, Yuka Yasuda, Kiyotaka Nemoto, Takashi Ohnishi, Michiyo Fujimoto, Hidenaga Yamamori, Satomi Umeda-Yano, Masao Iwase, Hiroaki Kazui, Masatoshi Takeda.
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto
• [Presentation] Neural Correlates of two-way anomia in semantic dementia. (2013)
  • Author(s): Keiko Nomura, Hiroaki Kazui, Kenji Yoshiyama, Tetsuhiko Yoshida, Hiromichi Sugiyama, Daisuke Yamamoto, Yoshiro Shimizu, Masatoshi Takeda
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto
• [Presentation] MEG revealed induced oscillatory power changes related with visual-object working memory dysfunction in patients with Alzheimer's disease and mild cognitive impairment. (2013)
  • Author(s): Ryouhei Ishii、 Yasunori Aoki Shunichiro Ikeda Masahiro Hata Leonides Canuet Hiroaki Kazui Masao Iwase Masatoshi Takeda
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto
• [Presentation] Reversibility of brain morphology after shunt operations and preoperative clinical symptoms in patients with idiopathic normal pressure hydrocephalus. (2013)
  • Author(s): Tamiki Wada, Hiroaki Kazui, Daisuke Yamamoto, Haruhiko Kishima, Fumio Yamashita, Keiko Nomura, Hiromichi Sugiyama, Yoshiro Shimizu, Kenji Yoshiyama, Tetsuhiko Yoshida, Toshiki Yoshimine, Masatoshi Takeda.
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto
• [Presentation] EEG analysis using Neural Activity Topography in iNPH patients before and after CSF Tapping. (2013)
  • Author(s): Yasunori Aoki, Hiroaki Kazui, Ryouhei Ishii, Tamiki Wada, Daisuke Yamamoto, Haruyasu Matsuzaki, Kaoru Imajo, Toshimitsu Musha, Masao Iwase, Masatoshi Takeda.
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto
• [Presentation] Neural responses to biological motion: A MEG study. (2013)
  • Author(s): Kenji Yoshiyama, Akinori Nakamura, Diers Kersten, Masahiko Bundo, Kentaro Ono, Yoshiya Mori, Hideyuki Hattori, Hiroaki Kazui, Masatoshi Takeda, Kengo Ito.
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto
• [Presentation] Tissue oxygen index of NIRS forehead signals during performing frontal lobe tasks in schizophrenia. (2013)
  • Author(s): Masao Iwase, Michiyo Azechi, Hidetoshi Takahashi, Yasunori Aoki, Shunichiro Ikeda, Masahiro Hata, Ryouhei Ishii, Hiroaki Kazui, Kazutaka Ohi, Yuka Yasuda, Ryota Hashimoto, Masatoshi Takeda, Hidenaga Yamamori.
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto
• [Presentation] Microstructural abnormality in white matter, regulatory T lymphocytes and depressive symptoms after stroke. (2013)
  • Author(s): Fumihiko Yasuno, Akihiko Taguchi, Katsufumi Kajimoto, Hiroaki Kazui, Atsuo Sekiyama, Soichiro Kitamura, Kuniaki Kiuchi, Jun Kosaka, Hidehiro Iida, Kazuyuki Nagatsuka, Toshifumi Kishimoto.
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto
• [Presentation] Forehead NIRS signals during Sternberg's task in schizophrenia. (2013)
  • Author(s): Masao Iwase, Michiyo Azechi, Hidetoshi Takahashi, Yasunori Aoki, Shunichiro Ikeda, Masahiro Hata, Ryouhei Ishii, Hiroaki Kazui, Hidenaga Yamamori, Kazutaka Ohi, Michiko Fujimoto, Yuka Yasuda, Ryota Hashimoto.
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto
• [Presentation] 認知症診療における神経画像検査の有用性 (2013)
  • Author(s): 数井裕光
  • Organizer: 第109回日本精神神経学会学術総会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] Two-way anomia in semantic dementia and its neural correlates (2013)
  • Author(s): Keiko Nomura, Hiroaki Kazui, Kenji Yoshiyama, Tetsuhiko Yoshida, Yoshiro Shimizu, Masatoshi Takeda
  • Organizer: Two-way anomia in semantic dementia and its neural correlates
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 記憶障害とその対応 (2013)
  • Author(s): 数井裕光
  • Organizer: 日本高次脳機能障害学会2013年夏期教育研修講座Bコース
  • Place of Presentation: 横浜
  • Invited
• [Presentation] 認知症の症候と対応 (2013)
  • Author(s): 数井裕光
  • Organizer: 第37回日本高次脳機能障害学会学術総会
  • Place of Presentation: 松江
  • Invited
• [Presentation] 認知症に対する疾患別の治療法 ・対応法 (2013)
  • Author(s): 数井裕光
  • Organizer: 第466回 北九州精神科集談会
  • Place of Presentation: 北九州
  • Invited
• [Presentation] 均一な神経病理をもつとされる意味性認知症の脳萎縮パターンの検討 (2013)
  • Author(s): 野村慶子、数井裕光、吉山顕次、吉田哲彦、杉山博通、山本大介、清水芳郎、武田雅俊
  • Organizer: 第28回日本老年精神医学会
  • Place of Presentation: 大阪
• [Presentation] アルツハイマー病の早期診断における神経心理検査の役割と臨床診断基準 (2012)
  • Author(s): 数井裕光
  • Organizer: 第3１回日本認知症学術集会シンポジム2「アルツハイマー病の早期診断・治療のためのガイドラインに向けて：prodromal AD、pre-MCI」
  • Place of Presentation: つくば市
  • Invited
• [Presentation] 病巣で明確でない慢性期患者に対する神経心理学的・精神医学的診療 (2012)
  • Author(s): 数井裕光
  • Organizer: 第７１回日本脳神経外科学会シンポジウム「外傷性高次脳機能障害の診断と問題点」
  • Place of Presentation: 大阪市
  • Invited
• [Presentation] 治療可能な認知症を見逃さないために (2012)
  • Author(s): 数井裕光
  • Organizer: 第4回国際水頭症髄液疾患学会市民公開講座
  • Place of Presentation: 京都市
  • Invited
• [Presentation] 認知症診療のための地域連携 ー連携パスの可能性ー (2012)
  • Author(s): 数井裕光
  • Organizer: 第1回日本精神科医学会学術大会ランチョンセミナー
  • Place of Presentation: 大阪市
  • Invited
• [Presentation] 認知症の診かたと臨床 (2012)
  • Author(s): 数井裕光
  • Organizer: 日本高次脳機能障害学会2012年夏期教育研修講座
  • Place of Presentation: 名古屋市
  • Invited
• [Book] 今日の診療のためのガイドライン外来診療2014 (2014)
  • Author(s): 数井裕光
  • Total Pages: 620
  • Publisher: 日経メディカル開発
• [Book] 認知症ハンドブック (2013)
  • Author(s): 数井裕光
  • Total Pages: 7
  • Publisher: 医学書院
• [Book] 脳血管障害と神経心理学第2版 (2013)
  • Author(s): 数井裕光
  • Total Pages: 7
  • Publisher: 医学書院
• [Book] 脳と心のプライマリケア 第２巻 知能の衰え (2013)
  • Author(s): 数井裕光、武田雅俊
  • Total Pages: 10
  • Publisher: シナジー
• [Book] メディカルレビュー社 (2012)
  • Author(s): 数井裕光、杉山博通、板東潮子
  • Total Pages: 221
  • Publisher: 認知症知って安心!―症状別対応ガイド