The study on prediction of the operation on idiopathic normal pressure hydrocephalus

• Project/Area Number: 24591710
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Osaka University
• Principal Investigator: Yoshiyama Kenji 大阪大学, 医学(系)研究科(研究院), 助教 (20426498)
• Co-Investigator(Kenkyū-buntansha): KUDO TAKASHI 大阪大学, 保健センター, 教授 (10273632) ; 渡邉 嘉之 大阪大学, 医学(系)研究科(研究院), 准教授 (20362733)
• Co-Investigator(Renkei-kenkyūsha): WATANABE YOSHIYUKI 大阪大学, 大学院医学系研究科, 准教授 (20362733)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 特発性正常圧水頭症 / シャント手術 / 脳波 / 形態画像 / 手術 / 歩行障害 / 認知機能障害 / 脳脊髄液排除試験 / シャント術 / 頭部MRI / 髄液検査 / 脳画像

Outline of Final Research Achievements

The symptoms of idiopathic Normal Pressure Hydrocephalus (iNPH) can be reversed by shunt operation, while the symptoms of all patients with iNPH are not reversed. The cerebrospinal fluid (CSF) tap test is effective for prediction of shunt operation. However, CSF tap test is invasive and could not be complete prediction. In this study, we indicate that the association between the degree of deformation of the brain from MRI, which is noninvasive, before shunt operation and improvement of gait and cognitive impairment after shunt operation. We also indicate that Neuronal Activity Topography analysis, which calculates normalized power variance of electroencephalogram and is also noninvasive, could be prediction of shunt operation. And we indicate the effect of shunt operation on neuropsychiatric symptoms and care burden in patients with iNPH.

Research Products

• [Journal Article] Effect of lumbo-peritoneal shunt surgery on neuropsychiatric symptoms in patients with idiopathic normal pressure hydrocephalus. (2016)
  • Author(s): Kanemoto H, Kazui H, Suzuki Y, Sato S, Kishima H, Yoshimine T, Yoshiyama K.
  • Journal Title: J Neurol Sci. Volume: 361 Pages: 206-12
  • DOI: 10.1016/j.jns.2016.01.001
  • Peer Reviewed / Open Access
• [Journal Article] 原著 認知症疾患医療センターにおける特発性正常圧水頭症診療の現状 (2015)
  • Author(s): 吉山顕次、数井裕光、武田雅俊
  • Journal Title: BRAIN and NERVE Volume: 67 Issue: 9 Pages: 1139-1145
  • DOI: 10.11477/mf.1416200273
  • ISSN: 1344-8129, 1881-6096
  • Year and Date: 2015-09-01
  • Peer Reviewed / Open Access
• [Journal Article] 正常圧水頭症 (2015)
  • Author(s): 吉山顕次、数井裕光
  • Journal Title: 認知症の最新医療 Volume: 5 Pages: 194-8
• [Journal Article] Noninvasive prediction of shunt operation outcome in idiopathic normal pressure hydrocephalus. (2015)
  • Author(s): Aoki Y, Kazui H, Tanaka T, Ishii R, Wada T, Ikeda S, Hata M, Canuet L, Katsimichas T, Musha T, Matsuzaki H, Imajo K, Kanemoto H, Yoshida T, Nomura K, Yoshiyama K, Iwase M, Takeda M
  • Journal Title: Scientific reports Volume: 5 Issue: 1 Pages: 1-5
  • DOI: 10.1038/srep07775
  • Peer Reviewed / Open Access
• [Journal Article] EEG and Neuronal Activity Topography analysis can predict effectiveness of shunt operation in idiopathic normal pressure hydrocephalus patients. (2013)
  • Author(s): Aoki Y, Kazui H, Tanaka T, Ishii R, Wada T, Ikeda S, Hata M, Canuet L, Musha T, Matsuzaki H, Imajo K, Yoshiyama K, Yoshida T, Shimizu Y, Nomura K, Iwase M, Takeda M
  • Journal Title: Neuroimage Clin Volume: 3 Pages: 522-530
  • DOI: 10.1016/j.nicl.2013.10.009
  • Peer Reviewed
• [Journal Article] Association between milder brain deformation before a shunt operation and improvement in cognition and gait in idiopathic normal pressure hydrocephalus (2013)
  • Author(s): Yamamoto D, Kazui H(CA), Wada T, Nomura K, Sugiyama H, Shimizu Y, Yoshiyama K, Yoshida T, Kishima H, Yamashita F, Yoshimine T, Takeda M
  • Journal Title: Dement Geriatr Cogn Disord Volume: 35 Issue: 3-4 Pages: 197-207
  • DOI: 10.1159/000347147
  • Peer Reviewed
• [Journal Article] Reversibility of brain morphology after shunt operations and preoperative clinical symptoms in patients with idiopathic normal pressure hydrocephalus. (2012)
  • Author(s): Wada T
  • Journal Title: Psychogeriatrics Volume: 13(1) Issue: 1 Pages: 41-48
  • DOI: 10.1111/psyg.12001
  • Peer Reviewed
• [Journal Article] 特集：認知症最前線ー新薬登場を受けた実地診療のすべて 正常圧水頭症 (2012)
  • Author(s): 数井裕光、吉山顕次、武田雅俊
  • Journal Title: Medical Practice Volume: 29 Pages: 763-767
• [Presentation] Definite iNPHにおける術前のCSF中のアルツハイマー病バイオマーカー値とシャント術3ヶ月後の歩行・認知の改善との関係 (2015)
  • Author(s): 数井裕光,鐘本英輝,吉山顕次,田中稔久,貴島晴彦,鈴木由希子,佐藤俊介,東眞吾,末廣聖,吉峰俊樹,武田雅俊
  • Organizer: 第8回日本水頭症脳脊髄液学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-11-22
  • Invited
• [Presentation] Association between high biomarker probability of Alzheimer's disease and improvement of cognition and gait after shunt surgery in patients with idiopathic normal pressure hydrocephalus. (2015)
  • Author(s): Kazui H, Kanemoto H, Suzuki Y, Sato S, Suehiro T, Azuma S, Yoshiyama K, Tanaka T.
  • Organizer: Hydrocephalus 2015
  • Place of Presentation: Banff Canada
  • Year and Date: 2015-09-18
  • Int'l Joint Research
• [Presentation] Association between apathy and regional cerebral blood flow in patients with idiopathic normal pressure hydrocephalus. (2015)
  • Author(s): Kanemoto H, Kazui H, Suehiro T, Azuma S, Sato S, Suzuki Y, Yoshiyama K.
  • Organizer: Hydrocephalus 2015
  • Place of Presentation: Banff Canada
  • Year and Date: 2015-09-18
  • Int'l Joint Research
• [Presentation] Longitudinal clinical observation of 4 patients with preclinical stage of idiopathic normal pressure hydrocephalus. (2015)
  • Author(s): Azuma S, Suehiro T, Kazui H, Sato S, Suzuki Y, Kanemoto H, Yoshiyama K.
  • Organizer: Hydrocephalus 2015
  • Place of Presentation: Banff Canada
  • Year and Date: 2015-09-18
  • Int'l Joint Research
• [Presentation] Effect of lumboperitoneal shunt on neuropsychiatric symptoms in the patients with idiopathic normal pressure hydrocephalus (2014)
  • Author(s): Hideki Kanemoto, Hiroaki Kazui, Yukiko Suzuki, Shunsuke Sato, Kenji Yoshiyama, Masatoshi Takeda
  • Organizer: Hydrocephalus
  • Place of Presentation: Bristol U.K
  • Year and Date: 2014-09-06 – 2014-09-08
• [Presentation] Variability of functional mobility in patients with idiopathic normal hydrocephalus and its influence on the gait assessment. (2014)
  • Author(s): Yukiko Suzuki, Shunsuke Sato, Hiroaki Kazui, Hideki Kanemoto, Kenji Yoshiyama, Masatoshi Takeda
  • Organizer: Hydrocephalus
  • Place of Presentation: Bristol U.K
  • Year and Date: 2014-09-06 – 2014-09-08
• [Presentation] EEG analysis using Neural Activity Topography in iNPH patients before and after CSF Tapping. (2013)
  • Author(s): Yasunori Aoki, Hiroaki Kazui, Ryouhei Ishii, Tamiki Wada, Daisuke Yamamoto, Haruyasu Matsuzaki, Kaoru Imajo, Toshimitsu Musha, Masao
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto
• [Presentation] Association between milder brain deformation before a shunt operation and improvement in cognition and gait in idiopathic normal pressure hydrocephalus. (2013)
  • Author(s): Hiroaki Kazui, Daisuke Yamamoto, Tamiki Wada, Keiko Nomura, Hiromichi Sugiyama, Yoshiro Shimizu, Kenji Yoshiyama, Haruhiko Kishima, Fumio Yamashita, Masatoshi Takeda.
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto
• [Presentation] Reversibility of brain morphology after shunt operations and preoperative clinical symptoms in patients with idiopathic normal pressure hydrocephalus. (2013)
  • Author(s): Tamiki Wada, Hiroaki Kazui, Daisuke Yamamoto, Haruhiko Kishima, Fumio Yamashita, Keiko Nomura, Hiromichi Sugiyama, Yoshiro Shimizu, Kenji Yoshiyama, Tetsuhiko Yoshida, Toshiki Yoshimine, Masatoshi Takeda.
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto
• [Presentation] Time course of improvement of cognitive and walking performances after transient cerebrospinal fluid tapping in patients with idiopathic normal pressure hydrocephalus. (2012)
  • Author(s): Nomura K, Kazui H, Wada T, Yamamoto D, Sugiyama H, Shimizu Y, Yoshiyama K, Yoshida T, Kishima H, Yoshimine T, Takeda M.
  • Organizer: Hydrocephalus 2012 Kyoto
  • Place of Presentation: Kyoto
• [Presentation] Reversibility of brain after shunt operation and preoperative clinical symptoms in idiopathic normal pressure hydrocephalus (2012)
  • Author(s): Wada T, Kazui H, Yamamoto D, Kishima H, Yamashita F, Nomura K, Sugiyama H, Shimizu Y, Yoshiyama K, Yoshida T, Yoshimine T, Takeda M.
  • Organizer: Hydrocephalus 2012 Kyoto
  • Place of Presentation: Kyoto
• [Presentation] Association between the brain deformation and the improvement of clinical symptoms after shunt operation in idiopathic normal pressure hydrocephalus (2012)
  • Author(s): Yamamoto D, Kazui H, Yamashita F, Sugiyama H, Nomura K, Wada T, Yoshiyama K, Takeda M
  • Organizer: Hydrocephalus 2012 Kyoto
  • Place of Presentation: Kyoto
• [Book] 特発性正常圧水頭症の診療 (2014)
  • Author(s): 吉山顕次、数井裕光
  • Total Pages: 9
  • Publisher: 金芳堂