| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We investigated twice, 6 months apart, the effects of a cognitive remediation therapy, Neuropsychological Educational Approach to Cognitive Remediation (NEAR), on the cortical hemodynamic responses during two cognitive tasks in the patients with schizophrenia (N=19) using near-infrared spectroscopy (NIRS). NEAR significantly increased the working memory (WM)-related NIRS signal in three cortical regions including frontopolar and dorsolateral prefrontal cortices. There were also significant interactions between “treatment group” and “time” mainly in the forontopolar regions with the increase in the signals being significantly larger in the NEAR group than in the control patient group. In contrast, the verbal fluency-related NIRS signals were generally decreased after NEAR, making a striking difference with the results observed for WM task. These results indicate that NEAR can improve cognitive impairment in schizophrenia in a dynamic way dependent on the task involved.
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