• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Disrupted cortico-limbic network and molecular mechanism in bipolar disorder

Research Project

Project/Area Number 24591716
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionYamaguchi University

Principal Investigator

MATSUO Koji  山口大学, 医学(系)研究科(研究院), 准教授 (00292912)

Co-Investigator(Kenkyū-buntansha) YAMGATA Hirotaka  山口大学, 大学院医学系研究科, 助教 (10549934)
WATANUKI Toshio  山口大学, 医学部附属病院, 助教 (80610865)
MATSUBARA Toshio  山口大学, 医学部附属病院, 講師 (60526896)
UCHIDA Shusaku  山口大学, 医学部附属病院, 講師 (10403669)
OTSUKI Koji  山口大学, 大学院医学系研究科, 助教 (10535256)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords躁うつ病 / 神経画像 / 双極性障害 / 気分障害 / 脳体積 / 白質走行 / 遺伝子 / 脳画像
Outline of Final Research Achievements

Patients with bipolar disorder (BD) showed decreased frontal activation during emotional words with negative valence. They also showed increased high risk behaviors during a gambling task, which was not associated with gray matter volume of medial prefrontal cortex. Family study demonstrated that patients with BD had small gray matter volume of left insula and the patients and relatives of BD had small gray matter volume of left anterior cingulate.
Depressed patients with BD and depressed and remitted patients with MDD showed increased level of mRNA expression of hypoxia-inducible factor-1.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (24 results)

All 2015 2014 2013 2012

All Journal Article (10 results) (of which Peer Reviewed: 9 results,  Acknowledgement Compliant: 4 results,  Open Access: 1 results) Presentation (14 results)

  • [Journal Article] Blunted brain activation in patients with schizophrenia in response to emotional cognitive inhibition: A functional near-infrared spectroscopy study2015

    • Author(s)
      Egashira K, Matsuo K, Nakashima M, Watanuki T, Harada K, Nakano M, Matsubara T, Takahashi K, Watanabe Y
    • Journal Title

      Schizophrenia Research

      Volume: 162 Issue: 1-3 Pages: 196-204

    • DOI

      10.1016/j.schres.2014.12.038

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Different and shared brain volume abnormalities in late- and early-onset schizophrenia2014

    • Author(s)
      Egashira K, Matsuo K, Mihara T, Nakano M, Nakashima M, Watanuki T, Matsubara T, Watanabe Y
    • Journal Title

      Neuropsychobiology

      Volume: 70 Issue: 3 Pages: 142-151

    • DOI

      10.1159/000364827

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Common variants at 1p36 are associated with superior frontal gyrus volume.2014

    • Author(s)
      Hashimoto R, Ikeda M, Yamashita F, Ohi K, Yamamori H, Yasuda Y, Fujimoto M, Fukunaga M, Nemoto K, Takahashi T, Tochigi M, Onitsuka T, Yamasue H, Matsuo K, Iidaka T, Iwata N, Suzuki M, Takeda M, Kasai K, Ozaki N
    • Journal Title

      Translational Psychiatry

      Volume: 4 Issue: 10 Pages: e472-e472

    • DOI

      10.1038/tp.2014.110

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Reliability and validity assessment of the Japanese version of the confusion assessment method for the intensive care unit (CAM-ICU)2014

    • Author(s)
      Koga K, Tsuruta R, Murata H, Matsuo K, Ito T, Ely EW, Shintani A, Wakamatsu H, Sanui M, Yamase H
    • Journal Title

      Intensive and Critical Care Nursing

      Volume: 22

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prefrontal abnormality in children with ADHD during cognitive interference control: a functional NIRS study2014

    • Author(s)
      Nakashima M, Matsuo K, Hashimoto A, Nakano M, Fujii Y, Matsushige T, Egashira K, Matsubara T, Nishida A, Ichiyama T, Sugiyama S, Watanabe Y
    • Journal Title

      The Bulletin of Yamaguchi Medical School

      Volume: 61 Pages: 37-47

    • NAID

      120005593781

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Gray matter volume and rapid decision-making in major depressive disorder2014

    • Author(s)
      Nakano M, Matsuo K, Nakashima M, Matsubara T, Harada K, Egashira K, Masaki H, Takahashi K, Watanabe Y
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 48 Pages: 51-56

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prefrontal activation in response to emotional words in patients with bipolar disorder and major depressive disorder2014

    • Author(s)
      Matsubara T, Matsuo K, Nakashima M, Nakano M, Harada K, Watanuki T, Egashira K, Watanabe Y.
    • Journal Title

      NeuroImage

      Volume: 85 Pages: 489-497

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of the International Classification of Functioning, Disability and Health core sets for bipolar disorders: results of an international consensus process.2013

    • Author(s)
      Ayuso-Mateos JL, Avila CC, Anaya C, Cieza A, Vieta E; and the Bipolar Disorders Core Sets Expert Group
    • Journal Title

      Disabil Rehabil

      Volume: 35 Pages: 2138-2146

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A longitudinal study of fronto-limbic brain structures in patients with bipolar I disorder during lithium treatment2013

    • Author(s)
      Selek S, Nicoletti M, Zunta-Soares GB, Hatch JP, Nery FG, Matsuo K, Sanches M, Soares JC
    • Journal Title

      J Affect Disord

      Volume: 150 Pages: 629-633

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 情動認知課題におけるNIRS2013

    • Author(s)
      松尾幸治
    • Journal Title

      精神科診断学

      Volume: 6 Pages: 64-68

    • Related Report
      2013 Research-status Report
  • [Presentation] 寛解状態の気分障害患者における情動顔刺激に対する脳血流動態変化の検討2014

    • Author(s)
      松原敏郎、松尾幸治、原田健一郎、中島麻美、樋口尚子、樋口文宏、綿貫俊夫、芳原輝之、山形弘隆、渡邉義文
    • Organizer
      第36回日本生物学的精神医学会・第57回日本神経化学会合同年会
    • Place of Presentation
      奈良県文化会館、奈良市
    • Year and Date
      2014-09-29 – 2014-10-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 高齢うつ病の脳構造学的異常2014

    • Author(s)
      原田健一郎、松尾幸治、中島麻美、下地啓五、柴田朋彦、樋口文宏、樋口尚子、中野雅之、芳原輝之、大朏孝治、綿貫俊夫、山形弘隆、松原敏郎、上田克彦、古川又一、松永尚文、渡邉義文
    • Organizer
      第36回日本生物学的精神医学会・第57回日本神経化学会合同年会
    • Place of Presentation
      奈良県文化会館、奈良市
    • Year and Date
      2014-09-29 – 2014-10-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 統合失調症患者におけるface matching taskを用いたNIRS研究2014

    • Author(s)
      綿貫俊夫, 松尾幸治, 江頭一輝, 中島麻美, 原田健一郎, 平田圭子, 松原敏郎, 高橋幹治, 渡邉義文
    • Organizer
      第36回日本生物学的精神医学会・第57回日本神経化学会合同年会
    • Place of Presentation
      奈良県文化会館、奈良市
    • Year and Date
      2014-09-29 – 2014-10-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 高齢者うつ病における脳機能および深部白質以上の関連性の検討2014

    • Author(s)
      松原敏郎, 松尾幸治, 原田健一郎, 中島麻美, 樋口尚子, 樋口文宏, 綿貫俊夫, 芳原輝之, 山形弘隆, 渡邉義文
    • Organizer
      第11回日本うつ病学会総会
    • Place of Presentation
      広島国際会議場、広島市
    • Year and Date
      2014-07-18 – 2014-07-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Reduced hippocampal gray-matter volumes in patients with late-life depression2014

    • Author(s)
      Kenichiro Harada, Koji Matsuo, Mami Nakashima, Fumihiro Higuchi, Naoko Higuchi, Tomohiko Shibata, Masayuki Nakano, Koji Otsuki, Toshio Watanuki, Matakazu Furukawa, Hirotaka Yamagata, Toshio Matsubara, Naofumi Matsunaga, Yoshifumi Watanabe:
    • Organizer
      Society of Biological Psychiatry 69th Annual Meeting
    • Place of Presentation
      New York, USA
    • Year and Date
      2014-05-10 – 2014-05-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Morphometric abnormalities in unaffected first-degree relatives of mood disorders2014

    • Author(s)
      Toshio Matsubara, Koji Matsuo, Masayuki Nakano, Mami Nakashima, Toshio Watanuki, Kazuteru, Egashira, Matakazu Furukawa, Naofumi Matsunaga, Yoshifumi Watanabe
    • Organizer
      Society of Biological Psychiatry 69th Annual Meeting
    • Place of Presentation
      New York, USA
    • Year and Date
      2014-05-10 – 2014-05-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Neural correlates of rapid decision-making in patients with bipolar disorder.2013

    • Author(s)
      Harada K, Matsuo K, Nakano M, Nakashima M, Egashira K, Watanuki T, Matsubara T, Furukawa M, Matsunaga N, Watanabe Y
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto (Kyoto International Conference Center)
    • Related Report
      2013 Research-status Report
  • [Presentation] Brain hemodynamic responses during an emotional facial matching task in patients with schizophrenia2013

    • Author(s)
      Watanuki T, Matsuo K, Egashira K, Nakashima M, Nakano M, Harada K, Matsubara T, Takahashi K, Watanabe Y
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto (Kyoto International Conference Center)
    • Related Report
      2013 Research-status Report
  • [Presentation] Differential pattern of abnormal brain activation to emotional words in individuals with bipolar disorder and major depressive disorder in remission2013

    • Author(s)
      Matsubara T, Matsuo K, Nakashima M, Nakano M, Harada K, Watanuki T, Egashira K, Watanabe Y
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto (Kyoto International Conference Center)
    • Related Report
      2013 Research-status Report
  • [Presentation] A near-infrared spectroscopy study of brain hemodynamic response during a stop signal task in children with attention-deficit/hyperactivity disorder2013

    • Author(s)
      Nakashima M, Matsuo K, Hashimoto A, Nakano M, Fujii Y, Watanuki T, Matsushige T, Matsubara T, Sugiyama S, Ichiyama T, Watanabe Y
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto (Kyoto International Conference Center)
    • Related Report
      2013 Research-status Report
  • [Presentation] Blunted brain activation in schizophrenia during an emotional go/no-go task using functional multi-channel near-infrared spectroscopy2013

    • Author(s)
      Egashira K, Matsuo K, Nakashima M, Watanuki T, Harada K, Nakano M, Matsubara T, Takahashi K, Watanabe Y
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto (Kyoto International Conference Center)
    • Related Report
      2013 Research-status Report
  • [Presentation] 双極性障害患者における不確かな状況下での意思決定異常2012

    • Author(s)
      原田健一郎、松尾幸治、中野雅之、中島麻美、江頭一輝、綿貫俊夫、正木宏明、松原敏郎、渡邉義文
    • Organizer
      日本生物学的精神医学会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Related Report
      2012 Research-status Report
  • [Presentation] 健常人における情動語課題に対する脳血流動態の変化の検討2012

    • Author(s)
      松原敏郎、松尾幸治、原田健一郎、中島麻美、中野雅之、綿貫俊夫、渡邉義文
    • Organizer
      日本生物学的精神医学会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Related Report
      2012 Research-status Report
  • [Presentation] Gender difference in the brain hemodynamic responses during an emotional Go/NoGo task2012

    • Author(s)
      Toshio Watanuki, Koji Matsuo, Kazuteru Egashira, Mami Nakashima, Masayuki Nakano, Toshio Matsubara, Yoshifumi Watanabe
    • Organizer
      18th Annual Meeting of the Organization for Human Brain Mapping
    • Place of Presentation
      北京(中国)
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi