Disrupted cortico-limbic network and molecular mechanism in bipolar disorder
Project/Area Number |
24591716
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Yamaguchi University |
Principal Investigator |
MATSUO Koji 山口大学, 医学(系)研究科(研究院), 准教授 (00292912)
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Co-Investigator(Kenkyū-buntansha) |
YAMGATA Hirotaka 山口大学, 大学院医学系研究科, 助教 (10549934)
WATANUKI Toshio 山口大学, 医学部附属病院, 助教 (80610865)
MATSUBARA Toshio 山口大学, 医学部附属病院, 講師 (60526896)
UCHIDA Shusaku 山口大学, 医学部附属病院, 講師 (10403669)
OTSUKI Koji 山口大学, 大学院医学系研究科, 助教 (10535256)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 躁うつ病 / 神経画像 / 双極性障害 / 気分障害 / 脳体積 / 白質走行 / 遺伝子 / 脳画像 |
Outline of Final Research Achievements |
Patients with bipolar disorder (BD) showed decreased frontal activation during emotional words with negative valence. They also showed increased high risk behaviors during a gambling task, which was not associated with gray matter volume of medial prefrontal cortex. Family study demonstrated that patients with BD had small gray matter volume of left insula and the patients and relatives of BD had small gray matter volume of left anterior cingulate. Depressed patients with BD and depressed and remitted patients with MDD showed increased level of mRNA expression of hypoxia-inducible factor-1.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Common variants at 1p36 are associated with superior frontal gyrus volume.2014
Author(s)
Hashimoto R, Ikeda M, Yamashita F, Ohi K, Yamamori H, Yasuda Y, Fujimoto M, Fukunaga M, Nemoto K, Takahashi T, Tochigi M, Onitsuka T, Yamasue H, Matsuo K, Iidaka T, Iwata N, Suzuki M, Takeda M, Kasai K, Ozaki N
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Journal Title
Translational Psychiatry
Volume: 4
Issue: 10
Pages: e472-e472
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Prefrontal abnormality in children with ADHD during cognitive interference control: a functional NIRS study2014
Author(s)
Nakashima M, Matsuo K, Hashimoto A, Nakano M, Fujii Y, Matsushige T, Egashira K, Matsubara T, Nishida A, Ichiyama T, Sugiyama S, Watanabe Y
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Journal Title
The Bulletin of Yamaguchi Medical School
Volume: 61
Pages: 37-47
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Reduced hippocampal gray-matter volumes in patients with late-life depression2014
Author(s)
Kenichiro Harada, Koji Matsuo, Mami Nakashima, Fumihiro Higuchi, Naoko Higuchi, Tomohiko Shibata, Masayuki Nakano, Koji Otsuki, Toshio Watanuki, Matakazu Furukawa, Hirotaka Yamagata, Toshio Matsubara, Naofumi Matsunaga, Yoshifumi Watanabe:
Organizer
Society of Biological Psychiatry 69th Annual Meeting
Place of Presentation
New York, USA
Year and Date
2014-05-10 – 2014-05-13
Related Report
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[Presentation] Morphometric abnormalities in unaffected first-degree relatives of mood disorders2014
Author(s)
Toshio Matsubara, Koji Matsuo, Masayuki Nakano, Mami Nakashima, Toshio Watanuki, Kazuteru, Egashira, Matakazu Furukawa, Naofumi Matsunaga, Yoshifumi Watanabe
Organizer
Society of Biological Psychiatry 69th Annual Meeting
Place of Presentation
New York, USA
Year and Date
2014-05-10 – 2014-05-13
Related Report
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[Presentation] A near-infrared spectroscopy study of brain hemodynamic response during a stop signal task in children with attention-deficit/hyperactivity disorder2013
Author(s)
Nakashima M, Matsuo K, Hashimoto A, Nakano M, Fujii Y, Watanuki T, Matsushige T, Matsubara T, Sugiyama S, Ichiyama T, Watanabe Y
Organizer
11th World Congress of Biological Psychiatry
Place of Presentation
Kyoto (Kyoto International Conference Center)
Related Report
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