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Cross-sectional and prospective study of depressive symptoms and depression in the community: the Hisayama Study.

Research Project

Project/Area Number 24591720
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionKyushu University

Principal Investigator

OHARA Tomoyuki  九州大学, 医学(系)研究科(研究院), 助教 (20623630)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Daigo  九州大学, 大学院医学研究院, 助教 (10596828)
KANBA Shigenobu  九州大学, 大学院医学研究院, 教授 (50195187)
二宮 利治  九州大学, 医学(系)研究科(研究院), 教授 (30571765)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsうつ病 / 地域一般住民 / 認知症 / 時代的変化 / 危険因子 / ADL障害 / 地域一般高齢者
Outline of Final Research Achievements

To investigate the prevalence of late-life depressive symptoms and depression, a cross-sectional survey was conducted among Hisayama residents aged 65 years or older in 2012-2013. Among them, a total of 1904 residents consented to participate (participation rate 93.5%). The crude prevalence of depressive symptoms and depression were 17.4% and 3.5%, respectively.
The cross-sectional survey in 2005 showed that depressive symptoms were significantly associated with disability, and the age-adjusted odds ratio of depressive symptoms elevated along with the severity of disability (p for trend <0.01). In a prospective study of risk factors for depressive symptoms in Hisayama elder residents without depressive symptoms, the 7-year cumulative incidence of depressive symptoms was 12.9%, and the disability was a significant risk factor for the development of depressive symptoms (odds ratio: 2.99).

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (24 results)

All 2015 2014 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Acknowledgement Compliant: 4 results,  Open Access: 1 results) Presentation (7 results) (of which Invited: 6 results) Book (3 results) Remarks (6 results)

  • [Journal Article] Midlife and late-life smoking and risk of dementia in the community: the Hisayama Study2015

    • Author(s)
      Ohara T(1番目), et al.
    • Journal Title

      J Am Geriatr Soc

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A genome-wide association study of late-onset Alzheimer’s disease in a Japanese population.2015

    • Author(s)
      Ohara T(2番目), et al.
    • Journal Title

      Psychiatric Genetics

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Milk and dairy consumption and risk of dementia in an elderly Japanese population: the Hisayama Study.2014

    • Author(s)
      Ozawa M, Ohara T, Ninomiya T, Hata J, Yoshida D, Mukai N, Nagata M, Uchida K, Shirota T, Kitazono T, Kiyohara Y
    • Journal Title

      J Am Geriatr Soc

      Volume: 62 Issue: 7 Pages: 1224-1230

    • DOI

      10.1111/jgs.12887

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Altered expression of diabetes-related genes in Alzheimer's disease brains: the hisayama study2014

    • Author(s)
      Hokama M, Oka S, Leon J, Ninomiya T, Honda H, Sasaki K, Iwaki T, Ohara T, Sasaki T, LaFerla FM, Kiyohara Y, Nakabeppu Y
    • Journal Title

      Cereb Cortex

      Volume: 24 Issue: 9 Pages: 2476-2488

    • DOI

      10.1093/cercor/bht101

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Milk and dairy consumption and risk of dementia in an elderly Japanese population: the Hisayama Study.2014

    • Author(s)
      Ohara T(2番目), et al.
    • Journal Title

      J Am Geriatr Soc

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dietary patterns and risk of dementia in an elderly Japanese population: the Hisayama Study.2013

    • Author(s)
      Ozawa M, Ninomiya T, Ohara T, Doi Y, Uchida K, Shirota T, Yonemoto K, Kitazono T, Kiyohara Y.
    • Journal Title

      Am J Clin Nutr

      Volume: 97 Issue: 5 Pages: 1076-1082

    • DOI

      10.3945/ajcn.112.045575

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association study of susceptibility genes for late-onset Alzheimer’s disease in the Japanese population2012

    • Author(s)
      Ohara T (1番目), et al.
    • Journal Title

      Psychiatr Genet

      Volume: 22 Issue: 6 Pages: 290-293

    • DOI

      10.1097/ypg.0b013e3283586215

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Self-reported dietary intake of potassium, calcium, and magnesium and risk of dementia in the Japanese: the Hisayama Study2012

    • Author(s)
      Ozawa, M. Ninomiya, T. Ohara, T. Hirakawa, Y. Doi, Y. Hata, J. Uchida, K. Shirota, T. Kitazono, T. Kiyohara, Y.
    • Journal Title

      J Am Geriatr Soc

      Volume: 60 Issue: 8 Pages: 1515-1520

    • DOI

      10.1111/j.1532-5415.2012.04061.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Epidemiology of senile dementia in Japan.2015

    • Author(s)
      Ohara T, Kanba S.
    • Organizer
      5th World Congress of Asian Psychiatry
    • Place of Presentation
      福岡市
    • Year and Date
      2015-03-05
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 糖尿病と認知症の疫学:久山町研究2015

    • Author(s)
      小原知之、清原 裕
    • Organizer
      第49回糖尿病学の進歩
    • Place of Presentation
      岡山市
    • Year and Date
      2015-02-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Dietary patterns and risk of dementia in an elderly Japanese population: the Hisayama Study.2014

    • Author(s)
      Ohara T, Ninomiya T, Kiyohara Y.
    • Organizer
      14th Inernational College of Geriatric Psychoneuropharmacology
    • Place of Presentation
      つくば市
    • Year and Date
      2014-10-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 認知症の危険因子・防御因子2013

    • Author(s)
      小原知之、二宮利治、神庭重信、清原 裕
    • Organizer
      第109回日本精神神経学会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 地域高齢住民におけるうつ状態の実態:久山町研究2013

    • Author(s)
      小原知之、二宮利治、吉田大悟、清原 裕、神庭重信
    • Organizer
      第10回日本うつ病学会
    • Place of Presentation
      北九州国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] 久山町研究-生活習慣病と認知症2012

    • Author(s)
      小原知之、二宮利治、神庭重信、清原 裕
    • Organizer
      第31回日本認知症学会学術集会
    • Place of Presentation
      つくば国際会議場
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 糖尿病と脳血管性認知症:久山町研究2012

    • Author(s)
      小原知之、清原 裕
    • Organizer
      第27回日本糖尿病合併症学会
    • Place of Presentation
      アクロス福岡国際会議場
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] DSM-5を読み解く<他のパーソナリティ障害>2014

    • Author(s)
      小原知之
    • Total Pages
      317
    • Publisher
      中山書店
    • Related Report
      2014 Annual Research Report
  • [Book] 精神・神経の治療薬事典-専門医からのアドバイス 2014-20152013

    • Author(s)
      小原知之、他
    • Total Pages
      369
    • Publisher
      総合医学社
    • Related Report
      2013 Research-status Report
  • [Book] 気分障害の薬理・生化学-うつ病の脳内メカニズム研究:進歩と挑戦-2012

    • Author(s)
      小原知之、関田敦子、何幸子、神庭重信
    • Total Pages
      335
    • Publisher
      医薬ジャーナル社
    • Related Report
      2012 Research-status Report
  • [Remarks] 九州大学大学院医学研究院 精神病態医学

    • URL

      https://www.med.kyushu-u.ac.jp/psychiatry/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 九州大学大学院医学研究院 環境医学分野

    • URL

      http://www.envmed.med.kyushu-u.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 九州大学大学院医学研究院 精神病態医学

    • URL

      http://www.med.kyushu-u.ac.jp/psychiatry/

    • Related Report
      2013 Research-status Report
  • [Remarks] 九州大学大学院医学研究院 環境医学分野

    • URL

      http://www.med.kyushu-u.ac.jp/envmed/index.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 九州大学大学院医学研究院 環境医学分野

    • URL

      http://www.med.kyushu-u.ac.jp/envmed/index.html

    • Related Report
      2012 Research-status Report
  • [Remarks] 九州大学大学院医学研究院 精神病態医学

    • URL

      http://www.med.kyushu-u.ac.jp/psychiatry/

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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