Cross-sectional and prospective study of depressive symptoms and depression in the community: the Hisayama Study.

• Project/Area Number: 24591720
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kyushu University
• Principal Investigator: OHARA Tomoyuki 九州大学, 医学(系)研究科(研究院), 助教 (20623630)
• Co-Investigator(Kenkyū-buntansha): YOSHIDA Daigo 九州大学, 大学院医学研究院, 助教 (10596828) ; KANBA Shigenobu 九州大学, 大学院医学研究院, 教授 (50195187) ; 二宮 利治 九州大学, 医学(系)研究科(研究院), 教授 (30571765)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: うつ病 / 地域一般住民 / 認知症 / 時代的変化 / 危険因子 / ADL障害 / 地域一般高齢者

Outline of Final Research Achievements

To investigate the prevalence of late-life depressive symptoms and depression, a cross-sectional survey was conducted among Hisayama residents aged 65 years or older in 2012-2013. Among them, a total of 1904 residents consented to participate (participation rate 93.5%). The crude prevalence of depressive symptoms and depression were 17.4% and 3.5%, respectively.
The cross-sectional survey in 2005 showed that depressive symptoms were significantly associated with disability, and the age-adjusted odds ratio of depressive symptoms elevated along with the severity of disability (p for trend <0.01). In a prospective study of risk factors for depressive symptoms in Hisayama elder residents without depressive symptoms, the 7-year cumulative incidence of depressive symptoms was 12.9%, and the disability was a significant risk factor for the development of depressive symptoms (odds ratio: 2.99).

Research Products

• [Journal Article] Midlife and late-life smoking and risk of dementia in the community: the Hisayama Study (2015)
  • Author(s): Ohara T(1番目), et al.
  • Journal Title: J Am Geriatr Soc Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A genome-wide association study of late-onset Alzheimer’s disease in a Japanese population. (2015)
  • Author(s): Ohara T(2番目), et al.
  • Journal Title: Psychiatric Genetics Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Milk and dairy consumption and risk of dementia in an elderly Japanese population: the Hisayama Study. (2014)
  • Author(s): Ozawa M, Ohara T, Ninomiya T, Hata J, Yoshida D, Mukai N, Nagata M, Uchida K, Shirota T, Kitazono T, Kiyohara Y
  • Journal Title: J Am Geriatr Soc Volume: 62 Issue: 7 Pages: 1224-1230
  • DOI: 10.1111/jgs.12887
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Altered expression of diabetes-related genes in Alzheimer's disease brains: the hisayama study (2014)
  • Author(s): Hokama M, Oka S, Leon J, Ninomiya T, Honda H, Sasaki K, Iwaki T, Ohara T, Sasaki T, LaFerla FM, Kiyohara Y, Nakabeppu Y
  • Journal Title: Cereb Cortex Volume: 24 Issue: 9 Pages: 2476-2488
  • DOI: 10.1093/cercor/bht101
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Milk and dairy consumption and risk of dementia in an elderly Japanese population: the Hisayama Study. (2014)
  • Author(s): Ohara T（2番目）, et al.
  • Journal Title: J Am Geriatr Soc Volume: in press
  • Peer Reviewed
• [Journal Article] Dietary patterns and risk of dementia in an elderly Japanese population: the Hisayama Study. (2013)
  • Author(s): Ozawa M, Ninomiya T, Ohara T, Doi Y, Uchida K, Shirota T, Yonemoto K, Kitazono T, Kiyohara Y.
  • Journal Title: Am J Clin Nutr Volume: 97 Issue: 5 Pages: 1076-1082
  • DOI: 10.3945/ajcn.112.045575
  • Peer Reviewed
• [Journal Article] Association study of susceptibility genes for late-onset Alzheimer’s disease in the Japanese population (2012)
  • Author(s): Ohara T (1番目), et al.
  • Journal Title: Psychiatr Genet Volume: 22 Issue: 6 Pages: 290-293
  • DOI: 10.1097/ypg.0b013e3283586215
  • Peer Reviewed
• [Journal Article] Self-reported dietary intake of potassium, calcium, and magnesium and risk of dementia in the Japanese: the Hisayama Study (2012)
  • Author(s): Ozawa, M. Ninomiya, T. Ohara, T. Hirakawa, Y. Doi, Y. Hata, J. Uchida, K. Shirota, T. Kitazono, T. Kiyohara, Y.
  • Journal Title: J Am Geriatr Soc Volume: 60 Issue: 8 Pages: 1515-1520
  • DOI: 10.1111/j.1532-5415.2012.04061.x
  • Peer Reviewed
• [Presentation] Epidemiology of senile dementia in Japan. (2015)
  • Author(s): Ohara T, Kanba S.
  • Organizer: 5th World Congress of Asian Psychiatry
  • Place of Presentation: 福岡市
  • Year and Date: 2015-03-05
  • Invited
• [Presentation] 糖尿病と認知症の疫学：久山町研究 (2015)
  • Author(s): 小原知之、清原 裕
  • Organizer: 第49回糖尿病学の進歩
  • Place of Presentation: 岡山市
  • Year and Date: 2015-02-20
  • Invited
• [Presentation] Dietary patterns and risk of dementia in an elderly Japanese population: the Hisayama Study. (2014)
  • Author(s): Ohara T, Ninomiya T, Kiyohara Y.
  • Organizer: 14th Inernational College of Geriatric Psychoneuropharmacology
  • Place of Presentation: つくば市
  • Year and Date: 2014-10-04
  • Invited
• [Presentation] 認知症の危険因子・防御因子 (2013)
  • Author(s): 小原知之、二宮利治、神庭重信、清原 裕
  • Organizer: 第109回日本精神神経学会
  • Place of Presentation: 福岡国際会議場
  • Invited
• [Presentation] 地域高齢住民におけるうつ状態の実態：久山町研究 (2013)
  • Author(s): 小原知之、二宮利治、吉田大悟、清原 裕、神庭重信
  • Organizer: 第10回日本うつ病学会
  • Place of Presentation: 北九州国際会議場
• [Presentation] 久山町研究-生活習慣病と認知症 (2012)
  • Author(s): 小原知之、二宮利治、神庭重信、清原 裕
  • Organizer: 第31回日本認知症学会学術集会
  • Place of Presentation: つくば国際会議場
  • Invited
• [Presentation] 糖尿病と脳血管性認知症：久山町研究 (2012)
  • Author(s): 小原知之、清原 裕
  • Organizer: 第27回日本糖尿病合併症学会
  • Place of Presentation: アクロス福岡国際会議場
  • Invited
• [Book] DSM-5を読み解く＜他のパーソナリティ障害＞ (2014)
  • Author(s): 小原知之
  • Total Pages: 317
  • Publisher: 中山書店
• [Book] 精神・神経の治療薬事典-専門医からのアドバイス 2014-2015 (2013)
  • Author(s): 小原知之、他
  • Total Pages: 369
  • Publisher: 総合医学社
• [Book] 気分障害の薬理・生化学－うつ病の脳内メカニズム研究：進歩と挑戦- (2012)
  • Author(s): 小原知之、関田敦子、何幸子、神庭重信
  • Total Pages: 335
  • Publisher: 医薬ジャーナル社
• [Remarks] 九州大学大学院医学研究院 精神病態医学
  • URL: https://www.med.kyushu-u.ac.jp/psychiatry/
• [Remarks] 九州大学大学院医学研究院 環境医学分野
  • URL: http://www.envmed.med.kyushu-u.ac.jp/
• [Remarks] 九州大学大学院医学研究院 精神病態医学
  • URL: http://www.med.kyushu-u.ac.jp/psychiatry/
• [Remarks] 九州大学大学院医学研究院 環境医学分野
  • URL: http://www.med.kyushu-u.ac.jp/envmed/index.html
• [Remarks] 九州大学大学院医学研究院 環境医学分野
  • URL: http://www.med.kyushu-u.ac.jp/envmed/index.html
• [Remarks] 九州大学大学院医学研究院 精神病態医学
  • URL: http://www.med.kyushu-u.ac.jp/psychiatry/