| Project/Area Number |
24591726
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO NOZOMI 奈良県立医科大学, 医学部, 准教授 (70364057)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Keywords | 主観的認知障害 / 地域在住高齢者 / 経度認知障害 / 認知症 / 社会的サポート / メタボリック症候群 / アポリポプロテインE4 / 軽度認知障害 / 認知機能低下 / 抑うつ状態 / 残存歯数 |
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| Outline of Final Research Achievements |
Japanese community-dwelling older people (1316 men, 1318 women) without depression and cognitive decline, aged more than 65 years old, were followed up for 5 years. In baseline examination (2007-2008), the prevalence of subjective memory impairment (SCI) was 73.9%. Five years later, 45.8% had still suffered from SCI, 28.4% had improved normally, and 7.8% had been aware of SCI. Of cognitively normal people in the baseline, 9.5% had declined to MCI and 4.5% to dementia (MMSE < 24).SCI and metabolic syndrome did not affect cognitive decline during 5 year follow-up interval. To protect cognitive decline might live independently under less social support.
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