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Follow-up study on the non-transient cases with At-risk mental state (ARMS)

Research Project

Project/Area Number 24591732
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionToho University

Principal Investigator

MIZUNO Masafumi  東邦大学, 医学部, 教授 (80245589)

Co-Investigator(Kenkyū-buntansha) TSUJINO Naohisa  東邦大学, 医学部, 講師 (00459778)
NEMOTO Takahiro  東邦大学, 医学部, 准教授 (20296693)
Research Collaborator INOUE Naomi  
YOROZUYA Yuko  
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords精神病発症危険状態 / 精神病発症超ハイリスク / 移行例・非移行例 / 統合失調症 / 早期介入 / 精神病 / ARMS
Outline of Final Research Achievements

Objectives: To observe trajectories of symptoms and psychosocial functioning in patients at ultra-high risk (UHR) for psychosis as well as to investigate the psychosocial predictors of transition to psychosis.
Method: Twenty-two prospectively identified patients fulfilling UHR criteria were followed in one-year longitudinal study. Symptoms and psychosocial functioning were measured at the baseline and after one year follow-up.Result: Among the 15 patients who underwent follow-up evaluation, 6 subjects had converted to full-blown psychosis at one year, and 9 had not. There was a tendency for non-converters to have lower social-functioning at their baseline than the converters.Conclusion: The study suggests the need for treatment targeting not only the prevention of developing psychosis but also targeting the recovery of social-functioning. Further investigation of UHR patients should be considered with longer follow up duration.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (31 results)

All 2014 2013 2012 Other

All Journal Article (10 results) (of which Peer Reviewed: 6 results) Presentation (17 results) (of which Invited: 5 results) Book (4 results)

  • [Journal Article] 発症早期(発症直後)first episode とその後の維持治療2014

    • Author(s)
      辻野尚久、山口大樹、根本隆洋、水野雅文
    • Journal Title

      臨床精神薬理

      Volume: 17 Pages: 649-653

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 精神疾患の予防をめざして2014

    • Author(s)
      水野雅文
    • Journal Title

      日本精神神経学会雑誌

      Volume: 116 Pages: 539-539

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 統合失調症の早期診断・早期治療の意義と課題2014

    • Author(s)
      水野雅文 新村秀人
    • Journal Title

      精神科診断学

      Volume: 7 Pages: 77-81

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 思春期青年期に特化したデイケア(イルボスコ)での取り組みとその評価2014

    • Author(s)
      舩渡川智之、田中友紀、根本隆洋、井上直美、水野雅文
    • Journal Title

      デイケア研究

      Volume: 18 Pages: 50-57

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Long-term course of cognitive function in chronically hospitalized patients with schizophrenia transitioning to community-based living2014

    • Author(s)
      Nemoto T, Niimura H, Ryu Y, Sakuma K, Mizuno M
    • Journal Title

      Schizophrenia Research

      Volume: (印刷中) Issue: 1-3 Pages: 90-95

    • DOI

      10.1016/j.schres.2014.03.015

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-term efficacy and tolerability of perospirone for young help-seeking people at clinical high risk: a preliminary open trial.2013

    • Author(s)
      Tsujino N, Nemoto T, Morita K, Katagiri N, Ito S, Mizuno M.
    • Journal Title

      Clinical Psychopharmacology and Neuroscience

      Volume: 11 Issue: 3 Pages: 132-136

    • DOI

      10.9758/cpn.2013.11.3.132

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Whither the Attenuated Psychosis Syndrome?2012

    • Author(s)
      AR Yung, SW Woods, S Ruhrmann, M Mizuno, et al.
    • Journal Title

      Schizophr Bull

      Volume: 38 Issue: 6 Pages: 1130-1134

    • DOI

      10.1093/schbul/sbs108

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Early psychosis in Asia: Insights from Japan.2012

    • Author(s)
      Masafumi Mizuno, Takahiro Nemoto, Naohisa Tsujino, Tomoyuki Funatogawa, Kiyoaki Takeshi.
    • Journal Title

      Asian Journal of Psychiatry

      Volume: 5 Pages: 93-97

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] わが国における精神科医・精神科医療の実態把握に関する調査結果(その1):実数ならびに分布についての基礎資料2012

    • Author(s)
      水野雅文、稲垣中、藤原修一郎、榎戸芙佐子、辻野尚久、根本康、野崎昭子、小島卓也
    • Journal Title

      精神経誌

      Volume: 114 Pages: 1374-1384

    • NAID

      10031156515

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 早期介入の臨床倫理2012

    • Author(s)
      藤井千代、水野雅文
    • Journal Title

      臨床精神医学

      Volume: 41 Pages: 1387-1394

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] The fractional anisotropy of the white matter in an at-risk mental state for psychosis: the tract specific analysis.2014

    • Author(s)
      Junichi Saito, Takahiro Nemoto, Masaaki Hori, Naoyuki Katagiri, Naohisa Tsujino, Tomoyuki Funatogawa, Kiyoaki Takeshi, Masafumi Mizuno
    • Organizer
      9th International Conference on Early Psychosis.
    • Place of Presentation
      Keio Plaza Hotel, Tokyo, Japan
    • Year and Date
      2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Attitudes towards early psychosis in Japanese psychiatric professionals.2014

    • Author(s)
      Yoko Baba, Takahiro Nemoto, Naohisa Tsujino, Naoyuki Katagiri, Taiju Yamaguchi, Masafumi Mizuno
    • Organizer
      9th International Conference on Early Psychosis.
    • Place of Presentation
      Keio Plaza Hotel, Tokyo, Japan
    • Year and Date
      2014-11-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] The relationship between motivation, social anxiety, and social functioning in schizophrenia.2014

    • Author(s)
      Tobe M, Nemoto T, Aikawa S, Baba Y, Tsujino N, Mizuno M
    • Organizer
      9th International Conference on Early Psychosis.
    • Place of Presentation
      Keio Plaza Hotel, Tokyo, Japan
    • Year and Date
      2014-11-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Early intervention for ultra-high risk youth in Japan: Clinical practice in three leading centres.2014

    • Author(s)
      Masahiro Katsura, Naohisa Tsujino, Shimako Nishiyama, Yoko Baba, Noriyuki Ohmuro, Yuko Higuchi, Tsutomu Takahashi, Takahiro Nemoto, Hiroo Matsuoka, Michio Suzuki, Masafumi Mizuno, Kazunori Matsumoto
    • Organizer
      9th International Conference on Early Psychosis
    • Place of Presentation
      Keio Plaza Hotel, Tokyo, Japan
    • Year and Date
      2014-11-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Implementing early intervention in Japan: its challenges and difficulties.2014

    • Author(s)
      Masafumi Mizuno
    • Organizer
      9th International Conference on Early Psychosis
    • Place of Presentation
      Keio Plaza Hotel, Tokyo, Japan
    • Year and Date
      2014-11-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Longitudinal relationship between the change in corpus callosum (CC) volume and the changes in the sub-threshold psychotic symptoms in at risk mental state (ARMS)2014

    • Author(s)
      Naoyuki Katagiri, Takahiro Nemoto, Naohisa Tsujino, Junichi Saito, Masafumi Mizuno
    • Organizer
      9th International Conference on Early Psychosis.
    • Place of Presentation
      Keio Plaza Hotel, Tokyo, Japan
    • Year and Date
      2014-11-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Influence of Expressed Emotion on clinical status of At-Risk Mental State.2014

    • Author(s)
      Funatogawa T, Nemoto T, Saito J, Baba Y, Tobe M, Hasuya H, Takeshi K, Yamaguchi T, Katagiri N, Tsujino N, Niimura H, Mizuno M
    • Organizer
      9th International Conference on Early Psychosis.
    • Place of Presentation
      Keio Plaza Hotel, Tokyo, Japan
    • Year and Date
      2014-11-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Feasibility and effectiveness of cognitive behavioral therapy for Japanese patients at ultra-high risk for psychosis: a pilot study.2014

    • Author(s)
      Naomi Inoue, Naohisa TSujino, Miki Tobe, Kazunori Mastumoto, Takahiro Nemoto, Masafumi Mizuno.
    • Organizer
      9th International Conference on Early Psychosis.
    • Place of Presentation
      Keio Plaza Hotel, Tokyo, Japan
    • Year and Date
      2014-11-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Early intervention in psychosis in Japan and in Asia.2014

    • Author(s)
      Masafumi Mizuno
    • Organizer
      5e Congresso Nazional, AIPP
    • Place of Presentation
      Salerno, Italy
    • Year and Date
      2014-10-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Identifying comorbidities of patients at Ultra-High Risk for Psychosis using the Rorschach comprehensive system.2014

    • Author(s)
      Noami Inoue, Yuko Yorozuya, Masafumi Mizuno
    • Organizer
      XXI International Congress of Rorschach and Projective Methods.
    • Place of Presentation
      Istanbul, Turkey
    • Year and Date
      2014-07-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Social anxiety as a treatment target to improve social adjustment and quality of life in schizophrenia.2014

    • Author(s)
      Sayaka Aikawa, Takahiro Nemoto, Naohisa Tsujino, Yoko Baba, Yuko Yorozuya, Miki Tobe, Kiyoaki Takeshi, Taiju Yamaguchi, Naoyuki Katagiri, Masafumi Mizuno.
    • Organizer
      Schizophrenia International Research Society 2014.
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2014-04-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] The present status and prospects for social psychiatry, Present status and prospects for Social Psychiatry in Japan

    • Author(s)
      Mizuno M
    • Organizer
      World Association for Social Psychiatry Congress
    • Place of Presentation
      Lisbon(Portugal)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Integrated intervention for early psychosis in young adults in Tokyo- Youth clinic and youth day care center of Toho University Hospital.

    • Author(s)
      Mizuno M
    • Organizer
      Psychosis Symposium 2013 organised in conjunction with the Singapore Mental Health Conference.
    • Place of Presentation
      Singapore(Singapore)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] What are the needs-oriented interventions for at-risk mental state patients ?

    • Author(s)
      Mizuno M
    • Organizer
      Psychosis Symposium 2013 organised in conjunction with the Singapore Mental Health Conference.
    • Place of Presentation
      Singapore(Singapore)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Early intervention for first episode psychosis in Japan. Invited Symposium on improving functioning in schizophrenia.

    • Author(s)
      Masafumi Mizuno
    • Organizer
      The 3rd Asian Congress on Schizophrenia Research
    • Place of Presentation
      Bali, Indonesia
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Efficacy of a comprehensive treatment center for early psychosis in Japan: A 1-year follow-up study.

    • Author(s)
      T Nemoto, K Takeshi, T Funatogawa, M Tobe, Y Saito, M Takahashi, E Moritsugu, J Saito, N Katagiri, H Niimura, N Tsujino, M Mizuno
    • Organizer
      8th International Conference on Early Psychosis
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Longitudinal effects of perospirone in patients with at-risk mental state.

    • Author(s)
      Naohisa Tsujino, Shinya Ito, Keiko Morita, Taiju Yamaguchi, Nao Tohgi, Tomoyuki Funatogawa, Kiyoaki Takeshi, Takahiro Nemoto, Masafumi Mizuno
    • Organizer
      8th International Conference on Early Psychosis
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Research-status Report
  • [Book] 重症化させないための精神疾患の診方と対応2014

    • Author(s)
      水野雅文
    • Total Pages
      282
    • Publisher
      医学書院
    • Related Report
      2014 Annual Research Report
  • [Book] Early Psychosis Intervention. A Culturally Adaptive Clinical Guideline.2013

    • Author(s)
      Masafumi Mizuno, Takahiro Nemoto, Naohisa Tsujino
    • Total Pages
      381
    • Publisher
      Hong Kong University Press
    • Related Report
      2013 Research-status Report
  • [Book] これからの退院支援・地域移行2012

    • Author(s)
      水野雅文
    • Total Pages
      194
    • Publisher
      医学書院
    • Related Report
      2012 Research-status Report
  • [Book] 統合失調症第3巻2012

    • Author(s)
      舩渡川智之、根本隆洋、武士清昭、水野雅文
    • Total Pages
      115
    • Publisher
      医薬ジャーナル社
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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