| Project/Area Number |
24591736
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
NAKAMURA Jun 産業医科大学, 医学部, 教授 (40148804)
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| Co-Investigator(Kenkyū-buntansha) |
SUGITA Atsuko 産業医科大学, 医学部, 助教 (40421333)
HORI Hikaru 産業医科大学, 医学部, 助教 (50421334)
YOSHIMURA Reiji 産業医科大学, 医学部, 准教授 (90248568)
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| Co-Investigator(Renkei-kenkyūsha) |
IGATA Ryouhei 産業医科大学, 医学部, 産業医学修練医 (00739477)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 術後せん妄 / 前向き研究 / リエゾン精神医学 / BDNF / せん妄 / 介入研究 / 血中MHPG / 血中BDNF / サイトカイン |
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| Outline of Final Research Achievements |
We performed the prospective randomized control study regarding the efficacy of psychological intervention for preventing post-operative delirium, and also investigated the reliability and validity of the delirium rating scale (DRS-R-98) in Japanese version. Patients who operated in liver, bile duct, and pancreas disease were enrolled the study. The patients were randomized in two groups (intervention and non-intervention). The scores of the DRS-R-98, BMI value, plasma levels of catecholamine metabolites, BDNF, and cytokines were compared between the two groups. Higher age, lower BMI, were definitely associated with the occurrence of delirium. There was a tendency lower BDNF and higher MHPG at baseline were related with delirium. Brief psychological intervention could not prevent emerging delirium. The validity and the reliability of the DRS-R-98 were robust. From these findings into account, more intensive psychological intervention is necessary to prevent post-operative delirium.
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