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A prospective study on the pathophysiology and therapy of delirium

Research Project

Project/Area Number 24591736
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

NAKAMURA Jun  産業医科大学, 医学部, 教授 (40148804)

Co-Investigator(Kenkyū-buntansha) SUGITA Atsuko  産業医科大学, 医学部, 助教 (40421333)
HORI Hikaru  産業医科大学, 医学部, 助教 (50421334)
YOSHIMURA Reiji  産業医科大学, 医学部, 准教授 (90248568)
Co-Investigator(Renkei-kenkyūsha) IGATA Ryouhei  産業医科大学, 医学部, 産業医学修練医 (00739477)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords術後せん妄 / 前向き研究 / リエゾン精神医学 / BDNF / せん妄 / 介入研究 / 血中MHPG / 血中BDNF / サイトカイン
Outline of Final Research Achievements

We performed the prospective randomized control study regarding the efficacy of psychological intervention for preventing post-operative delirium, and also investigated the reliability and validity of the delirium rating scale (DRS-R-98) in Japanese version. Patients who operated in liver, bile duct, and pancreas disease were enrolled the study. The patients were randomized in two groups (intervention and non-intervention). The scores of the DRS-R-98, BMI value, plasma levels of catecholamine metabolites, BDNF, and cytokines were compared between the two groups. Higher age, lower BMI, were definitely associated with the occurrence of delirium. There was a tendency lower BDNF and higher MHPG at baseline were related with delirium. Brief psychological intervention could not prevent emerging delirium. The validity and the reliability of the DRS-R-98 were robust. From these findings into account, more intensive psychological intervention is necessary to prevent post-operative delirium.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (5 results)

All 2013

All Journal Article (5 results) (of which Peer Reviewed: 5 results)

  • [Journal Article] Serum brain-derived neurotrophic factor Levels at 6 months after remission are not associated with subsequent depressive episodes2013

    • Author(s)
      Yoshimura, R. ・Hori, H.・Sugita, A.・Nakano, W.・Katsuki, A.・Nakamura,J
    • Journal Title

      Journal of Clinical Psychopharmacology

      Volume: 33(1) Pages: 142-143

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Plasma catecholamine metabolite levels and the activities of psychiatric symptoms in systemic lupus erythematosus.2013

    • Author(s)
      Sugita, A. ・Yoshimura, R.・Hori, H.・Nakano, W.・Katsuki, A.・Saito, K.・Tanaka, Y.・Nakamura,J
    • Journal Title

      Human Psychopharmacology

      Volume: 28 Pages: 198-202

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Plasma levels of interleukin-6 and selective serotonin reuptake inhibitor response in patients with major2013

    • Author(s)
      Yoshimura, R. ・Hori, H.・Sugita, A.・Nakano, W.・Katsuki, A.・Atake, K.・Nakamura, J.
    • Journal Title

      Human Psychopharmacology

      Volume: 28 Issue: 5 Pages: 466-470

    • DOI

      10.1002/hup.2333

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Switching to antipsychotic monotherapy can improve attention and processing speed, and social activity in chronic schizophrenia patients2013

    • Author(s)
      Hori, H. ・Yoshimura, R.・Katsuki, A.・Sugita, A.・Atake, K.・Nakamura, J
    • Journal Title

      Journal of Psychiatric Research

      Volume: 47(12) Pages: 1843-1848

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] せん妄の病態生理はどこまでわかったか2013

    • Author(s)
      阿竹 聖和 ・吉村 玲児・中村 純
    • Journal Title

      精神科治療学

      Volume: 28(8) Pages: 991-997

    • Related Report
      2013 Research-status Report
    • Peer Reviewed

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Published: 2013-05-31   Modified: 2019-07-29  

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