The establishment of the objective indicator for the post-stroke depression

• Project/Area Number: 24591740
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Nara Medical University
• Principal Investigator: YASUNO Fumihiko 奈良県立医科大学, 医学部, 准教授 (60373388)
• Co-Investigator(Kenkyū-buntansha): MATSUYAMA Tomohiro 兵庫医科大学, 先端医学研究所神経再生部門, 教授 (10219529) ; TAGUCHI Akihiko (財)先端医療振興財団, 再生医療研究部, 部長 (10359276) ; SEKIYAMA Atsuo 大阪市立大学, 医学(系)研究科(研究院), 准教授 (30403702)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 脳梗塞 / MRI / 拡散テンソル画像 / 免疫炎症反応 / T細胞 / 脳梗塞後うつ病 / うつ病 / ＭＲＩ / Ｔ細胞

Outline of Final Research Achievements

We investigate the microstructure abnormalities in the stroke patients as the objective indicator for the post-stroke depression, using magnetic resonance diffusion tensor imaging. We also investigated the relationship between the lymphocyte subsets and the cerebral abnormalities. Participants were 18 patients with acute ischemic stroke and 22 healthy comparison subjects. Fractional anisotropy (FA) was decreased in the bilateral anterior limb of the internal capsule in stroke patients. During six months after the onset, there was significant increase of FA and its increase was associated with the reduction of depression scale score. Patients showed decreased circulated regulatory T lymphocytes (Treg), and the reduction was related to the decrease of FA. FA reduction was considered to cause the abnormality of frontal-subcortical circuits related to the depression. The prevention of the post-stroke depression was expected by targeting the role of Treg in brain tissue repair after stroke.

Research Products

• [Journal Article] Delayed atrophy in posterior cingulate cortex and apathy after stroke. (2015)
  • Author(s): MatsuokaMatsuoka K, Yasuno F, Taguchi A, Yamamoto A, Kajimoto K, Kazui H, Kudo T, Sekiyama A, Kitamura S, Kiuchi K, Kosaka J, Kishimoto T, Iida H, Nagatsuka K
  • Journal Title: Int J Geriatr Psychiatry Volume: 30 Issue: 6 Pages: 566-572
  • DOI: 10.1002/gps.4185
  • Peer Reviewed
• [Journal Article] A structural model of age, grey matter volumes, education, and personality traits. (2015)
  • Author(s): Kitamura S, Yasuno F, Yamamoto A, Kazui H, Kudo T, Matsuoka K, Kiuchi K, Kosaka J, Nagatsuka K, Iida H, Kishimoto T.
  • Journal Title: Psychogeriatrics. Volume: 15 Issue: 1 Pages: 1-8
  • DOI: 10.1111/psyg.12118
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Microstructural abnormality in white matter, regulatory T lymphocytes, and depressive symptoms after stroke. (2014)
  • Author(s): Yasuno F, Taguchi A, Yamamoto A, Kajimoto K, Kazui H, Kudo T, Kikuchi-Taura A, Sekiyama A, Kishimoto T, Iida H, Nagatsuka K.
  • Journal Title: Psychogeriatrics Volume: 14 Issue: 4 Pages: 213-21
  • DOI: 10.1111/psyg.12084
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Possible protective effect of regulatory T cells on white matter microstructural abnormalities in stroke patients. (2014)
  • Author(s): Yasuno F, Taguchi A, Kikuchi-Taura A, Yamamoto A, Kazui H, Kudo T, Sekiyama A, Kajimoto K, Soma T, Kishimoto T, Iida H, Nagatsuka K.
  • Journal Title: J Clin Cell Immunol. Volume: 5 Issue: 03 Pages: 1-8
  • DOI: 10.4172/2155-9899.1000221
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Microstructural changes of the nucleus accumbens due to increase of estradiol level during menstrual cycle contribute to recurrent manic episodes –A single case study. (2014)
  • Author(s): Matsuoka K, Yasuno F, Inoue M, et al.
  • Journal Title: Psychiatry Research, Neuroimaging Volume: 221 Issue: 2 Pages: 12-18
  • DOI: 10.1016/j.pscychresns.2013.11.006
  • Peer Reviewed
• [Journal Article] Microstructural abnormalities in white matter and their effect on depressive symptoms after stroke. (2014)
  • Author(s): Yasuno F, Taguchi A, Yamamoto A Kajimoto K, Kazui H, Sekiyama A, Matsuoka K, Kitamura S, Kiuchi K, Kosaka J, Kishimoto T, Iida H, Nagatsuka K
  • Journal Title: Psychiatry Res Volume: 223 Issue: 1 Pages: 9-14
  • DOI: 10.1016/j.pscychresns.2014.04.009
  • Peer Reviewed
• [Journal Article] Decision-making deficit of a patient with axonal damage after traumatic brain injury. (2014)
  • Author(s): Yasuno F, Matsuoka K, Kitamura S, et al.
  • Journal Title: Brain and Cognition Volume: 84 Issue: 1 Pages: 63-82
  • DOI: 10.1016/j.bandc.2013.11.005
  • Peer Reviewed
• [Journal Article] 脳梗塞と精神症状 (2013)
  • Author(s): 安野史彦
  • Journal Title: 奈良県医師学会年報 Volume: 26 Pages: 35-40
• [Journal Article] Longitudinal white matter changes in Alzheimer's disease: A tractography-based analysis study. (2013)
  • Author(s): Kitamura S, Kiuchi K, Taoka T, Hashimoto K, Ueda S, Yasuno F, Morikawa M, Kichikawa K, Kishimoto T.
  • Journal Title: Brain Res Volume: Epub ahead of print Pages: 0-0
  • DOI: 10.1016/j.brainres.2013.03.052
  • Peer Reviewed
• [Journal Article] Increased binding of peripheral benzodiazepine receptor in mild cognitive impairment-dementia converters measured by positron emission tomography with [11C]DAA1106 (2012)
  • Author(s): Yasuno F, et al.
  • Journal Title: Psychiatric Research Volume: 203 Issue: 1 Pages: 67-74
  • DOI: 10.1016/j.pscychresns.2011.08.013
  • Peer Reviewed
• [Journal Article] 機能的画像(fMRI・PET)によるニューロリハの評価と展望 (2012)
  • Author(s): 安野史彦
  • Journal Title: 分子脳血管病 Volume: １１ Pages: 300-306
• [Journal Article] Glucocorticoid-induced TNF receptor-triggered T cells are key modulators for survival/death of neural stem/progenitor cells induced by ischemic stroke (2011)
  • Author(s): Takata M, Nakagomi T, Kashiwamura S, Taguchi A, Matsuyama T
  • Journal Title: Cell Death Differ Volume: 19 Issue: 5 Pages: 756-67
  • DOI: 10.1038/cdd.2011.145
  • Peer Reviewed
• [Presentation] 脳卒中後うつ病の予防と治療 (2015)
  • Author(s): 安野史彦
  • Organizer: 第40回日本脳卒中学会
  • Place of Presentation: 広島
  • Year and Date: 2015-03-26
  • Invited
• [Presentation] 循環器疾患に伴ううつ病の予防：心理社会および生物学的観点から. (2014)
  • Author(s): 安野史彦
  • Organizer: 第18回日本精神保健・予防学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-11-13
  • Invited
• [Presentation] Microstructural abnormality in white matter, regulatory T lymphocytes and depressive symptoms after stroke. (2014)
  • Author(s): Yasuno F
  • Organizer: 14th International College of Geriatric Psychoneuropharmacology,
  • Place of Presentation: Tsukuba
  • Year and Date: 2014-10-03
• [Presentation] 脳梗塞後うつ病患者における脳白質微小構造ならびに制御性T細胞数の検討. (2014)
  • Author(s): 安野史彦
  • Organizer: 第110回日本精神神経学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-06-26
  • Invited
• [Presentation] Microstructural abnormality in white matter, regulatory T lymphocytes and depressive symptoms after stroke. (2014)
  • Author(s): Yasuno F, Iida H, Nagatsuka K
  • Organizer: 9th Japanese Society for Molecular Imaging.
  • Place of Presentation: Suita
  • Year and Date: 2014-05-23
• [Presentation] Hyperactivity of nucleus accumbens due to increase of estradiol level during menstrual cycle contributes to recurrent manic episodes: a case report. (2013)
  • Author(s): Matsuoka K, Yasuno F, Inoue M, et al.
  • Organizer: The 11th World Federation of Societies of Biological Psychiatry (WFSBP)
  • Place of Presentation: Kyoto
• [Presentation] Microstructural abnormality in white matter, regulatory T lymphocytes and depressive symptoms after stroke. (2013)
  • Author(s): Yasuno F, Taguchi A, Yamamoto A, et al.
  • Organizer: The 11th World Federation of Societies of Biological Psychiatry (WFSBP)
  • Place of Presentation: Kyoto
• [Presentation] 気分障害と脳梗塞後うつ病の拡散テンソル画像（DTI） (2013)
  • Author(s): 安野史彦
  • Organizer: 第10回日本うつ病学会
  • Place of Presentation: 北九州
  • Invited
• [Presentation] 気分障害と脳梗塞後うつ病の拡散テンソル画像（DTI） (2013)
  • Author(s): 安野史彦
  • Organizer: 第33回精神科診断学会
  • Place of Presentation: 近江
  • Invited
• [Presentation] 代表的な認知症疾患のMRI、SPECT画像
  • Author(s): 安野史彦
  • Organizer: 第31回日本認知症学会
  • Place of Presentation: 筑波
  • Invited
• [Book] 心血管系疾患患者に対する心身医学的アプローチ (2014)
  • Author(s): 安野史彦
  • Publisher: 南江堂
• [Book] 心血管系疾患患者に対する心身医学的アプローチ. (2014)
  • Author(s): 安野史彦
  • Publisher: 南江堂
• [Book] 内科患者のメンタルケアアプローチ 循環器疾患編 (2013)
  • Author(s): 安野史彦
  • Publisher: 新興医学出版社