| Project/Area Number |
24591740
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUYAMA Tomohiro 兵庫医科大学, 先端医学研究所神経再生部門, 教授 (10219529)
TAGUCHI Akihiko (財)先端医療振興財団, 再生医療研究部, 部長 (10359276)
SEKIYAMA Atsuo 大阪市立大学, 医学(系)研究科(研究院), 准教授 (30403702)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 脳梗塞 / MRI / 拡散テンソル画像 / 免疫炎症反応 / T細胞 / 脳梗塞後うつ病 / うつ病 / ＭＲＩ / Ｔ細胞 |
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| Outline of Final Research Achievements |
We investigate the microstructure abnormalities in the stroke patients as the objective indicator for the post-stroke depression, using magnetic resonance diffusion tensor imaging. We also investigated the relationship between the lymphocyte subsets and the cerebral abnormalities. Participants were 18 patients with acute ischemic stroke and 22 healthy comparison subjects. Fractional anisotropy (FA) was decreased in the bilateral anterior limb of the internal capsule in stroke patients. During six months after the onset, there was significant increase of FA and its increase was associated with the reduction of depression scale score. Patients showed decreased circulated regulatory T lymphocytes (Treg), and the reduction was related to the decrease of FA. FA reduction was considered to cause the abnormality of frontal-subcortical circuits related to the depression. The prevention of the post-stroke depression was expected by targeting the role of Treg in brain tissue repair after stroke.
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