Serotonin transporter dysfunction after traumatic brain injury.

• Project/Area Number: 24591741
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: HATTORI Naoya 北海道大学, 医学(系)研究科(研究院), 特任准教授 (30568499)
• Co-Investigator(Kenkyū-buntansha): IKOMA Kazunori 北海道大学, 大学院医学研究科, 教授 (70202918) ; SHIGA Tohru 北海道大学, 大学院医学研究科, 准教授 (80374495)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 頭部外傷 / セロトニントランスポーター / ポジトロンCT / 脳血流SPECT / 高次脳機能障害 / セロトニントランスポータ / 定量解析 / リハビリテーション / ポジトロン CT

Outline of Final Research Achievements

Serotonin transporter dysfunction may explain higher cognitive dysfunction after traumatic brain injury. We investigated cerebral serotonin transporter binding potential using modern positron-emission tomography and C-11 DASB, to compare cerebral blood flow using I-123 IMP SPECT. The quantitative analysis of C-11 DASB requires 90 min dynamic acquisition which might limit the use of this technique for the patients with higher cognitive dysfunction. On the other hand, I-123 IMP SPECT demonstrated regional cerebral blood flow changes even in patients without anatomical damages. In addition, it also demonstrated recovery of cerebellar blood flow in chronic patients who were stable in cognitive dysfunction without recovery even with cognitive rehabilitation.