Comprehensive risk assessment by using myocardial flow reserve in patients with diastolic dysfunction
| Project/Area Number |
24591742
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
Naya Masanao 北海道大学, 大学病院, 講師 (20455637)
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| Co-Investigator(Kenkyū-buntansha) |
KINUGAWA SHINTARO 北海道大学, 大学院医学研究科, 講師 (60399871)
IWANO HIROYUKI 北海道大学, 北海道大学医院, 医員 (50622354)
MANABE NORIKO 北海道大学, 北海道大学病院, 講師 (70463742)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 心不全 / 心臓交感神経 / 心臓PET / PET / 拡張障害 / 心筋血流予備能 / MRI / 冠動脈疾患 / 循環器 |
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| Outline of Final Research Achievements |
The present study focused on the assessment of diastolic dysfunction in terms of cardiac PET in patients with heart failure. Understanding the mechanism of diastolic dysfunction can help develop new effective treatment and tailor-made therapy. Forty-one patients with heart failure and preserved ejection fraction were studied. Cardiac sympathetic function was evaluated by C11-HED PET. Cardiac sympathetic function in patients with moderate to severe diastolic dysfunction was significantly decreased than that in normal to mild function.
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Report
(5 results)
Research Products
(4 results)
