Comprehensive risk assessment by using myocardial flow reserve in patients with diastolic dysfunction

• Project/Area Number: 24591742
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: Naya Masanao 北海道大学, 大学病院, 講師 (20455637)
• Co-Investigator(Kenkyū-buntansha): KINUGAWA SHINTARO 北海道大学, 大学院医学研究科, 講師 (60399871) ; IWANO HIROYUKI 北海道大学, 北海道大学医院, 医員 (50622354) ; MANABE NORIKO 北海道大学, 北海道大学病院, 講師 (70463742)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 心不全 / 心臓交感神経 / 心臓PET / PET / 拡張障害 / 心筋血流予備能 / MRI / 冠動脈疾患 / 循環器

Outline of Final Research Achievements

The present study focused on the assessment of diastolic dysfunction in terms of cardiac PET in patients with heart failure. Understanding the mechanism of diastolic dysfunction can help develop new effective treatment and tailor-made therapy. Forty-one patients with heart failure and preserved ejection fraction were studied. Cardiac sympathetic function was evaluated by C11-HED PET. Cardiac sympathetic function in patients with moderate to severe diastolic dysfunction was significantly decreased than that in normal to mild function.

Research Products

• [Presentation] Impairment of myocardial sympathetic innervation and its heterogeneity are associated with diastolic dysfunction in patients with heart failure and preserved ejection fraction: C11-hydroxyephedrine PET study (2016)
  • Author(s): 相川忠夫、納谷昌直、富山勇樹、小原雅彦、真鍋治、孫田恵一、山田聡、玉木長良、筒井裕之
  • Organizer: 米国核医学会
  • Place of Presentation: サンディエゴコンベンションセンター（米国、サンディエゴ）
  • Year and Date: 2016-06-10
  • Int'l Joint Research
• [Presentation] Progression of Diastolic Dysfunction is Associated with Impaired Cardiac Sympathetic Innervation in Patients with Heart Failure with Preserved Ejection Fraction (2016)
  • Author(s): 相川忠夫、納谷昌直、真鍋徳子、真鍋治、小原雅彦、岩野裕幸、山田聡、玉木長良、筒井裕之
  • Organizer: 日本循環器学会総会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-03-18
• [Presentation] Quantification of per-vessel coronary flow reserve by 3T-MRI is feasible in patients with coronary artery disease (2015)
  • Author(s): 納谷昌直、富山勇輝、真鍋治、菊地穏香、竹内敬介、加藤知恵次、小原雅彦、玉木長良、真鍋徳子、筒井裕之
  • Organizer: 日本循環器学会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2015-04-23 – 2015-04-26
• [Presentation] Development of Scan Protocol and Equation to Estimate Myocardial Blood Flow by Using Dynamic 320-Row Multi-detector CT Scan
  • Author(s): Tomiyama Y, Naya M, Kikuchi Y, Oyama-Manabe N, Manabe O, Sasaki T, Tstusui H, Tamaki N, Katoh C;
  • Organizer: 第77回 日本循環器学会学術集会
  • Place of Presentation: パシフィコ横浜(横浜）