| Project/Area Number |
24591743
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHINAGA Keiichirou 北海道大学, 大学院医学研究科, 特任教授 (30435961)
MANABE Osamu 北海道大学, 大学院医学研究科, 助教 (40443957)
MANABE Noriko 北海道大学, 大学病院, 講師 (70463742)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 心筋血流 / MRI / PET / 虚血性心疾患 / 定量測定 / 心筋血流定量 / コンパートメントモデル解析 / ＭＲＩ |
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| Outline of Final Research Achievements |
We developed a method to quantify myocardial blood flow (MBF) using dynamic MRI (MBFMRI) at 3T and compare with 15O-water PET (MBFPET). Methods: Twenty healthy volunteers underwent MRI and 15O-water PET at rest and during ATP stress. A single-tissue compartment model was used to estimate the inflow rate (K1). We estimated the extraction fraction of Gd-DTPA using K1 and MBF obtained from 15O-water PET for the first 10 subjects. In addition, we compared MBFMRI of 10 patients with coronary artery disease with those of healthy subjects. Results: The mean resting and stress MBFMRI were 0.76±0.10 and 3.04±0.82 mL/min/g, respectively, and showed excellent correlation with the mean MBFPET (r=0.96, P<0.01). The mean stress MBFMRI was significantly lower for the patients (1.92±0.37) than for the healthy subjects (P<0.001). Conclusion: The use of dynamic perfusion MRI at 3T is useful for estimating MBF and can be applied for patients with coronary artery disease.
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