Quantification of myocardial blood flow with dynamic perfusion 3.0 Tesla MRI
Project/Area Number |
24591743
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
|
Research Institution | Hokkaido University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
YOSHINAGA Keiichirou 北海道大学, 大学院医学研究科, 特任教授 (30435961)
MANABE Osamu 北海道大学, 大学院医学研究科, 助教 (40443957)
MANABE Noriko 北海道大学, 大学病院, 講師 (70463742)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 心筋血流 / MRI / PET / 虚血性心疾患 / 定量測定 / 心筋血流定量 / コンパートメントモデル解析 / MRI |
Outline of Final Research Achievements |
We developed a method to quantify myocardial blood flow (MBF) using dynamic MRI (MBFMRI) at 3T and compare with 15O-water PET (MBFPET). Methods: Twenty healthy volunteers underwent MRI and 15O-water PET at rest and during ATP stress. A single-tissue compartment model was used to estimate the inflow rate (K1). We estimated the extraction fraction of Gd-DTPA using K1 and MBF obtained from 15O-water PET for the first 10 subjects. In addition, we compared MBFMRI of 10 patients with coronary artery disease with those of healthy subjects. Results: The mean resting and stress MBFMRI were 0.76±0.10 and 3.04±0.82 mL/min/g, respectively, and showed excellent correlation with the mean MBFPET (r=0.96, P<0.01). The mean stress MBFMRI was significantly lower for the patients (1.92±0.37) than for the healthy subjects (P<0.001). Conclusion: The use of dynamic perfusion MRI at 3T is useful for estimating MBF and can be applied for patients with coronary artery disease.
|
Report
(4 results)
Research Products
(9 results)
-
[Journal Article] Quantification of myocardial blood flow with dynamic perfusion 3.0 Tesla MRI: Validation with 15 o-water PET.2014
Author(s)
Tomiyama Y, Manabe O, Oyama-Manabe N, Naya M, Sugimori H, Hirata K, Mori Y, Tsutsui H, Kudo K, Tamaki N, Katoh C.
-
Journal Title
J Magn Reson Imaging.
Volume: Dec 30.
Issue: 3
Pages: 754-762
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
[Journal Article] Interrelation between myocardial oxidative metabolism and diastolic function in patients undergoing surgical ventricular reconstruction.2013
Author(s)
Chiba S, Naya M, Iwano H, Yoshinaga K, Katoh C, Manabe O, Yamada S, Wakasa S, Kubota S, Matsui Y, Tamaki N, Tsutsui H
-
Journal Title
Eur J Nucl Med Mol Imaging.
Volume: 40(3)
Pages: 349-355
Related Report
Peer Reviewed
-
[Journal Article] Quantification of regional myocardial blood flow estimation with three-dimensional dynamic rubidium-82 PET and modified spillover correction model2012
Author(s)
Katoh C, Yoshinaga K, Klein R, Kasai K, Tomiyama Y, Manabe O, Naya M, Sakakibara M, Tsutsui H, deKemp RA, Tamaki N.
-
Journal Title
J Nucl Cardiol.
Volume: 19(4)
Pages: 763-774
Related Report
Peer Reviewed
-
-
-
-
-