| Project/Area Number |
24591744
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
Masashi Tsuda 東北大学, 医学(系)研究科(研究院), 非常勤講師 (10312555)
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| Co-Investigator(Kenkyū-buntansha) |
SYUNJI Mugikura 東北大学, 大学病院, 准教授 (20375017)
MATSUURA Tomonori 東北大学, 大学病院, 助教 (50623188)
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| Co-Investigator(Renkei-kenkyūsha) |
HIROTA Morihisa 東北大学, 大学病院, 助教 (70400364)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | MRI / ASL法 / 膵機能 / 血流 / 3TMRI / ASL / 膵血流 / 定量解析 / ALS |
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| Outline of Final Research Achievements |
Magnetic resonance imaging with arterial spin labeling is a non-invasive approach to measure organ perfusion. The purpose of this study was to determine the feasibility of using quantitative magnetic resonance imaging (MRI) with non-invasive flow-sensitive alternating inversion recovery (FAIR) arterial spin labeling (ASL) technique to assess pancreas perfusion on 3.0 T MRI.
Perfusion imaging in two different parts of the pancreas undergone in 6 healthy volunteers (6 male, mean age 39 years, range 28-49 years).ASL perfusion was acquired in all volunteers and assessment of pancreatic tissue perfusion was possible. Mean perfusion values were 216 +/- 56 mL/100g/min in the head/body and 148 +/- 35 mL/100g/min in the tail of the pancreas.
The quantitative measurement of pancreas perfusion by MRI with FAIR ASL technique could provide a non-invasive method for monitoring the status of blood flow without requiring the administration of a contrast agent.
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