Optimization of voxel-based statistical analyses for amyloid PET of Alzheimer's disease

• Project/Area Number: 24591745
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: KANETA Tomohiro 東北大学, サイクロトロン・ラジオアイソトープセンター, 准教授 (50323019)
• Co-Investigator(Kenkyū-buntansha): OKAMURA Nobuyuki 東北大学, 医学(系)研究科(研究院), 准教授 (40361076)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: アミロイドイメージング / 統計画像解析 / PET / Alzheimer's disease / Amyloid / statistical analysis / 認知症 / アルツハイマー病 / 画像診断 / アミロイド / BF-227

Outline of Final Research Achievements

We performed voxel-based statistical analyses for amyloid PET with BF-227 using both SPM and 3D-SSP, and compared the results in order to explore the optimal methods for the analyses. Differences in results were seen in 24% of normal subjects, 45% of MCI patients, and 68% of AD patients. Errors were often seen in the results of anatomical standardization. The use of blood flow images for 3D-SSP, and scalping for SPM might enable to reduce errors.

Research Products

• [Journal Article] Pitfalls of voxel-based amyloid PET analyses for diagnosis of Alzheimer's disease: artifacts due to non-specific uptake in the white matter and the skull. (2014)
  • Author(s): Arai A, Kaneta T, Okamura N, Tashiro M, Iwata R, Takanami K, Fukuda H, Takahashi S, Yanai K, Kudo Y, Arai H.
  • Journal Title: Tohoku J Exp Med Volume: 234 Pages: 175-181
  • NAID: 130004694506
  • Peer Reviewed
• [Journal Article] Analysis of early phase [^(11)C]BF-227 PET , and its application for anatomical standardization of late-phase images for 3D-SSP analysis (2014)
  • Author(s): Kaneta T, Okamura N, Arai A, Takanami K, Furukawa K, Tashiro M, Furumoto S, Iwata R, Takahashi S, Arai H, Y anai K, Kudo Y
  • Journal Title: Jpn J Radiol Volume: 32 Issue: 3 Pages: 138-144
  • DOI: 10.1007/s11604-013-0276-7
  • NAID: 50009030775
  • Peer Reviewed / Open Access