Development of a low cost flexible module system for automatic PET tracer production

• Project/Area Number: 24591751
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: University of Fukui
• Principal Investigator: MORI Tetsuya 福井大学, 高エネルギー医学研究センター, 助教 (40397287)
• Co-Investigator(Renkei-kenkyūsha): KIYONO Yasushi 福井大学, 高エネルギー医学研究センター, 教授 (50305603) ; OKAZAWA Hidehiko 福井大学, 高エネルギー医学研究センター, 教授 (50360813) ; FUJIBAYASHI Yasuhisa 放射線医学総合研究所, 分子イメージング研究センター, センター長 (50165411)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: PET薬剤 / 自動合成 / 放射性薬剤 / 自動合成システム / エストロゲンレセプター / アンドロゲンレセプター / 薬剤開発 / 放射性診断薬 / PET

Outline of Final Research Achievements

Automated synthesizer is necessary for translational research of PET tracers because it has advantages such as reproducibility production and workers exposure reduction. Most of the synthesizer is a high performance for clinical use, but is expensive. Therefore, we have designed a flexible module system at low cost for preclinical studies using commercially available servomotors for hobby robot kits. The system was realized to control plastic three-way valves, plastic syringes and I/O units for external devises. The layout of the modules were optimized for the synthesis of target tracers, and accomplished 4 tracers production. This flexible system can modify layout to suit the needs or preferences of the user. Therefore, the convenient system may help the research of the PET tracer development.

Research Products

• [Presentation] Development of a low cost multipurpose system for F-18 labeled PET probe synthesis (2015)
  • Author(s): Tetsuya Mori, Masaki Kunieda, Hidehiko Okazawa, Yasushi Kiyono
  • Organizer: Society of Nuclear Medicine and Molecular Imaging 2015 Annual Meeting
  • Place of Presentation: Baltimore, Maryland (USA)
  • Year and Date: 2015-06-06 – 2015-06-10
• [Presentation] Development of a low cost flexible module system for F-18 labeled PET tracer production (2014)
  • Author(s): Tetsuya Mori, Kenji Takaki, Yasuhisa Fujibayashi, Hidehiko Okazawa, Yasushi Kiyono
  • Organizer: Society of Nuclear Medicine and Molecular Imaging 2014 Annual Meeting
  • Place of Presentation: St.Louis, Missouri (USA)
  • Year and Date: 2014-06-07 – 2014-06-11
• [Presentation] 低価格高汎用性を目指したF-18標識薬剤自動合成システムの開発 (2014)
  • Author(s): 森 哲也、高木健志、近藤 篤彦、藤林靖久、岡沢秀彦、清野 泰
  • Organizer: 第9回日本分子イメージング学会総会・学術集会
  • Place of Presentation: 千里ライフサイエンスセンター（大阪府豊中市）
  • Year and Date: 2014-05-22 – 2014-05-23
• [Presentation] 低価格高汎用性を目指したＦ－１８標識薬剤自動合成システムの開発 (2014)
  • Author(s): 森 哲也、高木 健志、近藤 篤彦、藤林 靖久、岡沢 秀彦、清野 泰
  • Organizer: 第9回日本分子イメージング学会学術集会
  • Place of Presentation: 大阪府豊中市、千里ライフサイエンスセンター
• [Presentation] Development of a low cost flexible module system for F-18 labeled PET tracer production (2014)
  • Author(s): Tetsuya Mori, Kenji Takaki, Yasuhisa Fujibayashi, Hidehiko Okazawa, Yasushi Kiyono
  • Organizer: Society of Nuclear Medicine and Molecular Imaging 2014 Annual meeting
  • Place of Presentation: St. Louis Convention Center、St.Louis、MO、USA
• [Presentation] 汎用型PET薬剤自動合成システムの開発と実用性試験 (2013)
  • Author(s): 森 哲也, 高木 健志, 藤林 靖久, 岡沢 秀彦, 清野 泰
  • Organizer: 第53回日本核医学会学術総会
  • Place of Presentation: 福岡県福岡市、福岡国際会議場