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Development of the computer-aided analysis algorithm of hepatic contour abnormalities for the diagnosis of liver fibrosis

Research Project

Project/Area Number 24591752
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionGifu University

Principal Investigator

GOSHIMA Satoshi  岐阜大学, 医学部附属病院, 助教 (90402205)

Co-Investigator(Kenkyū-buntansha) KANEMATSU Masayuki  岐阜大学, 医学部附属病院, 准教授 (40252134)
KONDO Hiroshi  岐阜大学, 医学部附属病院, 講師 (20324311)
WATANABE Haruo  岐阜大学, 医学部附属病院, 医員 (30456529)
KAWADA Hiroshi  岐阜大学, 医学系研究科, 非常勤講師 (00585276)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords肝細胞癌 / 肝硬変症 / 肝線維化 / EOB造影MRI / 肝
Outline of Final Research Achievements

We have successfully applied a computer-aided analysis of hepatic contour that was highly accurate in diagnosing hepatic fibrosis stages F3 and F4. We also determined that the computer-generated, hepatic morphological index expressed as HFI was highly predictive for the development of hepatocellular carcinoma in patients with chronic hepatitis C. This index may serve as an important biomarker for clinical management of these patients.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (12 results)

All 2015 2014 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Invited: 4 results) Book (2 results)

  • [Journal Article] Computer-aided assessment of hepatic contour abnormalities as an imaging biomarker for the prediction of hepatocellular carcinoma development in patients with chronic hepatitis C2015

    • Author(s)
      Goshima S, Kanematsu M, Kondo H, Watanabe H, Noda Y, Fujita H, Bae KT
    • Journal Title

      Eur J Radiol

      Volume: 84 Issue: 5 Pages: 811

    • DOI

      10.1016/j.ejrad.2015.01.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] EOB造影MRIをさらに深く知る。Gd-EOB-DTPA造影MRIによる肝線維化の評価2013

    • Author(s)
      五島 聡
    • Journal Title

      日獨医報

      Volume: 58 Pages: 179-185

    • Related Report
      2013 Research-status Report
  • [Presentation] Computer-aided assessment of hepatic contour abnormalities as an imaging biomarker for the prediction of hepatocellular carcinoma development in patients with chronic hepatitis C.2014

    • Author(s)
      五島 聡、野田佳史、近藤浩史、棚橋裕吉、河合信行、渡邊春夫、兼松雅之、kyongtae T.Bae
    • Organizer
      第100回北米放射線学会
    • Place of Presentation
      シカゴ
    • Year and Date
      2014-11-30 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Computer-aided assessment of hepatic contour abnormalities as an imaging biomarker for the prediction of hepatocellular carcinoma development in patients with chronic hepatitis C.2014

    • Author(s)
      五島 聡、野田佳史、川田紘資、棚橋裕吉、近藤浩史、兼松雅之、Kyongtae T.Bae
    • Organizer
      第73回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-04-10 – 2014-04-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Computer-aided Assessment of Hepatic Contour Abnormalities as an Imaging Biomarker for the Prediction of HCC in Chronic Hepatitis C2014

    • Author(s)
      五島 聡
    • Organizer
      第73回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Latest Techniques of Abdominal Imaging MRI Assessment of Hepatic Fibrosis, HCC Development, and Therapeutic Efficacy2013

    • Author(s)
      五島 聡
    • Organizer
      Adcanced Imaging Multimodality Seminars, Abdominal Imaging. International Symposium
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] MRIによる肝線維化、肝細胞癌、治療効果の評価2013

    • Author(s)
      五島 聡
    • Organizer
      第4回マルチスライスCT学術講演会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Radiologic Prediction of Hepatic Fibrosis2013

    • Author(s)
      五島 聡
    • Organizer
      第72回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 肝腫瘤および肝線維化診断におけるEOB-MRIの有用性2012

    • Author(s)
      五島 聡
    • Organizer
      第7回肝癌シミュレーション研究会
    • Place of Presentation
      熊本
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Staging of Hepatic Fibrosis: Computer-aided Analysis of Hepatic Contours on Gd-EOB-DTPA-enhanced MR Imaging2012

    • Author(s)
      五島 聡、近藤浩史、渡邊春夫、川田紘資、兼松雅之
    • Organizer
      第71回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Book] 日独医報2013

    • Author(s)
      五島 聡
    • Total Pages
      8
    • Publisher
      バイエル薬品株式会社
    • Related Report
      2012 Research-status Report
  • [Book] 臨床画像2012

    • Author(s)
      五島 聡
    • Total Pages
      5
    • Publisher
      メジカルビュー社
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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