Evaluation of hepatic venous washout and fibrosis images by non-contrast MR venous perfusion image: Clinical feasibility and usefulness

• Project/Area Number: 24591755
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: ISODA Hiroyoshi 京都大学, 医学(系)研究科(研究院), 准教授 (20309214)
• Co-Investigator(Kenkyū-buntansha): TOGASHI Kaori 京都大学, 医学研究科, 教授 (90135484) ; TAURA Koujirou 京都大学, 医学研究科, 助教 (80378629)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 核磁気共鳴画像 / IVIM、 / 血流 / 肝移植 / 核磁気共鳴 / IVIM

Outline of Final Research Achievements

Our results in a series of normal volunteers showed that non-contrast-enhanced hepatic MR venous image could serve a noninvasive method of assessing hepatic venous washout. Non-contrast-enhanced hepatic MR portal perfusion image seems to be a reliable technique to evaluate hepatic venous washout.

Research Products

• [Journal Article] Non-contrast-enhanced MR portography and hepatic venography with time-spatial labeling inversion pulses: comparison of imaging with the short tau inversion recovery method and the chemical shift selective method. (2015)
  • Author(s): Shimizu H, Isoda H, Ohno T, Yamashita R, Kawahara S, Furuta A, Fujimoto K, Kido A, Togashi K.
  • Journal Title: Magn Reson Imaging Volume: 33 Issue: 1 Pages: 81-5
  • DOI: 10.1016/j.mri.2014.08.013
  • Peer Reviewed / Open Access
• [Journal Article] Perfusion in the tissue surrounding pancreatic cancer and the patient’s prognosis. (2014)
  • Author(s): Nishikawa Y, Tsuji Y, Isoda H, Kodama Y, Chiba T.
  • Journal Title: Journal of Biomed Res Int. Volume: 1 Pages: 1-6
  • DOI: 10.1155/2014/648021
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of monopolar and bipolar diffusion weighted imaging sequences for detection of small hepatic metastases. (2014)
  • Author(s): Furuta A, Isoda H, Yamashita R, Ohno T, Kawahara S, Shimizu H, Shibata T, Togashi K.
  • Journal Title: Eur. J Radiology Volume: 83 Issue: 9 Pages: 1626-1630
  • DOI: 10.1016/j.ejrad.2014.06.003
  • Peer Reviewed / Open Access
• [Journal Article] Non-Contrast-Enhanced MR Portography with Balanced Steady-State Free-Precession Sequence and Time-Spatial Labeling Inversion Pulses: (2014)
  • Author(s): Furuta A, Isoda H, Yamashita R, Ohno T, Kawahara S, Shimizu H, Fujimoto K, Kido A, Kusahara H, Togashi K.
  • Journal Title: J Magn Reson Imaging. Volume: 40 Issue: 3 Pages: 583-7
  • DOI: 10.1002/jmri.24427
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of acquired diffusion weighted imaging and computed diffusion weighted imaging for detection of hepatic metastases. (2013)
  • Author(s): Shimizu H, Isoda H, Fujimoto K, Kawahara S, Furuta A, Shibata T, Togashi K.
  • Journal Title: Eur. J Radiology Volume: 82 Issue: 3 Pages: 453-458
  • DOI: 10.1016/j.ejrad.2012.10.020
  • Peer Reviewed
• [Journal Article] Long-term Outcome of Percutaneous Interventions for Hepatic Venous Outflow Obstruction after Pediatric Living Donor Liver Transplantation: Experience from a Single Institute. (2013)
  • Author(s): Yabuta M, Shibata T, Shibata T, Shinozuka K, Isoda H, Okamoto S, Uemoto S, Togashi K.
  • Journal Title: Interv Radiol. Volume: 24 Issue: 11 Pages: 1673-1681
  • DOI: 10.1016/j.jvir.2013.07.010
  • Peer Reviewed
• [Presentation] Non-contrast-enhanced MR Arteriography with Balanced Steady-State Free-Precession Sequence and Time-Spatial Labeling Inversion Pulses: Comparison of Imaging with Flow-in and Modified Flow-out Methods. (2014)
  • Author(s): Isoda H, Furuta A, Yamashia R, Ohno T, Kawahara S, Shimizu H, Togashi K.
  • Organizer: 22th ISMRM
  • Place of Presentation: Milano
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] Visualization of pelvic splanchnic nerve using readout-segmented echo-planar diffusion-weighted imaging at 3T: preliminary experience in healthy male volunteers. (2014)
  • Author(s): Yamashia R, Isoda H, Furuta A, Kawahara S, Shimizu H, Ohno T, Kanao S, Murata K, Togashi K.
  • Organizer: 22th ISMRM
  • Place of Presentation: Milano
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] Long-term Outcome of Percutaneous Transhepatic Balloon Dilatation for Anastomotic Stricture at Roux-en-Y Hepaticojejunostomy after Pediatric Living Donor Liver Transplantation. (2013)
  • Author(s): Shibata T, Yabuta M, Shibata T, Isoda H, Togashi K.
  • Organizer: 99th RSNA
  • Place of Presentation: Chicago
• [Presentation] Long-term Outcome of Percutaneous Interventions of Hepatic Venous Outflow Obstruction after Pediatric Living Donor Liver Transplantation. (2013)
  • Author(s): Yabuta M, Shibata T, Shinozuka K, Shibata T, Isoda H, Togashi K.
  • Organizer: 99th RSNA
  • Place of Presentation: Chicago
• [Presentation] Sonazoid-CEUS during Radiofrequency (RFA) for Small Hepatocellular Carcinoma (HCC). (2013)
  • Author(s): Shibata T, Yabuta M, Shinozuka K, Shibata T, Isoda H, Togashi K.
  • Organizer: 99th RSNA
  • Place of Presentation: Chicago
• [Presentation] Advanced Techniques in Non-contrast-enhanced Hepatic MR Angiography. (2013)
  • Author(s): Isoda H, Shimizu H, Kawahara S, Ohno T, Yamashia R, Furuta A, Shibata T, Togashi K.
  • Organizer: 99th RSNA
  • Place of Presentation: Chicago
• [Presentation] Uptake-Positive Mass Lesions on Hepatobiliary Phase in Gadolinium -EOB-DTPA-enhanced MRI. (2012)
  • Author(s): Isoda H, Kawahara S, Shimizu H, Furuta A, Arizono S, Togashi K.
  • Organizer: 98th RSNA
  • Place of Presentation: Chicago
• [Presentation] Pitfalls in the Diagnosis of Liver Tumors in Patients with Severe Fatty Liver. (2012)
  • Author(s): Isoda H, Furuta A, Shimizu H, Kawahara S, Shibata T, Togashi K.
  • Organizer: 98th RSNA
  • Place of Presentation: Chicago
• [Presentation] Advanced Techniques in Upper Abdominal Diffusion-weighted MR Imaging. (2012)
  • Author(s): Isoda H, Shimizu H, Kawahara S, Furuta A, Shibata T, Togashi K.
  • Organizer: 98th RSNA
  • Place of Presentation: Chicago
• [Book] Abdominal Imaging. Computation and Clinical Applications. EPancreatic Blood Flow Measurements in the Pig Pancreatitis Model Using Perfusion CT with Deconvolution Method. (2014)
  • Author(s): Tsuji1 Y, Yamada K, Kisimoto M, Yazumi S, Isoda H, Chiba T.
  • Total Pages: 9
  • Publisher: Springer International Publishing