Diagnosis and risk stratification of breast lesions using DWI and automated color-coding

• Project/Area Number: 24591756
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: KATAOKA Masako 京都大学, 医学(系)研究科(研究院), 助教 (10611577)
• Research Collaborator: KANAO Shotaro , 放射線部, 助教 ; IIMA Mami , 画像診断・核医学講座, 学術振興会特別研究員 ; ONISHI Natsuko , 画像診断・核医学講座 ; KAWAI Makiko , 画像診断・核医学講座 ; OHASHI Akane , 画像診断・核医学講座
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: MRI / 拡散強調画像 / 乳癌 / ADC値 / 乳房 / DWI / 診断 / 乳腺 / カラーマップ

Outline of Final Research Achievements

We have published a paper showing the usefulness of DWI-derived parameters including ADC, IVIM and kurtosis in diagnosing malignant /benign breast lesions. We also established the computer program displaying each parameters and risk scores per each pixel fused with conventional MR image, presenting the utility of these color map in clinical diagnosis at the international meeting. In summary DWI-derived parameters and their color mapping are suggested as a useful tool in diagnosing and evaluating breast lesions.

Research Products

• [Journal Article] Quantitative Non-Gaussian Diffusion and Intravoxel Incoherent Motion Magnetic Resonance Imaging: Differentiation of Malignant and Benign Breast Lesions. (2015)
  • Author(s): Iima M, Yano K, Kataoka M, Umehana M, Murata K, Kanao S, Togashi K, Le Bihan D.
  • Journal Title: Investigative Radiology Volume: 50 Issue: 4 Pages: 205-211
  • DOI: 10.1097/rli.0000000000000094
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Detection of axillary lymph node metastasis with diffusion-weighted MR imaging (2014)
  • Author(s): Iima M, Kataoka M, Okumura R, Togashi K.
  • Journal Title: Clinical Imaging Volume: 38 Issue: 5 Pages: 633-636
  • DOI: 10.1016/j.clinimag.2014.04.016
  • Peer Reviewed
• [Journal Article] Apparent diffusion coefficient as a potential surrogate marker for Ki-67 index in mucinous breast carcinoma. (2014)
  • Author(s): Onishi N, Kanao S, Kataoka M, Iima M, Sakaguchi R, Kawai M, Kataoka T, Mikami Y, Toi M, Togashi K., et al.
  • Journal Title: Journal of Magnetic Resonance Imaging. Volume: (印刷中) Issue: 3 Pages: 24615-24615
  • DOI: 10.1002/jmri.24615
  • Peer Reviewed
• [Presentation] Non-Gaussian Diffusion MRI and Dynamic Contrast - Enhanced MRI in Evaluation of Early Treatment Effects During Neoadjuvant Chemotherapy for Breast Cancer (2014)
  • Author(s): Iima M, Kataoka M, Kanao S, Yano K, Umehana M, Ohashi A, Kawai M, Onishi N, Togashi K, Le Bihan D
  • Organizer: The 15th Asian Oceania Congress of Radiology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2014-09-24 – 2014-09-28
• [Presentation] IVIMと非ガウス拡散MRI - 癌診断におけるバイオマーカーとし ての可能性 (2014)
  • Author(s): 飯間麻美, デニスルビアン , 片岡正子 ,富樫かおり
  • Organizer: 第42回日本磁気共鳴医学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-09-18 – 2014-09-20
  • Invited
• [Presentation] Computer-assisted diagnosis of breast lesions based on IVIM and non Gaussian diffusion MRI (2014)
  • Author(s): Iima M, Kataoka M, Umehana M, Nakanishi Y, Ito T, Yano K, Kanao S, Togashi K. Le Bihan D
  • Organizer: The 22nd Annual Scientific Meeting and Exhibition of The International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Milan, Italy
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] Apparent diffusion coefficient as a potential surrogate marker for Ki-67 index in mucinous breast carcinoma: comparison with invasive carcinoma of no special type (2014)
  • Author(s): Onishi N, Kanao S, Kataoka M, iima M, Sakaguchi R, kawai M, Kataoka T, Mikami Y, Toi M, Togashi K.
  • Organizer: The 22nd Annual Scientific Meeting and Exhibition of The International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Milan, Italy
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] Computer-aided IVIM/Kurtosis Diffusion MRI for breast lesions: comparison with BIRADS MRI categories (2014)
  • Author(s): Iima M, Kataoka M, Nakanishi Y, Umehana M, Imakita T, Ito, Yano K, Kanao S, Togashi K, Le Bihan D
  • Organizer: European Congress of Radiology Vienna, 2014, March 6-10
  • Place of Presentation: Vienna
• [Presentation] Computer-assisted diagnosis of breast lesions based on IVIM and non Gaussian diffusion MRI (2014)
  • Author(s): Iima M, Kataoka M, Umehana M, Nakanishi Y, Ito T, Yano K, Kanao S, Togashi K. Le Bihan D.
  • Organizer: The 22 Annual Scientific Meeting and Exhibition of The International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Milan, Italy
• [Presentation] Apparent diffusion coefficient as a potential surrogate marker for Ki-67 index in mucinous breast carcinoma: comparison with invasive carcinoma of no special type (2014)
  • Author(s): Onishi N, Kanao S, Kataoka M, iima M, Sakaguchi R, kawai M, Kataoka T R, Mikami Y, Toi M, Togashi K
  • Organizer: The 22 Annual Scientific Meeting and Exhibition of The International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Milan, Italy
• [Presentation] Potential of perfusion imaging with IVIM MRI in breast cancer (2013)
  • Author(s): Iima M, Kataoka M, Le Bihan D, Umehana M, Imakita T, Nakagawa M, Kanao S, Yano K, Feiweier T, Togashi K
  • Organizer: The 21th Annual Scientific Meeting and Exhibition of The International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Salt lake City, USA
• [Presentation] Potential of perfusion imaging with IVIM MRI in breast cancer (2013)
  • Author(s): Iima M, Kataoka M, Le Bihan D, Umehana M, Imakita T, Nakagawa M, Kanao S, Yano K, Feiweier T, Togashi K
  • Organizer: The 21th Annual Scientific Meeting and Exhibition of The International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Salt Lake City, Utah, USA