Optimization and clinical application of double IR sequence for CNS diseases

• Project/Area Number: 24591757
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: KANAGAKI Mitsunori 京都大学, 医学(系)研究科(研究院), 助教 (50378676)
• Co-Investigator(Kenkyū-buntansha): OKADA Tomohisa 京都大学, 医学研究科, 講師 (30321607) ; YAMAMOTO Akira 京都大学, 医学研究科, 助教 (60525567)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: MRI / てんかん / FDG-PET

Outline of Final Research Achievements

Double IR sequence was optimized and tested on 3T MR. Double IR was the most sensitive sequence for detecting seizure focus laterality in temporal lobe epilepsy among the 2D and 3D sequences tested. Double IR was also shown to have high-detection ability for seizure focus laterality in temporal lobe epilepsy using VBA compared with FDG-PET. An important finding was that the laterality of increased signal intensity areas in the white matter on double IR located concordantly with the hypometabolic areas on FDG-PET.

Research Products

• [Journal Article] 頭部画像診断のPitfall 典型的所見の裏を読む 多発性硬化症 (2014)
  • Author(s): 金柿 光憲
  • Journal Title: 臨床画像 Volume: 30 Pages: 1246-1256
• [Journal Article] Evaluation of Focus Laterality in Temporal Lobe Epilepsy: A Quantitative Study Comparing Double Inversion-Recovery MR Imaging at 3T with FDG-PET. (2013)
  • Author(s): Morimoto E, Okada T, Kanagaki M, Yamamoto A, Fushimi Y, Matsumoto R, Takaya S, Ikeda A, Kunieda T, Kikuchi T, Paul D, Miyamoto S, Takahashi R, Togashi K.
  • Journal Title: Epilepsia Volume: 54 Issue: 12 Pages: 2174-83
  • DOI: 10.1111/epi.12396
  • Peer Reviewed
• [Journal Article] Fat-Water Interface on Susceptibility Weighted Imaging and Gradient Echo Imaging: A Comparison of Phantoms to Intracranial Lipomas (2013)
  • Author(s): Taha M. Mehemed, Akira Yamamoto, Tomohisa Okada, Mitsunori Kanagaki, Yasutaka Fushimi, Takeshi Sawada, Kaori Togashi
  • Journal Title: American Journal of Roentgenology Volume: 201(4): Issue: 4 Pages: 902-907
  • DOI: 10.2214/ajr.12.10049
  • Peer Reviewed
• [Journal Article] Visualization of Lenticulostriate Arteries by Flow-Sensitive Black-Blood MR Angiography on a 1.5T MRI System: A Comparative Study between Subjects with and without Stroke. AJNR Am J Neuroradiol. (2013)
  • Author(s): Okuchi S
  • Journal Title: AJNR Am J Neuroradiol Volume: 34 Issue: 4 Pages: 780-784
  • DOI: 10.3174/ajnr.a3310
  • Peer Reviewed
• [Journal Article] Anterior temporal lobe white matter abnormal signal (ATLAS) as an indicator of seizure focus laterality in temporal lobe epilepsy: comparison of double inversion-recovery, FLAIR and T2W MR imaging (2012)
  • Author(s): Morimoto E, Kanagaki M, Okada T, Yamamoto A, Mori N, Matsumoto R, Ikeda A, Mikuni N, Kunieda T, Paul D, Miyamoto S, Takahashi R, Togashi K
  • Journal Title: Eur Radiol Volume: 23 Issue: 1 Pages: 3-11
  • DOI: 10.1007/s00330-012-2565-4
  • Peer Reviewed
• [Presentation] 側頭葉てんかんにおける発作焦点側の同定: 3T MRIでのDIR法とFDG-PET法との比較 (2014)
  • Author(s): 森本笑子、岡田知久、金柿光憲、山本憲、伏見育崇、松本理器、池田昭夫、國枝武治、Dominik Paul、宮本享、高橋良輔、富樫かおり
  • Organizer: 第43回日本神経放射線学会
  • Place of Presentation: 米子市
• [Presentation] Evaluation of Focus Laterality in Temporal Lobe Epilepsy: A Quantitative Study Comparing Double Inversion-recovery MR Imaging at 3T with FDG-PET (2013)
  • Author(s): Morimoto E, Okada T, Kanagaki M, Yamamoto A, Fushimi Y, Matsumoto R, Takaya S, Ikeda A, Kunieda T, Kikuchi T, Paul D, Miyamoto S, Takahashi R, Togashi K
  • Organizer: Radiological Society of North America (RSNA) 99th Scientific Assembly and Annual Meeting
  • Place of Presentation: Chicago, USA
• [Presentation] 側頭葉てんかん焦点の同定における前側頭葉白質高信号(ATLAS)の有用性:DIR, FLAIR, T2WIでの比較 (2013)
  • Author(s): 森本 笑子、金柿 光憲、岡田 知久、山本 憲、森 暢幸、松本 理器、池田 昭夫、國枝 武治、Paul Dominik、宮本 亨、高橋 良輔、富樫 かおり
  • Organizer: 第42回日本神経放射線学会
  • Place of Presentation: 北九州国際会議場