| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Glial energy metabolism in both type 1 and type 2 diabetic model mouse brain was measured with 14C-acetate. 14C-acetate uptake was significantly increased in diabetic model mouse brain. 18F-FDG, a glucose analog, uptake at 1 minute and 30 minutes after 18F-FDG injection was decreased. 18F-FDG uptake (30 minutes) was more sensitive, and it shows that phosphorylation process by hexokinase is more sensitive than transport process by glucose transporters. In type 2 diabetic model brain, 14C-lactate uptake was significantly increased. It is suggested the possibility that energy substrates shifted to alternative one, such as monocarboxylates in diabetic model mouse brain.
In vivo muscarinic acetylcholine receptor binding using 3H-QNB was partly decreased. However, future study is required about receptor binding in diabetic model animal brain.
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