MRI-CFD combined analysis of brain aneurysm for initiation and growth factor of aneurysm
Project/Area Number |
24591760
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
|
Research Institution | Osaka University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
FUJINAKA Toshiyuki 大阪大学, 大学院医学研究科, 助教 (00359845)
WADA Shigeo 大阪大学, 基礎工学研究科, 教授 (70240546)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 脳動脈瘤 / 磁気共鳴画像 / 流体解析 / CFD / 計算流体力学 / MRI / 血流計側 / CFD解析 / MRA / 血流解析 / Phase-contrast |
Outline of Final Research Achievements |
We developed the new CFD analysis method using the 4D-PC-MRA flow data. Our CFD results were compared to the flow data by 4D-PC-MRA. Five unruptured cerebral aneurysms were included in this study. 3D-computational meshes were created from 3D-DSA images and CFD simulations were performed for two conditions: I= patient-specific inflow measured by 3D-PC MRA, II= patient-specific inflow and outflow measured by 3D-PC MRA. Difference in flow vector between CFD and PC-MRA was calculated at parent artery, aneurysm and distal arteries. The flow features such as vector map were similar between CFD and 4D-PC-MRA. There are no significant difference between condition I and II, but aneurysm showed statistically large flow difference compared to parent artery and distal arteries. Further study is needed to combine whole flow data of 4D-PC-MRA for CFD simulations.
|
Report
(4 results)
Research Products
(8 results)