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MRI-CFD combined analysis of brain aneurysm for initiation and growth factor of aneurysm

Research Project

Project/Area Number 24591760
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionOsaka University

Principal Investigator

WATANABE Yoshiyuki  大阪大学, 医学(系)研究科(研究院), 講師 (20362733)

Co-Investigator(Kenkyū-buntansha) FUJINAKA Toshiyuki  大阪大学, 大学院医学研究科, 助教 (00359845)
WADA Shigeo  大阪大学, 基礎工学研究科, 教授 (70240546)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords脳動脈瘤 / 磁気共鳴画像 / 流体解析 / CFD / 計算流体力学 / MRI / 血流計側 / CFD解析 / MRA / 血流解析 / Phase-contrast
Outline of Final Research Achievements

We developed the new CFD analysis method using the 4D-PC-MRA flow data. Our CFD results were compared to the flow data by 4D-PC-MRA. Five unruptured cerebral aneurysms were included in this study. 3D-computational meshes were created from 3D-DSA images and CFD simulations were performed for two conditions: I= patient-specific inflow measured by 3D-PC MRA, II= patient-specific inflow and outflow measured by 3D-PC MRA. Difference in flow vector between CFD and PC-MRA was calculated at parent artery, aneurysm and distal arteries. The flow features such as vector map were similar between CFD and 4D-PC-MRA. There are no significant difference between condition I and II, but aneurysm showed statistically large flow difference compared to parent artery and distal arteries. Further study is needed to combine whole flow data of 4D-PC-MRA for CFD simulations.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013 Other

All Journal Article (1 results) Presentation (7 results)

  • [Journal Article] 脳動脈瘤のMRA/MRI、CTA診断2014

    • Author(s)
      渡邉嘉之
    • Journal Title

      画像診断

      Volume: 34 Pages: 1409-1419

    • Related Report
      2014 Annual Research Report
  • [Presentation] 4D-Flow MRI for visualize the intracranial brain aneurysm hemodynamics2015

    • Author(s)
      渡邉嘉之
    • Organizer
      Annual meeting of american society of neuroradiology
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-05-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 4D-FLOW MRIを用いた脳動脈瘤内における血流動態の可視化2014

    • Author(s)
      渡邉 嘉之
    • Organizer
      第42回日本磁気共鳴医学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Comparison of flow characteristics of intracranial aneurysm between 4D-phase-contrast MR measurement and computational fluid dynamics simulations2014

    • Author(s)
      渡邉嘉之
    • Organizer
      Annual meeting of Korean Society of Neuroradiology and Head & Neck Radiology
    • Place of Presentation
      Incheon, Korea
    • Year and Date
      2014-04-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Comparison of flow characteristics of intracranial aneurysm between 4D-phase-contrast MR measurement and computational fluid dynamics simulations2014

    • Author(s)
      渡邉嘉之、國富裕樹、藤中俊之、 和田成生 他
    • Organizer
      KSNHNR Annual Meeting & NRF 2014
    • Place of Presentation
      Inchon, Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] 頭蓋内脳動脈瘤における4D-PC-MRAとCFD解析による速度データの比較2013

    • Author(s)
      渡邉嘉之、國富裕樹、藤中俊之、 和田成生 他
    • Organizer
      第41回日本磁気共鳴医学会大会
    • Place of Presentation
      徳島、
    • Related Report
      2013 Research-status Report
  • [Presentation] MRI-CFD融合解析を用いた脳血管血流動態解析の試み

    • Author(s)
      渡邉嘉之1、國富裕樹1 、田中壽1 、西澤光生1  塚部明生1 、富山憲幸1 、藤中俊之2網谷隼人3、大谷智仁3 、和田成生
    • Organizer
      第40回日本磁気共鳴医学会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] MRI-CFD融合解析を用いた脳動脈瘤血流動態解析:計測値による入力、出口条件設定

    • Author(s)
      渡邉嘉之1、國富裕樹1 、田中壽1 、西澤光生1  塚部明生1 、富山憲幸1 、藤中俊之2網谷隼人3、大谷智仁3 、和田成生
    • Organizer
      第42回日本神経放射線学会
    • Place of Presentation
      北九州
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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