Prediction of Therapeutic Effect by Quantitative Perfusion CT with Omics Information

• Project/Area Number: 24591762
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kobe University
• Principal Investigator: OHNO YOSHIHARU 神戸大学, 医学(系)研究科(研究院), 教授 (30324924)
• Co-Investigator(Kenkyū-buntansha): NISHIMURA Yoshihiro 神戸大学, 大学院医学研究科, 教授 (20291453) ; ITO Tomoo 神戸大学, 大学院医学研究科, 教授 (20301880) ; KOYAMA Hisanobu 神戸大学, 大学院医学研究科, 講師 (30546487) ; YOSHIKAWA Takeshi 神戸大学, 大学院医学研究科, 講師 (40332788) ; SUGIMURA Kazuro 神戸大学, 大学院医学研究科, 教授 (00136384) ; 眞庭 謙昌 神戸大学, 医学(系)研究科(研究院), 教授 (50362778) ; 竹中 大祐 神戸大学, 医学(系)研究科(研究院), 准教授 (60258233) ; 松本 純明 神戸大学, 医学(系)研究科(研究院), 准教授 (60397833) ; 西村 英輝 神戸大学, 医学(系)研究科(研究院), 准教授 (80444610) ; 小谷 義一 神戸大学, 医学(系)研究科(研究院), 講師 (90403287)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 放射線 / 生体機能利用 / Ｐｅｒｆｕｓｉｏｎ CT / Low-Dose / Lung Cancer / 灌流CT / 低線量 / 肺癌 / Perfusion CT / Quantitative Imaging / Lung cancer / 定量的画像解析

Outline of Final Research Achievements

The purpose of this study was to determine the utility of dynamic first-pass contrast-enhanced (CE-) perfusion area-detector CT (ADCT) and Omics information for prediction of therapeutic effect in lung cancer patients. During the study period, we determined the best protocolfor dynamic first-pass CE-perfusion ADCT, developed the software for quantitative assessment of perfusion parameters from dynamic first-pass perfusion ADCT data, and tried to obtain the associated information for the clinical purposes.

Research Products

• [Journal Article] Dynamic contrast-enhanced CT and MRI for pulmonary nodule assessment. (2014)
  • Author(s): Ohno Y, Nishio M, Koyama H, Miura S, Yoshikawa T, Matsumoto S, Sugimura K.
  • Journal Title: AJR Am J Roentgenol. Volume: 202 Issue: 3 Pages: 515-529
  • DOI: 10.2214/ajr.13.11888
  • Peer Reviewed
• [Journal Article] Comparison of quantitatively analyzed dynamic area-detector CT using various mathematic methods with FDG PET/CT in management of solitary pulmonary nodules. (2013)
  • Author(s): Ohno Y, Nishio M, Koyama H, Fujisawa Y, Yoshikawa T, Matsumoto S, Sugimura K.
  • Journal Title: AJR Am J Roentgenol. Volume: 200 Issue: 6 Pages: W593-W602
  • DOI: 10.2214/ajr.12.9197
  • Peer Reviewed
• [Journal Article] Analyzed Dynamic Area-Detector CT using Various Mathematical Methods with FDG-PET/CT in Management of Solitary Pulmonary Nodules (2013)
  • Author(s): Yoshiharu Ohno, Mizuho Nishio, Hisanobu Koyama, Yasuko Fujisawa, Takeshi Yoshikawa, Sumiaki Matsumoto, and Kazuro Sugimura
  • Journal Title: AJR Am J Roentgenol. Volume: -
  • Peer Reviewed
• [Presentation] Influence of Mathematical Model on Perfusion ADCT to Early Prediction of Recurrence in Non-Small Cell Lung Cancer Patients with Chemoradiotherapy (2015)
  • Author(s): Yosiharu Ohno, Shinichiro Seki, Hisanobu Koyama, Takeshi Yoshikawa, Sumiaki Matsumoto, Yasuko Fujisawa, Naoki Sugihara, Kazuro Sugimura
  • Organizer: ECR 2015
  • Place of Presentation: Vienna
  • Year and Date: 2015-03-04 – 2015-03-08
• [Presentation] Dynamic Contrast-enhanced Perfusion Area Detector CT in Non-small Cell Lung Cancer Patients: Influence of Mathematical Model to Early Prediction Capabilities for Treatment Response and Recurrence after Chemoradiotherapy (2014)
  • Author(s): Yosiharu Ohno, Shinichiro Seki, Mizuho Nishio, Hisanobu Koyama, Yasuko Fujisawa,Naoki Sugihara, Takeshi Yoshikawa,Sumiaki Matsumoto, Noriyuki Negi, Tohru Murakami, Takahara Nishitani, Kazuro Sugimura
  • Organizer: RSNA 2014
  • Place of Presentation: Chicago
  • Year and Date: 2014-11-30 – 2014-12-05
• [Presentation] Perfusion ADCT vs. Perfusion MRI vs. PET/CT for Pulmonary Nodule Assessment (2014)
  • Author(s): Yoshiharu Ohno, Yasuko Fujisawa, Naoki Sugihara
  • Organizer: 16th International Society of Computed Tomography
  • Place of Presentation: San Francisco
  • Year and Date: 2014-06-09 – 2014-06-12
  • Invited
• [Presentation] Dynamic First-Pass Pulmonary Perfusion Area-Detector CT for Lung Nodule Assessment: Comparison of Dose Reduction Capability between Adaptive Iterative Dose Reduction using 3D Processing and Filter Back Projection (2014)
  • Author(s): Yoshiharu Ohno, Shinichiro Seki, Mizuho Nishio, Hisanobu Koyama, Takeshi Yoshikawa, Sumiaki Matsumoto, Yasuko Fujisawa, Naoki Sugihara, Kazuro Sugimura
  • Organizer: ＥＣＲ 2014
  • Place of Presentation: Ｖｉｅｎｎａ
• [Presentation] Area-Detector CTの最新臨床応用と今後の展望 (2013)
  • Author(s): 大野良治
  • Organizer: 第72回日本医学放射線学会総会
  • Place of Presentation: 横浜
• [Presentation] Dynamic Perfusion ADCT vs. Dynamic Perfusion MRI vs. PET/CT: 肺結節鑑別診断能の比較 (2013)
  • Author(s): 大野良治，関 紳一郎，西尾瑞穂，神山久信，吉川 武，松本純明，杉村和朗
  • Organizer: 第72回日本医学放射線学会総会
  • Place of Presentation: 横浜
• [Presentation] Dynamic First-Pass Perfusion ADCT for Pulmonary Nodule Assessment: Comparison with Different Mathematical Methods and FDG-PET/CT (2013)
  • Author(s): Ｙｏｓｈｉｈａｒｕ Ｏｈｎｏ
  • Organizer: The Fleischner Society 2013 annual meeting
  • Place of Presentation: Jeju Island
• [Presentation] Pulmonary Perfusion Area-Detector CT: How to Decrease Radiation Dose and Apply in Routine Clinical Practice (2013)
  • Author(s): Ｙｏｓｈｉｈａｒｕ Ｏｈｎｏ
  • Organizer: 15ｔｈ Ａｎｎｕａｌ Ｍｅｅｔｉｎｇ ｏｆ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｓｏｃｉｅｔｙ ｏｆ Ｃｏｍｐｕｔｅｄ Ｔｏｍｏｇｒａｐｈｙ
  • Place of Presentation: Ｗａｓｈｉｎｇｔｏｎ ＤＣ
• [Presentation] Lung and Nodule Perfusion Assessments on Dynamic First-pass Perfusion Area-detector CT: Capability of Adaptive Iterative Dose Reduction Using 3D Processing (AIDR 3D) for Radiation Dose Reduction as Compared with Filter Back Projection (FBP) (2013)
  • Author(s): Yoshiharu Ohno, Mizuho Nishio, Takeshi Yoshikawa, Sumiaki Matsumoto, Yasuko Fujisawa, Naoki Sugihara, Hisanobu Koyama, Shinichiro Seki, Maho Tsubakimoto, Tohru Murakami, Masakazu Kanzawa, Kazuro Sugimura
  • Organizer: ＲＳＮＡ 2013
  • Place of Presentation: Ｃｈｉｃａｇｏ
• [Presentation] Comparison of Capabilities for Differentiating Malignant SPNs from Benign SPNs among Dynamic First-Pass Perfusion Area-Detector CT, Dynamic First-Pass MRI and FDG-PET/CT (2013)
  • Author(s): Yoshiharu Ohno, Shinichiro Seki, Mizuho Nishio, Hisanobu Koyama, Takeshi Yoshikawa, Sumiaki Matsumoto, Yasuko Fujisawa, Kazuro Sugimura
  • Organizer: ECR 2013
  • Place of Presentation: Vienna
• [Presentation] Dual-Input vs. Single-Input Perfusion CT vs. PET/CT: 肺結節鑑別診断能に関する検討 (2012)
  • Author(s): 大野良治，西尾瑞穂，尾西由美子，神山久信，吉川 武，竹中大祐，松本純明，藤澤恭子，杉村和朗
  • Organizer: 第71回日本医学放射線学会総会
  • Place of Presentation: 横浜
• [Presentation] 胸部CTにおける被曝低減：形態診断から機能診断へ (2012)
  • Author(s): 大野良治
  • Organizer: 第71回日本医学放射線学会総会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] Radiation Dose Reduction for CT Examinations: Basic Concept and New Techniques (2012)
  • Author(s): Yoshiharu Ohno
  • Organizer: 16th Workshop of the Japanese-German Radiological Affiliation
  • Place of Presentation: Munser
  • Invited
• [Presentation] First-Pass Perfusion Area-Detector CT: How to Analyze and Apply for Solitary Pulmonary Nodules (2012)
  • Author(s): Yoshiharu Ohno
  • Organizer: International Society for Computed Tomography 2012
  • Place of Presentation: San Francisco
  • Invited
• [Presentation] Dynamic First-Pass Perfusion Area-Detector CT Analyzed by Newly Developed and Previously Applied Methods vs Dynamic First-Pass MRI vs FDG-PET/CT: Differential Capability of Malignant SPN from Benign SPN (2012)
  • Author(s): Yoshiharu Ohno, Mizuho Nishio, Hisanobu Koyama, Takeshi Yoshikawa, Sumiaki Matsumoto, Yasuko Fujisawa, Naoki Sugihara, Shinichiro Seki, Masaru Yoshii, Kazuro Sugimura
  • Organizer: RSNA 2012
  • Place of Presentation: Chicago