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Prediction of Therapeutic Effect by Quantitative Perfusion CT with Omics Information

Research Project

Project/Area Number 24591762
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKobe University

Principal Investigator

OHNO YOSHIHARU  神戸大学, 医学(系)研究科(研究院), 教授 (30324924)

Co-Investigator(Kenkyū-buntansha) NISHIMURA Yoshihiro  神戸大学, 大学院医学研究科, 教授 (20291453)
ITO Tomoo  神戸大学, 大学院医学研究科, 教授 (20301880)
KOYAMA Hisanobu  神戸大学, 大学院医学研究科, 講師 (30546487)
YOSHIKAWA Takeshi  神戸大学, 大学院医学研究科, 講師 (40332788)
SUGIMURA Kazuro  神戸大学, 大学院医学研究科, 教授 (00136384)
眞庭 謙昌  神戸大学, 医学(系)研究科(研究院), 教授 (50362778)
竹中 大祐  神戸大学, 医学(系)研究科(研究院), 准教授 (60258233)
松本 純明  神戸大学, 医学(系)研究科(研究院), 准教授 (60397833)
西村 英輝  神戸大学, 医学(系)研究科(研究院), 准教授 (80444610)
小谷 義一  神戸大学, 医学(系)研究科(研究院), 講師 (90403287)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords放射線 / 生体機能利用 / Perfusion CT / Low-Dose / Lung Cancer / 灌流CT / 低線量 / 肺癌 / Perfusion CT / Quantitative Imaging / Lung cancer / 定量的画像解析
Outline of Final Research Achievements

The purpose of this study was to determine the utility of dynamic first-pass contrast-enhanced (CE-) perfusion area-detector CT (ADCT) and Omics information for prediction of therapeutic effect in lung cancer patients. During the study period, we determined the best protocolfor dynamic first-pass CE-perfusion ADCT, developed the software for quantitative assessment of perfusion parameters from dynamic first-pass perfusion ADCT data, and tried to obtain the associated information for the clinical purposes.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (18 results)

All 2015 2014 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (15 results) (of which Invited: 4 results)

  • [Journal Article] Dynamic contrast-enhanced CT and MRI for pulmonary nodule assessment.2014

    • Author(s)
      Ohno Y, Nishio M, Koyama H, Miura S, Yoshikawa T, Matsumoto S, Sugimura K.
    • Journal Title

      AJR Am J Roentgenol.

      Volume: 202 Issue: 3 Pages: 515-529

    • DOI

      10.2214/ajr.13.11888

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of quantitatively analyzed dynamic area-detector CT using various mathematic methods with FDG PET/CT in management of solitary pulmonary nodules.2013

    • Author(s)
      Ohno Y, Nishio M, Koyama H, Fujisawa Y, Yoshikawa T, Matsumoto S, Sugimura K.
    • Journal Title

      AJR Am J Roentgenol.

      Volume: 200 Issue: 6 Pages: W593-W602

    • DOI

      10.2214/ajr.12.9197

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analyzed Dynamic Area-Detector CT using Various Mathematical Methods with FDG-PET/CT in Management of Solitary Pulmonary Nodules2013

    • Author(s)
      Yoshiharu Ohno, Mizuho Nishio, Hisanobu Koyama, Yasuko Fujisawa, Takeshi Yoshikawa, Sumiaki Matsumoto, and Kazuro Sugimura
    • Journal Title

      AJR Am J Roentgenol.

      Volume: -

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Influence of Mathematical Model on Perfusion ADCT to Early Prediction of Recurrence in Non-Small Cell Lung Cancer Patients with Chemoradiotherapy2015

    • Author(s)
      Yosiharu Ohno, Shinichiro Seki, Hisanobu Koyama, Takeshi Yoshikawa, Sumiaki Matsumoto, Yasuko Fujisawa, Naoki Sugihara, Kazuro Sugimura
    • Organizer
      ECR 2015
    • Place of Presentation
      Vienna
    • Year and Date
      2015-03-04 – 2015-03-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dynamic Contrast-enhanced Perfusion Area Detector CT in Non-small Cell Lung Cancer Patients: Influence of Mathematical Model to Early Prediction Capabilities for Treatment Response and Recurrence after Chemoradiotherapy2014

    • Author(s)
      Yosiharu Ohno, Shinichiro Seki, Mizuho Nishio, Hisanobu Koyama, Yasuko Fujisawa,Naoki Sugihara, Takeshi Yoshikawa,Sumiaki Matsumoto, Noriyuki Negi, Tohru Murakami, Takahara Nishitani, Kazuro Sugimura
    • Organizer
      RSNA 2014
    • Place of Presentation
      Chicago
    • Year and Date
      2014-11-30 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Perfusion ADCT vs. Perfusion MRI vs. PET/CT for Pulmonary Nodule Assessment2014

    • Author(s)
      Yoshiharu Ohno, Yasuko Fujisawa, Naoki Sugihara
    • Organizer
      16th International Society of Computed Tomography
    • Place of Presentation
      San Francisco
    • Year and Date
      2014-06-09 – 2014-06-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Dynamic First-Pass Pulmonary Perfusion Area-Detector CT for Lung Nodule Assessment: Comparison of Dose Reduction Capability between Adaptive Iterative Dose Reduction using 3D Processing and Filter Back Projection2014

    • Author(s)
      Yoshiharu Ohno, Shinichiro Seki, Mizuho Nishio, Hisanobu Koyama, Takeshi Yoshikawa, Sumiaki Matsumoto, Yasuko Fujisawa, Naoki Sugihara, Kazuro Sugimura
    • Organizer
      ECR 2014
    • Place of Presentation
      Vienna
    • Related Report
      2013 Research-status Report
  • [Presentation] Area-Detector CTの最新臨床応用と今後の展望2013

    • Author(s)
      大野良治
    • Organizer
      第72回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Dynamic Perfusion ADCT vs. Dynamic Perfusion MRI vs. PET/CT: 肺結節鑑別診断能の比較2013

    • Author(s)
      大野良治,関 紳一郎,西尾瑞穂,神山久信,吉川 武,松本純明,杉村和朗
    • Organizer
      第72回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Dynamic First-Pass Perfusion ADCT for Pulmonary Nodule Assessment: Comparison with Different Mathematical Methods and FDG-PET/CT2013

    • Author(s)
      Yoshiharu Ohno
    • Organizer
      The Fleischner Society 2013 annual meeting
    • Place of Presentation
      Jeju Island
    • Related Report
      2013 Research-status Report
  • [Presentation] Pulmonary Perfusion Area-Detector CT: How to Decrease Radiation Dose and Apply in Routine Clinical Practice2013

    • Author(s)
      Yoshiharu Ohno
    • Organizer
      15th Annual Meeting of International Society of Computed Tomography
    • Place of Presentation
      Washington DC
    • Related Report
      2013 Research-status Report
  • [Presentation] Lung and Nodule Perfusion Assessments on Dynamic First-pass Perfusion Area-detector CT: Capability of Adaptive Iterative Dose Reduction Using 3D Processing (AIDR 3D) for Radiation Dose Reduction as Compared with Filter Back Projection (FBP)2013

    • Author(s)
      Yoshiharu Ohno, Mizuho Nishio, Takeshi Yoshikawa, Sumiaki Matsumoto, Yasuko Fujisawa, Naoki Sugihara, Hisanobu Koyama, Shinichiro Seki, Maho Tsubakimoto, Tohru Murakami, Masakazu Kanzawa, Kazuro Sugimura
    • Organizer
      RSNA 2013
    • Place of Presentation
      Chicago
    • Related Report
      2013 Research-status Report
  • [Presentation] Comparison of Capabilities for Differentiating Malignant SPNs from Benign SPNs among Dynamic First-Pass Perfusion Area-Detector CT, Dynamic First-Pass MRI and FDG-PET/CT2013

    • Author(s)
      Yoshiharu Ohno, Shinichiro Seki, Mizuho Nishio, Hisanobu Koyama, Takeshi Yoshikawa, Sumiaki Matsumoto, Yasuko Fujisawa, Kazuro Sugimura
    • Organizer
      ECR 2013
    • Place of Presentation
      Vienna
    • Related Report
      2012 Research-status Report
  • [Presentation] Dual-Input vs. Single-Input Perfusion CT vs. PET/CT: 肺結節鑑別診断能に関する検討2012

    • Author(s)
      大野良治,西尾瑞穂,尾西由美子,神山久信,吉川 武,竹中大祐,松本純明,藤澤恭子,杉村和朗
    • Organizer
      第71回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 胸部CTにおける被曝低減:形態診断から機能診断へ2012

    • Author(s)
      大野良治
    • Organizer
      第71回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Radiation Dose Reduction for CT Examinations: Basic Concept and New Techniques2012

    • Author(s)
      Yoshiharu Ohno
    • Organizer
      16th Workshop of the Japanese-German Radiological Affiliation
    • Place of Presentation
      Munser
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] First-Pass Perfusion Area-Detector CT: How to Analyze and Apply for Solitary Pulmonary Nodules2012

    • Author(s)
      Yoshiharu Ohno
    • Organizer
      International Society for Computed Tomography 2012
    • Place of Presentation
      San Francisco
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Dynamic First-Pass Perfusion Area-Detector CT Analyzed by Newly Developed and Previously Applied Methods vs Dynamic First-Pass MRI vs FDG-PET/CT: Differential Capability of Malignant SPN from Benign SPN2012

    • Author(s)
      Yoshiharu Ohno, Mizuho Nishio, Hisanobu Koyama, Takeshi Yoshikawa, Sumiaki Matsumoto, Yasuko Fujisawa, Naoki Sugihara, Shinichiro Seki, Masaru Yoshii, Kazuro Sugimura
    • Organizer
      RSNA 2012
    • Place of Presentation
      Chicago
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2021-12-22  

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