Evaluation of pancreatic blood-flow by non-invasive MRI technique

• Project/Area Number: 24591775
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Saga University
• Principal Investigator: IRIE Hiroyuki 佐賀大学, 医学部, 教授 (50284493)
• Co-Investigator(Kenkyū-buntansha): 野口 智幸 独立行政法人国立国際医療研究センター, その他部局等, 放射線管理室室長 (40380448)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 膵組織血流量 / MRI

Outline of Final Research Achievements

We tried to calculate pancreatic blood flow using ASL-MRI method. We evaluated several new imaging protocol for ASL-MRI. In some normal volunteer, we could calculate pancreatic blood flow by this new method, but in clinical cases, it was hard to obtain optical data. We thought that the problem was due to imaging protocol for ASL-MRI., thus, we continue to create suitable imaging protocol using water-flow phantom model. We expect to success new imaging protocol and to obtain true pancreatic blood flow in the clinical cases, such as chronic pancreatitis.

Research Products

• [Journal Article] Noninvasive method for mapping CVR in moyamoya disease using ASL-MRI. (2015)
  • Author(s): Noguchi T, Kawashima M, Nishihara M, Egashira Y, Azama S, Irie H
  • Journal Title: Eur J Radiol. Volume: xx Issue: 6 Pages: 1-7
  • DOI: 10.1016/j.ejrad.2015.03.011
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A Technical Perspective for Understanding Quantitative Arterial Spin-labeling MR Imaging using Q2TIPS (2015)
  • Author(s): Noguchi T, Nishihara M, Hara Y, Hirai T, Egashira Y, Azama S, Irie H.
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 14 Issue: 1 Pages: 1-12
  • DOI: 10.2463/mrms.2013-0064
  • NAID: 130004935523
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access
• [Journal Article] 数式とシェーマから読み解くASL-MRIの理論的背景：Q2TIPS (2013)
  • Author(s): 野口智幸、西原正志、原由紀子、平井徹良、江頭秀哲、安座間真也、入江裕之
  • Journal Title: 日本磁気共鳴医学会雑誌 Volume: 33 Pages: 147-157
  • Peer Reviewed
• [Presentation] Visual Assessment of Arterial Spin-labeling MR Imaging (ASL-MRI) for Acute Ischemic Stroke (2013)
  • Author(s): Noguchi T, Irie H, Nishihara M, Hirai T, Mizuguchi M, Hara Y
  • Organizer: 99th Scientific assembly and annual meeting of Radiological Society of North America
  • Place of Presentation: Chicago, USA
• [Presentation] Arterial Spin-Labeling MR imaging in meningoencephalitis (2013)
  • Author(s): Noguchi T, Nishihara M, Hara Y, Hirai T, Irie H
  • Organizer: 37th Annual meeting of European society of neuroradiology
  • Place of Presentation: Frankfurt (Germany)
• [Presentation] Visual Assessment of Arterial Spin-labeling MR Imaging (ASL-MRI) for Brain Tumors and Tumor-like Diseases. (2012)
  • Author(s): Noguchi T, Irie H, Nishihara M, Hirai T, Kitano I.
  • Organizer: 98th Scientific assembly and annual meeting of Radiological Society of North America
  • Place of Presentation: Chicago, IL, USA
• [Presentation] Clinical Validation Study for Averaging Factors of Arterial Spin-labeling MR Imaging. (2012)
  • Author(s): Noguchi T, Irie H, Ootsuka T, Nishihara M, Hirai T, Kitano I.
  • Organizer: 98th Scientific assembly and annual meeting of Radiological Society of North America
  • Place of Presentation: Chicago, IL, USA
• [Presentation] Arterial Spin-labeling MR Imaging (ASL-MRI) Soon After Recombinant Tissue Plasminogen Activator (r-tPA) Therapy for Patients with Hyperacute Ischemic Stroke. (2012)
  • Author(s): Nishihara M, Noguchi T, Oka T, Yakushiji Y, Ootsuka T, Irie H.
  • Organizer: 98th Scientific assembly and annual meeting of Radiological Society of North America
  • Place of Presentation: Chicago, IL, USA