| Project/Area Number |
24591777
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kumamoto University |
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Principal Investigator |
HIRAI TOSHINORI 熊本大学, 大学院生命科学研究部, 准教授 (40274724)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Manabu 熊本大学, 生命科学研究部, 教授 (60284395)
HASHIMOTO Mamoru 熊本大学, 生命科学研究部, 准教授 (20452881)
YONEDA Tetsuya 熊本大学, 生命科学研究部, 准教授 (20305022)
KOMOHARA Yoshihiro 熊本大学, 生命科学研究部, 准教授 (40449921)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | アルツハイマー病 / 神経変性疾患 / 磁気共鳴画像 / MRI / 認知症 / アミロイド / ＭＲＩ / アミロイドイメージング |
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| Outline of Final Research Achievements |
The phase images, including susceptibility-weighted imaging (SWI), may demonstrate excellent image contrast and reveal anatomical structures that are not visible on conventional MR images. A new phase-weighted MR imaging technique, termed “phase difference enhanced imaging” (PADRE), has been developed in Kumamoto University, in which the phase difference between the target and surrounding tissue was selected in order to enhance the contrast of the target tissue. Choosing the appropriate phase differences allows the variation in tissue contrast using single MR data. We applied this PADRE technique on 3-T MRI to healthy controls and AD patients. These studies demonstrated the possibility of obtaining in vivo radiologic evidence of cerebral amyloid deposition using a routinely available 3-T MRI system.
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