Response assessment of anti-angiogenetic therapy by peptide imaging agents

• Project/Area Number: 24591783
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Yokohama City University
• Principal Investigator: TATEISHI Ukihide 横浜市立大学, 医学(系)研究科(研究院), 客員教授 (20415524)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 血管新生 / 薬効判定

Outline of Final Research Achievements

Integrin specific peptide-type RGD (Arg-Gly-Asp) ligands were synthesized in order to visualize therapeutic effect of antiangiogenic agents in rat model. Integrin specific peptide-type RGD ligands was considered to be promising tool for monitering therapeutic effect of antiangiogenic agents.

Research Products

• [Journal Article] Prognostic significance of metabolic tumor burden by positron emission tomography/computed tomography in patients with relapsed/refractory diffuse large B-cell lymphoma (2015)
  • Author(s): Tateishi U, Tatsumi M, Terauchi T, Ando K, Niitsu N, Kim WS, Suh C, Ogura M, Tobinai K
  • Journal Title: Cancer Sci Volume: 106 Issue: 2 Pages: 186-193
  • DOI: 10.1111/cas.12588
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Tumor hypoxia and microscopic diffusion capacity in brain tumors: a comparison of (62)Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) PET/CT and diffusion-weighted MR imaging. (2014)
  • Author(s): Hino-Shishikura A, Tateishi U, Shibata H, Yoneyama T, Nishii T, Torii I, Tateishi K, Ohtake M, Kawahara N, Inoue T
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 41 Issue: 7 Pages: 1419-1427
  • DOI: 10.1007/s00259-014-2714-x
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 18F-Fluoride PET/CT allows detection of hyperostosis and osseous involvement in meningioma: initial experience. (2013)
  • Author(s): Tateishi U, Tateishi K, Shizukuishi K, Shishikura A, Murata H, Inoue T, Kawahara N.
  • Journal Title: Clin Nucl Med Volume: 38 Issue: 3 Pages: 125-131
  • DOI: 10.1097/rlu.0b013e318279fd79
  • Peer Reviewed
• [Journal Article] Radiolabeled RGD peptides as integrin alpha(v)beta3-targeted PET tracers (2012)
  • Author(s): Tateishi U, Oka T, Inoue T.
  • Journal Title: Curr Med Chem Volume: 19 Pages: 3301-3309
  • Peer Reviewed
• [Journal Article] Comparative study of the value of dual tracer PET/CT in evaluating breast cancer. (2012)
  • Author(s): Tateishi U, Terauchi T, Akashi-Tanaka S, et al.
  • Journal Title: Cancer Sci Volume: 103 Issue: 9 Pages: 1701-1707
  • DOI: 10.1111/j.1349-7006.2012.02348.x
  • Peer Reviewed
• [Journal Article] Neoadjuvant chemotherapy in breast cancer: prediction of pathologic response with PET/CT and dynamic contrast-enhanced MR imaging: prospective assessment (2012)
  • Author(s): Tateishi U, Miyake M, Nagaoka T, et al.
  • Journal Title: Radiology Volume: 263 Issue: 1 Pages: 53-63
  • DOI: 10.1148/radiol.12111177
  • Peer Reviewed
• [Presentation] Comparison of [Cu-62]-Diacethyl-Bis (N4-Methylthiosemicarbazone PET-CT Imaging and Microscopic Diffusion Capacity in Brain Neoplasms (2014)
  • Author(s): 鳥井郁夫、立石宇貴秀、日野彩子、井上登美夫
  • Organizer: 北米放射線学会議
  • Place of Presentation: 米国シカゴ
  • Year and Date: 2014-11-30 – 2014-12-05
• [Presentation] [Cu-62]-ATSM PET-CT as hypoxic imaging in patients with glioma (2013)
  • Author(s): Tateishi U
  • Organizer: Radiologic Society of North America
  • Place of Presentation: Chicago, USA
• [Presentation] Dual Tracer PET/CT in Patients with Breast Cancer: Direct Comparison of [C-11]Choline and [F-18]FDG for Evaluation of Tumor Delineation and Aggressiveness (2012)
  • Author(s): Tateishi U, Terauchi T, Daisaki H, Kinoshita T
  • Organizer: RSNA2012
  • Place of Presentation: 米国、シカゴ
• [Presentation] Feasibility of [Cu-62]-ATSM PET/CT as Hypoxic Imaging in Patients with Gliomas (2012)
  • Author(s): Tateishi U, Tateishi K, Shizukuishi K, Shishiura A, Yoneyama T, Inoue T
  • Organizer: RSNA2012
  • Place of Presentation: 米国、シカゴ
• [Book] 画像診断ガイドライン2013年度版 日本医学放射線学会、日本放射線科専門医会・医会編 (2013)
  • Author(s): 立石宇貴秀
  • Total Pages: 476
  • Publisher: 金原書店
• [Book] Handbook of Nuclear Medicine and Molecular Imaging (2012)
  • Author(s): E. Edmund Kim, Dong-Soo Lee, Ukihide Tateishi, Richard P. Baum
  • Total Pages: 448
  • Publisher: World Scientific
• [Patent(Industrial Property Rights)] 核医学画像データの定量化 (2013)
  • Inventor(s): 立石宇貴秀、大﨑洋充
  • Industrial Property Rights Holder: 立石宇貴秀、大﨑洋充
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-134468
  • Filing Date: 2013-06-28