Radiological-pathological correlation for depicting the invasive focus within adenocarcinomas using dual energy mode of dual source CT.

• Project/Area Number: 24591784
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Nagoya City University
• Principal Investigator: HARA Masaki 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (50244562)
• Co-Investigator(Kenkyū-buntansha): SHIBAMOTO Yuta 名古屋市立大学大学院, 医学研究科, 教授 (20144719) ; OZAWA Yoshiyuki 名古屋市立大学大学院, 医学研究科, 講師 (90569005)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: デュアルエナジーCT / デュアルソースCT / 造影CT / 肺腺癌 / part-solid nodule / すりガラス状病変 / ground glass nodule

Outline of Final Research Achievements

In this study dual energy mode of dual source computed tomography was performed in patients with primary pulmonary adenocarcinoma with lepidic growth and solid (invasive or non-invasive) component. The difference of the level of contrast enhancement among the three components was evaluated.
At first we performed the phantom studies and showed that it might be possible to do the quantitative analysis of the lepidic growth component. Then we applied this technique to the clinical cases and showed the safety and efficacy.
It was still a challenge to depict the difference between the invasive and non-invasive component of the solid lesion in the adenocarcinoma with lepidic growth appearance.

Research Products

• [Presentation] Optimal imaging parameters of contrast mapping image for the ground glass nodules using dual energy CT. (2015)
  • Author(s): Yoshiyuki Ozawa. Masaki Hara, Tatsuya Kawai., Tomohiro Suzuki. Yuta Shibamoto,
  • Organizer: 3rd. Asian Congress of Thoracic Imaging
  • Place of Presentation: Taipei
  • Year and Date: 2015-03-20 – 2015-03-22
• [Presentation] Dual energy CTを用いたGGNの造影評価． (2015)
  • Author(s): 小澤良之，河合辰哉，中川基生，小川正樹，芝本雄太，鈴木智博，原 眞咲．
  • Organizer: 日本医学放射線学会第157回中部地方会
  • Place of Presentation: 名古屋大学医学部
  • Year and Date: 2015-01-31 – 2015-02-01
• [Presentation] Definition Flash をもちいた肺野すりガラス状吸収値病変に対するcontrast mapping image指摘再構成条件 (2014)
  • Author(s): 鈴木智博，原 眞咲，小澤良之．
  • Organizer: 日本肺癌学会学術集会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2014-11-14 – 2014-11-16
• [Presentation] Difinition Flash を用いた肺野すりガラス状病変に対する Contrast mapping image 至適再構成条件 - phantom study - (2013)
  • Author(s): 鈴木智博，河合辰哉，小澤良之，芝本雄太，原 眞咲
  • Organizer: 第153回日本医学放射線学会中部地方会
  • Place of Presentation: 藤田保健衛生大学（ 豊明市）