Pathophysiological analysis of Parkinson disease using diffusion MRI

• Project/Area Number: 24591787
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Juntendo University
• Principal Investigator: CHO Narisumi 順天堂大学, 医学部, 准教授 (60236833)
• Co-Investigator(Kenkyū-buntansha): AOKI Shigeki 順天堂大学, 医学部, 教授 (80222470) ; HORI Masaaki 順天堂大学, 医学部, 准教授 (40334867)
• Research Collaborator: KAMAGATA KOJI 順天堂大学, 医学部, 助教 (60568153)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: パーキンソン病 / 拡散テンソル / 拡散尖度画像 / ＡＳＬ / 拡散テンソル像 / ASL / MRI

Outline of Final Research Achievements

Diffusion tensor imaging was used to measure significant degeneration of the white matter in the prefrontal cortex and corpus callosum in patients with Parkinson’s disease. The results showed a significant correlation between white matter degeneration and the mini mental state examination (MMSE) score, a measure of cognitive dysfunction. This suggests that quantification of white matter degeneration by diffusion tensor imaging could provide an objective biomarker for cognitive impairment in patients with Parkinson’s disease. The use of diffusion kurtosis imaging showed white matter degeneration in the anterior cingulate bundle in Parkinson’s disease patients. Diffusion kurtosis imaging was shown to be a more sensitive and specific method than diffusion tensor imaging for the diagnosis of Parkinson’s disease. The results of whole brain analysis also showed that diffusion kurtosis imaging is more sensitive than diffusion tensor imaging for detecting white matter degeneration.

Research Products

• [Journal Article] Intersite Reliability of Diffusion Tensor Imaging on Two 3T Scanners (2015)
  • Author(s): Koji Kamagata, Keigo Shimoji, Masaaki Hori, Akira Nishikori, Kohei Tsuruta, Mariko Yoshida, Kouhei Kamiya, Ryusuke Irie, Michimasa Suzuki, Shinsuke Kyogoku, Yuriko Suzuki, Noriko Sato, Shigeki Aoki.
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 14 Issue: 3 Pages: 227-233
  • DOI: 10.2463/mrms.2014-0077
  • NAID: 130005093234
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Diffusion MR Imaging of White Matter Pathways (2014)
  • Author(s): Koji Kamagata, Masaaki Hori, Kouhei Kamiya, Michimasa Suzuki, Akira Nishikori, Fumitaka Kumagai, Mariko Yoshida, Shinsuke Kyogoku, Shigeki Aoki.
  • Journal Title: Juntendo Medical Journal Volume: 60 Issue: 2 Pages: 100-106
  • DOI: 10.14789/jmj.60.100
  • NAID: 130004684324
  • ISSN: 2187-9737, 2188-2126
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A preliminary diffusional kurtosis imaging study of Parkinson disease: comparison with conventional diffusion tensor imaging. (2014)
  • Author(s): Kamagata K, Tomiyama H, Hatano T, Motoi Y, Abe O, Shimoji K, Kamiya K, Suzuki M, Hori M, Yoshida M, Hattori N, Aoki S.
  • Journal Title: Neuroradiology Volume: 56 Issue: 3 Pages: 251-258
  • DOI: 10.1007/s00234-014-1327-1
  • Peer Reviewed
• [Journal Article] Diffusional kurtosis imaging of cingulate fibers in Parkinson disease: comparison with conventional diffusion tensor imaging. (2013)
  • Author(s): Kamagata K
  • Journal Title: Magn Reson Imaging. Volume: 31(9) Issue: 9 Pages: 1501-1506
  • DOI: 10.1016/j.mri.2013.06.009
  • Peer Reviewed
• [Journal Article] Relationship between cognitive impairment and white-matter alteration in Parkinson’s disease with dementia: tract-based spatial statistics and tract-specific analysis. (2013)
  • Author(s): Kamagata K
  • Journal Title: Eur Radiol. Volume: 23(7) Issue: 7 Pages: 1946-1955
  • DOI: 10.1007/s00330-013-2775-4
  • Peer Reviewed
• [Presentation] 高分解能Neurite Orientation Dispersion and Density Imagingを用いたパーキンソン病黒質変性の評価. (2014)
  • Author(s): 鎌形康司、波田野琢、奥住文美、堀正明、阿部修、鈴木通真、錦織瞭、下地啓五、濱崎望、鈴木由里子、服部信孝、青木茂樹
  • Organizer: 第42回日本磁気共鳴医学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] パーキンソン病における嗅覚障害と脳微細構造変化の相関解析～皮質厚、灰白質容積、白質変性の評価 (2014)
  • Author(s): 鎌形康司、波田野琢、阿部修、奥住文美、堀正明、鈴木通真、下地啓五、錦織瞭、濱崎望、佐藤秀二、服部信孝、青木茂樹
  • Organizer: 第42回日本磁気共鳴医学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] R imaging of Parkinson Disease: conventional and advanced techniques. (2014)
  • Author(s): Koji Kamagata, Masaaki Hori, Kohei Kamiya, Michimasa Suzuki, Akira Nishikori, Mariko Yoshida, Fumitaka Kumagai, Taku Hatano, Hiroyuki Tomiyama, Nobutaka Hattori, Shigeki Aoki
  • Organizer: 第22回国際MR学会
  • Place of Presentation: ミラノ
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] Preliminary Diffusional Kurtosis Imaging of the substantia nigra in de novo Parkinson disease: Diagnostic Utility of Histogram Analysis. (2014)
  • Author(s): Koji Kamagata, Masaaki Hori, Kohei Kamiya, Michimasa Suzuki, Akira Nishikori, Mariko Yoshida, Fumitaka Kumagai, Taku Hatano, Hiroyuki Tomiyama, Nobutaka Hattori, Shigeki Aoki
  • Organizer: 第22回国際MR学会
  • Place of Presentation: ミラノ
  • Year and Date: 2014-05-10 – 2014-05-15
• [Presentation] Diffusional Kurtosis Imagingを用いたパーキンソン病における黒質定量：ヒストグラム解析の診断的有用性. (2014)
  • Author(s): 鎌形康司、富山弘幸、本井ゆみ子、阿部修、下地啓五、鈴木通真、堀正明、服部信孝、青木茂樹.
  • Organizer: 第43回日本神経放射線学会
  • Place of Presentation: 米子
• [Presentation] Diffusional Kurtosis Imagingを用いたパーキンソン病患者の予備的検討；Diffusion Tensor Imagingとの比較 (2013)
  • Author(s): 鎌形 康司、富山 弘幸、本井 ゆみ子、阿部修、伊藤賢治、下地啓五、鈴木通真、堀正明、中西淳、桑鶴良平、笹井啓資、青木茂樹、服部信孝
  • Organizer: 第41回日本磁気共鳴医学会大会
  • Place of Presentation: 徳島
• [Presentation] パーキンソン病のMRI〜古典的所見とadvanced techniqueによるmultimodal MRI (2013)
  • Author(s): 鎌形 康司
  • Organizer: 第41回日本磁気共鳴医学会大会
  • Place of Presentation: 徳島
  • Invited
• [Presentation] パーキンソン病のMRI；MRIによる古典的所見とcutting edge technique (2013)
  • Author(s): 鎌形 康司、富山 弘幸、本井 ゆみ子、下地啓五、鈴木通真、堀正明、中西淳、桑鶴良平、服部信孝、青木茂樹
  • Organizer: 第72回日本医学放射線学会総会
  • Place of Presentation: 横浜
• [Presentation] MR imaging of Parkinson Disease: conventional and advanced techniques
  • Author(s): 鎌形 康司、堀 正明、青木 茂樹
  • Organizer: 第20回国際磁気共鳴医学会大会
  • Place of Presentation: メルボルン
• [Presentation] パーキンソン病における白質障害と認知機能との関連～TBSSを用いた検討
  • Author(s): 鎌形 康司、堀 正明、青木 茂樹
  • Organizer: 第35回神経科学会
  • Place of Presentation: 名古屋
• [Presentation] 高磁場MRIを用いたパーキンソン病の大脳白質微細構造及び脳血流の評価
  • Author(s): 鎌形 康司、堀 正明、青木 茂樹
  • Organizer: 第14回ヒト脳機能マッピング学会
  • Place of Presentation: 札幌
• [Presentation] 拡散テンソル及びDiffusional kurtosis imagingによるパーキンソン病患者の帯状束白質障害
  • Author(s): 鎌形 康司、堀 正明、青木 茂樹
  • Organizer: 第40回日本磁気共鳴医学会大会
  • Place of Presentation: 京都
• [Presentation] Diffusional Kurtosis Imagingを用いたパーキンソン病における大脳皮質変性の定量解析；Lewy小体病理との関連
  • Author(s): 鎌形 康司、堀 正明、青木 茂樹
  • Organizer: 第42回神経放射線学会
  • Place of Presentation: 小倉