| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We compared diagnostic accuracy of N-13 ammonia PET/CT (PET) and contrast-enhanced CT for evaluation of adenosine-induced myocardial hypo-perfusion in 11 patients with coronary arterial disease who had been documented myocardial ischemia on SPECT. Severity of myocardial ischemia was graded into 5 categories on PET. Myocardial ischemia was judged as positive on CTP when TPR (transmural perfusion ratio) was less than 1.0. From vessel-based analysis for 33 coronary territories, sensitivity and specificity of CTP for detecting any PET positive territories were 0.88 and 0.81, respectively. From segment-based analysis for 176 myocardial segments, sensitivity and specificity of CTP for detecting PET positive segments with equal or greater than grade 1 were 0.59 and 0.87, equal or greater than grade 2 0.73 and 0.82, and equal or greater than grade 3 0.90 and 0.75, respectively. In conclusion, CTP has limitation in detecting mild myocardial ischemia documented on N-13 ammonia PET/CT.
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