| Project/Area Number |
24591790
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tokyo Women's Medical University (2014-2015)
Toho University (2012-2013) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Terada Hitoshi 東邦大学, 医学部, 教授 (90227520)
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| Co-Investigator(Renkei-kenkyūsha) |
Aoki Ichio 国立研究開発法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (10319519)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | MRスペクトルスコピー / 核磁気共鳴画像（MRI） / 先天性大脳白質形成不全症 / Pelizaeus-Merzbacher 病 / N-acetylaspartate (NAA) / choline (Cho) / モデルマウス / Pelizaeus-Merzbacher病 / Choline / マウスモデル / 副腎白質ジストロフィー / 18q-症候群 / 大脳白質形成不全症 / 磁気共鳴画像 / ＭＲスペクトルスコピー / 脳代謝 / 髄鞘形成不全 |
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| Outline of Final Research Achievements |
Proton MR spectroscopy (MRS) of a hypomyelinating mouse model, a myelin synthesis-deficient mouse, a model of connatal Pelizaeus-Merzbacher disease (PMD) with mutation of the Plp1 gene, revealed increased N-acetylaspartate (NAA) and creatine (Cr) and decreased choline (Cho). That of a shiverer mouse with an autosomal recessive mutation of the Mbp gene showed decreased Cho with normal NAA and Cr. Accordingly, the reduction of Cho on MRS might be a common marker for hypomyelinating disorders. NAA concentrations range from normal to increased, probably depending upon the underlying pathology of oligodendrocytes. NAA may be increased in hypomyelination with a reduced number of mature oligodendrocytes, such as PMD.
The MRS pattern with reduced Cho and normal to increased NAA may lead to a diagnosis of hypomyelinating disorders, which is difficult to differentiate from demyelinating disorders on MR imaging.
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