Molecular imaging of Kawasaki vasculitis

• Project/Area Number: 24591798
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kurume University
• Principal Investigator: SUDA KENJI 久留米大学, 医学部, 准教授 (10399173)
• Co-Investigator(Kenkyū-buntansha): TAHARA Nobuhiro 久留米大学, 医学部, 准教授 (10320186) ; KUDO Yoshiyuki 久留米大学, 医学部, 助教 (10368920) ; YOSHIMOTO Hironaga 久留米大学, 医学部, 助教 (10624463) ; ISHIBASHI Masatoshi 久留米大学, 医学部, 教授 (20168256) ; IEMURA Motofumi 久留米大学, 医学部, 助教 (30399175)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ポジトロンエミッショントモグラフィー / 川崎病 / 冠動脈瘤 / 冠状動脈瘤 / 分子イメージング / FDG-PET

Outline of Final Research Achievements

More than 14,000 Japanese children are suffered from Kawasaki diesase, a most prevalent vasculitis in developed countries and about 1% of them left with coronary aneurysms as sequelae. Though coronary aneurysms show remodeling with intimal thickenning, leading to ischemic heart disease, the mechanisms of this remodeing is unknown. In this study with positron emission tomography using 18 fluorodeoxyglucose, we have demonstrated that indeed local inflammation of coronary artery aneurysms persist long after Kawasaki disease.

Research Products

• [Journal Article] Statin reduces persistent coronary arterial inflammation evaluated by serial 18fluorodeoxyglucose positron emission tomography imaging long after Kawasaki disease. (2015)
  • Author(s): Suda K, Tahara N, Honda A, Yoshimoto H, Kishimoto S, Kudo Y, Kaida H, Abe T, Ueno T, Fukumoto Y.
  • Journal Title: Int J Cardiol Volume: 179 Pages: 61-62
  • DOI: 10.1016/j.ijcard.2014.10.057
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Persistent peripheral arteritis long after Kawasaki disease - another documentation of ongoing vascular inflammation. (2015)
  • Author(s): Suda K, Tahara N, Honda A, Iemura M, Yoshimoto H, Kudo Y, Kaida H, Abe T, Sawada K, Akashi H, Tanaka H, Fukumoto Y.
  • Journal Title: Int J Cardiol Volume: 180 Pages: 88-90
  • DOI: 10.1016/j.ijcard.2014.11.205
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Persistent coronary arterial inflammation in a patient long after the onset of Kawasaki disease. (2012)
  • Author(s): Suda K, Tahara N, Kudo Y, Yoshimoto H, Iemura M, Ueno T, Kaida H, Ishinashi M, Imaizumi T.
  • Journal Title: Int J Cardiol Volume: 154 Pages: 193-194
  • Peer Reviewed
• [Presentation] Statin Alleviates Persistent Coronary Arterial Inflammation Long After Kawasaki Disease - A Serial Fluorodeoxyglucose Positron Emission Tomography Study. (2015)
  • Author(s): Suda K, Tahara N, Honda A, Yoshimoto H, Kishimoto S, Kudo Y, Kaida H, Abe T, Ueno T, Fukumoto Y.
  • Organizer: 11th International Kawasaki Disease Symposium.
  • Place of Presentation: Hilton Hawaiian Village, Honolulu, USA
  • Year and Date: 2015-02-03 – 2015-02-06
• [Presentation] Persistent Peripheral Arteritis Long After Kawasaki Disease - Another Documentation Of Ongoing Vascular Inflammation. (2015)
  • Author(s): Suda K, Tahara N, Honda A, Imemura M, Yoshimoto H, Kishimoto S, Kudo Y, Tanaka H, Kaida H, Abe T, Ueno T, Fukumoto Y.
  • Organizer: 11th International Kawasaki Disease Symposium
  • Place of Presentation: Hawaiian Village, Honolulu, USA
  • Year and Date: 2015-02-03 – 2015-02-06
• [Presentation] 川崎病冠後遺症の自然歴－巨大冠動脈瘤の予後－．合同セッション 川崎病後冠動脈障害と成人期冠イベント：症例検討と成人期川崎病情報 update． (2012)
  • Author(s): 須田憲治
  • Organizer: 第21回日本心血管インターベンション治療学会(CVIT2012)
  • Place of Presentation: 新潟
• [Presentation] 川崎病既往成人における急性冠症候群：これからの診療体制の構築に向けて．③川崎病冠動脈障害の長期展望～成人期冠イベントの危険因子として～ (2012)
  • Author(s): 三谷義英，津田悦子，賀藤 均，小川俊一，中村好一，高橋 啓，藤原優子，鮎沢 衛，小林 徹，市田蕗子，松島正気，鎌田政博，檜垣高史，須田憲治，横井宏佳，濱岡建城．
  • Organizer: 第48回日本小児循環器学会
  • Place of Presentation: 京都
• [Presentation] 川崎病後遠隔期末梢動脈病変に18F-FDGの集積を認めた2例． (2012)
  • Author(s): 家村素史，田原宣広，高瀬隆太，吉本裕良，工藤嘉公，須田憲治，上野高史，松石豊次郎．
  • Organizer: 第32回日本川崎病学会
  • Place of Presentation: 東京
• [Presentation] Determinant of increased type B natriuretic peptide (BNP) in acute phase of Kawasaki disease. (2012)
  • Author(s): Suda K, Kishimoto S, Kudo Y, Nishino H, Takahashi T, Okamura H, Teramachi Y, Yoshimoto H, Iemura M, Matsuishi T.
  • Organizer: 6th Annual Meeting of the Association for European Pediatric and Congenital Carddiology
  • Place of Presentation: Istanbul
• [Presentation] 川崎病冠動脈炎の分子イメージング． (2012)
  • Author(s): 須田憲治，工藤嘉公，吉本裕良，家村素史，松石豊次郎
  • Organizer: 第32回日本川崎病学会
  • Place of Presentation: 東京
• [Book] Wiley-Blackwell Publishing Ltd (2012)
  • Author(s): Kato H, Suda K
  • Publisher: Ch 63. Kawasaki disease in Pediatric Cardiovascular Medicine, 2nd ed.