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Molecular imaging of Kawasaki vasculitis

Research Project

Project/Area Number 24591798
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKurume University

Principal Investigator

SUDA KENJI  久留米大学, 医学部, 准教授 (10399173)

Co-Investigator(Kenkyū-buntansha) TAHARA Nobuhiro  久留米大学, 医学部, 准教授 (10320186)
KUDO Yoshiyuki  久留米大学, 医学部, 助教 (10368920)
YOSHIMOTO Hironaga  久留米大学, 医学部, 助教 (10624463)
ISHIBASHI Masatoshi  久留米大学, 医学部, 教授 (20168256)
IEMURA Motofumi  久留米大学, 医学部, 助教 (30399175)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsポジトロンエミッショントモグラフィー / 川崎病 / 冠動脈瘤 / 冠状動脈瘤 / 分子イメージング / FDG-PET
Outline of Final Research Achievements

More than 14,000 Japanese children are suffered from Kawasaki diesase, a most prevalent vasculitis in developed countries and about 1% of them left with coronary aneurysms as sequelae. Though coronary aneurysms show remodeling with intimal thickenning, leading to ischemic heart disease, the mechanisms of this remodeing is unknown. In this study with positron emission tomography using 18 fluorodeoxyglucose, we have demonstrated that indeed local inflammation of coronary artery aneurysms persist long after Kawasaki disease.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (11 results)

All 2015 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (7 results) Book (1 results)

  • [Journal Article] Statin reduces persistent coronary arterial inflammation evaluated by serial 18fluorodeoxyglucose positron emission tomography imaging long after Kawasaki disease.2015

    • Author(s)
      Suda K, Tahara N, Honda A, Yoshimoto H, Kishimoto S, Kudo Y, Kaida H, Abe T, Ueno T, Fukumoto Y.
    • Journal Title

      Int J Cardiol

      Volume: 179 Pages: 61-62

    • DOI

      10.1016/j.ijcard.2014.10.057

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Persistent peripheral arteritis long after Kawasaki disease - another documentation of ongoing vascular inflammation.2015

    • Author(s)
      Suda K, Tahara N, Honda A, Iemura M, Yoshimoto H, Kudo Y, Kaida H, Abe T, Sawada K, Akashi H, Tanaka H, Fukumoto Y.
    • Journal Title

      Int J Cardiol

      Volume: 180 Pages: 88-90

    • DOI

      10.1016/j.ijcard.2014.11.205

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Persistent coronary arterial inflammation in a patient long after the onset of Kawasaki disease.2012

    • Author(s)
      Suda K, Tahara N, Kudo Y, Yoshimoto H, Iemura M, Ueno T, Kaida H, Ishinashi M, Imaizumi T.
    • Journal Title

      Int J Cardiol

      Volume: 154 Pages: 193-194

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Statin Alleviates Persistent Coronary Arterial Inflammation Long After Kawasaki Disease - A Serial Fluorodeoxyglucose Positron Emission Tomography Study.2015

    • Author(s)
      Suda K, Tahara N, Honda A, Yoshimoto H, Kishimoto S, Kudo Y, Kaida H, Abe T, Ueno T, Fukumoto Y.
    • Organizer
      11th International Kawasaki Disease Symposium.
    • Place of Presentation
      Hilton Hawaiian Village, Honolulu, USA
    • Year and Date
      2015-02-03 – 2015-02-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Persistent Peripheral Arteritis Long After Kawasaki Disease - Another Documentation Of Ongoing Vascular Inflammation.2015

    • Author(s)
      Suda K, Tahara N, Honda A, Imemura M, Yoshimoto H, Kishimoto S, Kudo Y, Tanaka H, Kaida H, Abe T, Ueno T, Fukumoto Y.
    • Organizer
      11th International Kawasaki Disease Symposium
    • Place of Presentation
      Hawaiian Village, Honolulu, USA
    • Year and Date
      2015-02-03 – 2015-02-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 川崎病冠後遺症の自然歴-巨大冠動脈瘤の予後-.合同セッション 川崎病後冠動脈障害と成人期冠イベント:症例検討と成人期川崎病情報 update.2012

    • Author(s)
      須田憲治
    • Organizer
      第21回日本心血管インターベンション治療学会(CVIT2012)
    • Place of Presentation
      新潟
    • Related Report
      2012 Research-status Report
  • [Presentation] 川崎病既往成人における急性冠症候群:これからの診療体制の構築に向けて.③川崎病冠動脈障害の長期展望~成人期冠イベントの危険因子として~2012

    • Author(s)
      三谷義英,津田悦子,賀藤 均,小川俊一,中村好一,高橋 啓,藤原優子,鮎沢 衛,小林 徹,市田蕗子,松島正気,鎌田政博,檜垣高史,須田憲治,横井宏佳,濱岡建城.
    • Organizer
      第48回日本小児循環器学会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] 川崎病後遠隔期末梢動脈病変に18F-FDGの集積を認めた2例.2012

    • Author(s)
      家村素史,田原宣広,高瀬隆太,吉本裕良,工藤嘉公,須田憲治,上野高史,松石豊次郎.
    • Organizer
      第32回日本川崎病学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Determinant of increased type B natriuretic peptide (BNP) in acute phase of Kawasaki disease.2012

    • Author(s)
      Suda K, Kishimoto S, Kudo Y, Nishino H, Takahashi T, Okamura H, Teramachi Y, Yoshimoto H, Iemura M, Matsuishi T.
    • Organizer
      6th Annual Meeting of the Association for European Pediatric and Congenital Carddiology
    • Place of Presentation
      Istanbul
    • Related Report
      2012 Research-status Report
  • [Presentation] 川崎病冠動脈炎の分子イメージング.2012

    • Author(s)
      須田憲治,工藤嘉公,吉本裕良,家村素史,松石豊次郎
    • Organizer
      第32回日本川崎病学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Book] Wiley-Blackwell Publishing Ltd2012

    • Author(s)
      Kato H, Suda K
    • Publisher
      Ch 63. Kawasaki disease in Pediatric Cardiovascular Medicine, 2nd ed.
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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