Development of functional neural circuit imaging
| Project/Area Number |
24591800
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Okinawa Institute of Science and Technology Graduate University (2014-2015)
Central Institute for Experimental Animals (2012-2013) |
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Principal Investigator |
Hikishima Keigo 沖縄科学技術大学院大学, その他部局等, その他 (30420219)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | MRI / 黒質線条体経路 |
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| Outline of Final Research Achievements |
We developed an analysis to visualize nigrostriatal pathway using magnetic resonance imaging (MRI) and succeeded in the evaluation of the nigrostriatal degeneration in the common marmoset model of the Parkinson’s disease. This method could be a powerful translational diagnostic tool for the monitoring disease process and the evaluating efficacy of new treatment of Parkinson’s disease.
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Report
(5 results)
Research Products
(20 results)
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[Journal Article] Voxel-based morphometry of the marmoset brain: In vivo detection of volume loss in the substantia nigra of the MPTP-treated Parkinson's disease model.2015
Author(s)
Hikishima K, Ando K, Komaki Y, Kawai K, Yano R, Inoue T, Itoh T, Yamada M, Momoshima S, Okano HJ, Okano H
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Journal Title
Neuroscience
Volume: 300
Pages: 585-592
Related Report
Peer Reviewed
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[Journal Article] Parkinson Disease: Diffusion MR Imaging to Detect Nigrostriatal Pathway Loss in a Marmoset Model Treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.2015
Author(s)
Hikishima K, Ando K, Yano R, Kawai K, Komaki Y, Inoue T, Itoh T, Yamada M, Momoshima S, Okano HJ, Okano H.
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Journal Title
Radiology
Volume: 275(2)
Issue: 2
Pages: 430-7
DOI
Related Report
Peer Reviewed
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[Journal Article] Atlas of the developing brain of the marmoset monkey constructed using magnetic resonance histology.2013
Author(s)
Hikishima K, Sawada K, Murayama AY, Komaki Y, Kawai K, Sato N, Inoue T, Itoh T, Momoshima S, Iriki A, Okano HJ, Sasaki E, Okano H
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Journal Title
Neuroscience
Volume: 230
Pages: 102-113
DOI
Related Report
Peer Reviewed
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[Presentation] A high-resolution MRI study of developing brain in common marmosets.2012
Author(s)
Hikishima K, Sawada K, Murayama AY, Komaki Y, Kawai K, Sato N, Inoue T, Itoh T, Momoshima S, Okano HJ, Sasaki E, Okano H
Organizer
APRU-BMAP2012
Place of Presentation
Tokyo
Related Report
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[Presentation] Time-course and high-resolution MRI in developing primate brain of common marmoset.2012
Author(s)
Hikishima K, Sawada K, Komaki Y, Murayama AY, Kawai K, Sato N, Inoue T, Itoh T, Momoshima S, Okano HJ, Sasaki E, Okano H
Organizer
20th annual meeting of ISMRM
Place of Presentation
Australia
Related Report
