Development of functional neural circuit imaging

• Project/Area Number: 24591800
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Okinawa Institute of Science and Technology Graduate University (2014-2015); Central Institute for Experimental Animals (2012-2013)
• Principal Investigator: Hikishima Keigo 沖縄科学技術大学院大学, その他部局等, その他 (30420219)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: MRI / 黒質線条体経路

Outline of Final Research Achievements

We developed an analysis to visualize nigrostriatal pathway using magnetic resonance imaging (MRI) and succeeded in the evaluation of the nigrostriatal degeneration in the common marmoset model of the Parkinson’s disease. This method could be a powerful translational diagnostic tool for the monitoring disease process and the evaluating efficacy of new treatment of Parkinson’s disease.

Research Products

• [Journal Article] Voxel-based morphometry of the marmoset brain: In vivo detection of volume loss in the substantia nigra of the MPTP-treated Parkinson's disease model. (2015)
  • Author(s): Hikishima K, Ando K, Komaki Y, Kawai K, Yano R, Inoue T, Itoh T, Yamada M, Momoshima S, Okano HJ, Okano H
  • Journal Title: Neuroscience Volume: 300 Pages: 585-592
  • Peer Reviewed
• [Journal Article] Parkinson Disease: Diffusion MR Imaging to Detect Nigrostriatal Pathway Loss in a Marmoset Model Treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine. (2015)
  • Author(s): Hikishima K, Ando K, Yano R, Kawai K, Komaki Y, Inoue T, Itoh T, Yamada M, Momoshima S, Okano HJ, Okano H.
  • Journal Title: Radiology Volume: 275(2) Issue: 2 Pages: 430-7
  • DOI: 10.1148/radiol.14140601
  • Peer Reviewed
• [Journal Article] Atlas of the developing brain of the marmoset monkey constructed using magnetic resonance histology. (2013)
  • Author(s): Hikishima K, Sawada K, Murayama AY, Komaki Y, Kawai K, Sato N, Inoue T, Itoh T, Momoshima S, Iriki A, Okano HJ, Sasaki E, Okano H
  • Journal Title: Neuroscience Volume: 230 Pages: 102-113
  • DOI: 10.1016/j.neuroscience.2012.09.053
  • Peer Reviewed
• [Journal Article] プレクリニカルMRIを理解する (2012)
  • Author(s): 疋島啓吾、山田雅之、藤吉兼浩、小牧裕司、百島祐貴、中村雅也、岡野栄之
  • Journal Title: 日本放射線技師会誌 Volume: 59 Pages: 622-626
• [Presentation] MRIによる神経連絡の解析 (2015)
  • Author(s): 疋島啓吾
  • Organizer: 第6回光操作研究会
  • Place of Presentation: 仙台
  • Year and Date: 2015-08-21 – 2015-08-22
  • Invited
• [Presentation] Dopaminergic Neurodegeneration in Nigrostriatal System of the MPTP-treated Parkinsonian Marmoset Monkey Detected by Voxel-based Analysis of Longitudinal MRI. (2013)
  • Author(s): Keigo Hikishima
  • Organizer: RSNA2013
  • Place of Presentation: Chicago
• [Presentation] モデル動物のMRニューロイメージング (2013)
  • Author(s): 疋島啓吾
  • Organizer: 包括脳ネットワーク夏のワークショップ
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] MRI of neurological disease models in the non-human primate. (2013)
  • Author(s): 疋島啓吾
  • Organizer: 2nd International Joint Symposium “Ultra High Field-MRI”
  • Place of Presentation: 東京
  • Invited
• [Presentation] マーモセットのMR神経画像解析 (2013)
  • Author(s): 疋島啓吾
  • Organizer: 第3回 日本マーモセット研究会大会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] 再生医療研究を支援する画像解析システム (2013)
  • Author(s): 疋島啓吾
  • Organizer: 第６回In vivo実験医学シンポジウム
  • Place of Presentation: 東京
  • Invited
• [Presentation] マーモセットのMRI神経画像解析 (2013)
  • Author(s): 疋島啓吾
  • Organizer: 第2回 日本マーモセット研究会大会
  • Place of Presentation: 東京
  • Invited
• [Presentation] げっ歯類、小型霊長類のＭＲニューロイメージング (2013)
  • Author(s): 疋島啓吾
  • Organizer: 第 244 回生理学東京談話会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 小型霊長類マーモセットにおける大脳皮質層構造、神経連絡の発達 ～拡散MRIを用いた神経微細構造解析～ (2013)
  • Author(s): 疋島啓吾、澤田和彦、村山綾子、佐々木えりか、岡野 栄之
  • Organizer: 第118回日本解剖学会 全国学術大会
  • Place of Presentation: 高松
  • Invited
• [Presentation] Neuroimaging research for marmoset monkey. (2012)
  • Author(s): Keigo Hikishima
  • Organizer: NTU-CHC Human Cognition Workshop
  • Place of Presentation: Singapore
  • Invited
• [Presentation] マーモセットの高磁場MRI (2012)
  • Author(s): 疋島啓吾
  • Organizer: 包括脳MRI脳画像チュートリアル
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] 拡散MRI～q-space imaging による髄鞘の可視化～ (2012)
  • Author(s): 疋島啓吾
  • Organizer: 第二回信濃町Neuro Imaging Conference
  • Place of Presentation: 東京
  • Invited
• [Presentation] 高分解能MRIによるマーモセット発達脳の画像解析 (2012)
  • Author(s): 疋島啓吾、澤田和彦、村山綾子、小牧裕司、川井健司、佐藤菜名子、井上貴史、伊藤豊志雄、百島祐貴、岡野ジェイムス洋尚、佐々木えりか、岡野栄之
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] A high-resolution MRI study of developing brain in common marmosets. (2012)
  • Author(s): Hikishima K, Sawada K, Murayama AY, Komaki Y, Kawai K, Sato N, Inoue T, Itoh T, Momoshima S, Okano HJ, Sasaki E, Okano H
  • Organizer: APRU-BMAP2012
  • Place of Presentation: Tokyo
• [Presentation] 4D MRI atlas for developing brain of common marmoset (2012)
  • Author(s): 疋島啓吾
  • Organizer: 第44回慶應ニューロサイエンス研究会
  • Place of Presentation: 東京
• [Presentation] Time-course and high-resolution MRI in developing primate brain of common marmoset. (2012)
  • Author(s): Hikishima K, Sawada K, Komaki Y, Murayama AY, Kawai K, Sato N, Inoue T, Itoh T, Momoshima S, Okano HJ, Sasaki E, Okano H
  • Organizer: 20th annual meeting of ISMRM
  • Place of Presentation: Australia